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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic. The journal’s Editor-in-Chief and/or designated EBM will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Research Advances in Whole-Genome/Exome Sequencing (WGS/WES) and Next-Generation Sequencing
edited by
submission deadline 30 May 2024 | Viewed by 201 | Submission Open
Keywords: short/long-read sequencing; whole-exome sequencing; whole-genome sequencing; bioinformatics; variant classification models; translational medicine
(This special issue belongs to the Section Molecular Genetics and Genomics)
The Dynamics of Redox Metabolism in Plants submission deadline 30 May 2024 | Viewed by 200 | Submission Open
Keywords: plant metabolism; plant stress; post-translational modifications; reactive oxygen/nitrogen/sulfur species; redox regulation; signaling
(This special issue belongs to the Section Molecular Plant Sciences)
Molecular Advances in Blood–Brain Barrier, Blood–Cerebrospinal Fluid Barrier and Cerebrospinal Fluid–Brain Barriers submission deadline 30 May 2024 | Viewed by 199 | Submission Open
Keywords: blood– brain barrier (BBB); blood– cerebrospinal fluid (CSF) barrier (BCSFB); CSF– brain barriers (CSFBB); brain homeostasis; neuroscience; depression; multiple sclerosis; stroke
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Natural-Derived Nanocarriers as Delivery Systems for Biomolecules
edited by
submission deadline 30 May 2024 | Viewed by 186 | Submission Open
Keywords: natural nanocarriers; biomolecules; delivery systems; nanomedicine; human health; controlled release
(This special issue belongs to the Section Molecular Biology)
Model Organisms in Plant Science: Metal Transport in Tomato
edited by
submission deadline 30 May 2024 | Viewed by 184 | Submission Open
Keywords: metal; uptake; translocation; sequestration; transmembrane transport
(This special issue belongs to the Section Molecular Plant Sciences)
Molecular Computational Modelling in the Context of Safe and Sustainability-by-Design Strategy
edited by Alicja Mikołajczyk
submission deadline 30 May 2024 | Viewed by 178 | Submission Open
Keywords: molecular informatics; molecular computational modelling; materials modeling; molecular study; chemoinformatic design
(This special issue belongs to the Section Molecular Informatics)
Bioactive Materials with Antimicrobial Properties 2.0 submission deadline 30 May 2024 | Viewed by 168 | Submission Open
Keywords: bioactivity; biomedical application; smart packaging; aerospace; textile; antimicrobic activity; antifungal activity
(This special issue belongs to the Section Molecular Microbiology)
New Molecular Insights into Antimicrobial Photo-Treatments
edited by Pietro Delcanale
submission deadline 30 May 2024 | Viewed by 168 | Submission Open
Keywords: photodynamic inactivation; photo-thermal therapy; photosensitization; antimicrobials; reactive oxygen species; photo-treatments; antibiotic resistance; singlet oxygen; antivirals
(This special issue belongs to the Section Molecular Microbiology)
Advances in Molecular Research of Diabetic Cardiomyopathy submission deadline 30 May 2024 | Viewed by 165 | Submission Open
Keywords: diabetic cardiomyopathy; apoptosis; diabetes; myocardial fibrosis; stem cells; inflammation; therapeutic approaches
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Editorial Board Members’ Collection Series: Chemical Molecular Structure, Function and Reactions submission deadline 30 May 2024 | Viewed by 164 | Submission Open
Keywords: chemical molecules; chemical reactions; molecules interations; molecules structure; molecular dynamics
(This special issue belongs to the Section Physical Chemistry and Chemical Physics)
Circadian Biology in Human Health and Disease
edited by Flore Sinturel
submission deadline 30 May 2024 | Viewed by 161 | Submission Open
Keywords: circadian rhythms; metabolism; misalignment; synchronization; molecular clock; internal body clocks; sleep– wake cycle
(This special issue belongs to the Section Molecular Biology)
Advances in the Research of Alzheimer’s Disease and Dietary Neuroprotective Agents submission deadline 30 May 2024 | Viewed by 161 | Submission Open
