Cardiac Fibrosis and Remodeling

Dear Colleagues,

Cardiac fibrosis is an underlying pathology in many forms of heart disease and is known to result from an imbalance in the synthesis and degradation of the myocardial extracellular matrix (ECM) and tissue remodeling. Chronic myocardial fibrosis is a poor prognostic sign that is known to cause diastolic and systolic dysfunction and increase susceptibility of the heart to arrhythmias leading to heart failure. Several studies have underscored the importance of cardiac fibroblasts in ECM synthesis and remodeling during normal heart development and disease states. There is a growing body of knowledge on topics including but not limited to lineage tracing of cardiac fibroblasts, phenotype conversion of fibroblasts into myofibroblasts, mediators and signal transduction pathways regulating fibrosis, the role of microRNAs and pharmacological agents in fibrosis, and tissue remodeling. The Special Issue of cardiac fibrosis and remodeling aims to shed light on new models of myocardial fibrosis, emerging fibrosis pathways, biomarkers, detection methodologies, the role of immune system and metabolic pathways, and genetic and pharmacological interventions as well as limitations and challenges for the translation of mechanistic knowledge into the clinic.

Prof. Dr. Kishore Pasumarthi
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-anonymized peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Cardiovascular Development and Disease is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.