What's Going on beyond the Corner in the Treatment of Sepsis?

Dear Colleagues,

Since the end of the last century, intensivists have relied on guidelines periodically issued and updated by the Surviving Sepsis Campaign to treat critically ill sepsis patients. These guidelines are prepared based on the results of randomized controlled trials performed in the preceding years that involved thousands of patients, and each recommendation is graded according to the robustness of the gathered data. Therefore, the guidelines are already at risk of obsolescence when they are issued. As many innovative investigations in the field of sepsis are currently under way, we find it useful to present and discuss possible future developments in the field of sepsis.

Possible future issues in this field are as follows:

1. New diagnostic methods for the identification of the responsible organisms, extending from the laboratory to the bedside;
2. New antibacterial strategies;
3. Old and new markers of sepsis: diagnosis before symptoms;
4. The manipulation of the microbiome;
5. The immunomodulation approach used to treat sepsis patients, extending from immunosuppression to immunostimulation;
6. The new blood purification techniques: is prevention better than cure?;
7. When sepsis is not sepsis: hyperinflammatory syndromes associated with biological agents.

Prof. Dr. Giorgio Berlot
Guest Editor

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• septic shock
• immumomodulation
• blood purification
• sepsis markers
• multiple organ failure
• infections