Keywords: neurodegenerative disorders; brain health; brain– gut-microbiome axis; blood– brain barrier assays; anti-inflammatory activity; antichlolinergic activity; antioxidant activity; bioactive phytochemicals; mechanisms of neuroprotection; brain foods; neuroprotection
(This special issue belongs to the Section Molecular Neurobiology)
The Powerhouse: Mitochondria in Health and Disease
edited by
submission deadline 30 May 2024 | Viewed by 160 | Submission Open
Keywords: mitochondria; targeted therapies; metabolism; ROS; bioenergetics; disease
(This special issue belongs to the Section Molecular Biology)
Molecular Mechanism and Treatment of Allergic Asthma
edited by and Marcello Cottini
submission deadline 30 May 2024 | Viewed by 155 | Submission Open
Keywords: allergic asthma; epithelial barrier damage; protease allergen; type 2 inflammation
(This special issue belongs to the Section Molecular Immunology)
Mechanistic Studies of Mitosis
edited by Eleni Petsalaki
submission deadline 30 May 2024 | Viewed by 144 | Submission Open
Keywords: mitosis; cancer; cell biology; spindle checkpoint; abscission; abscission checkpoint; cytokinesis
(This special issue belongs to the Section Biochemistry)
Advanced Research on Obesity and Cancer
edited by
submission deadline 30 May 2024 | Viewed by 141 | Submission Open
Keywords: obesity; body fat; cancer; adipokines; leptin; adiponectin; angiogenesis; molecular activity; signaling pathways
(This special issue belongs to the Section Molecular Oncology)
Molecular Mechanisms and Therapeutic Advances in Brain Metastasis
edited by Malcolm Lim
submission deadline 30 May 2024 | Viewed by 139 | Submission Open
Keywords: brain metastasis; brain microenvironment; neurotransmitters co-option; blood-tumour barrier; cancer drug delivery; targeted radiotherapy
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Drug Resistance Mechanisms in Human Cancer Cells to Anticancer Drugs
edited by
submission deadline 30 May 2024 | Viewed by 134 | Submission Open
Keywords: cancer therapy; targeted therapy; combination therapy; drug resistance; resensitization; DNA repair; DNA damage response; DNA repair inhibitors; synthetic lethality; chemoradiation
(This special issue belongs to the Section Molecular Pharmacology)
Molecular Mechanisms of Primary Graft Dysfunction and Acute Rejection in Solid Organ Transplantation
edited by
submission deadline 30 May 2024 | Viewed by 128 | Submission Open
Keywords: transplant; graft dysfunction; ischemia– reperfusion injury; DAMPs; immune cells; allo-antigens; acute rejection; metabolism; cell death; MHC; PRRs
(This special issue belongs to the Section Molecular Immunology)
Anti-hypoxia and Oxygenation Agents for Cancer Immunotherapy
edited by Stephen M. Hatfield and Bruce D. Spiess
submission deadline 30 May 2024 | Viewed by 127 | Submission Open
Keywords: oxygenation agents; blood substitutes; immune checkpoint inhibitors; cancer immunotherapies; target tumor hypoxia; hypoxia-targeting prodrugs; perfluorocarbons; injectable oxygen microparticles
(This special issue belongs to the Section Molecular Pharmacology)
Molecular Research on Pharmacogenetics
edited by Stefania Cheli
submission deadline 30 May 2024 | Viewed by 112 | Submission Open
Keywords: pharmacogenetics; pharmacokinetics; pharmacodynamics; genotype; haplotype; biomarker; single-nucleotide polymorphism; genomic variant; genetic testing; adverse drug reactions; clinical implementation
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Recent Research on Vitamin D Metabolism in Disease
edited by Arnaud Molin
submission deadline 30 May 2024 | Viewed by 108 | Submission Open
Keywords: vitamin D; vitamin D receptor; vitamin D metabolizing enzyme; vitamin D metabolism; vitamin D regulation; calcium– phosphate homeostasis; cell differenciation; cell proliferation
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Microbial Biofilms in Host Immune Responses and Antimicrobial Therapy
edited by Mayri Alejandra Díaz De Rienzo
submission deadline 30 May 2024 | Viewed by 104 | Submission Open
Keywords: biofilms; immune response; antimicrobial resistance; disruption; quorum sensing; host interactions
(This special issue belongs to the Section Molecular Microbiology)
Recent Advances in Hypertension and Cardiovascular Disease
edited by Edyta Zbroch
submission deadline 31 May 2024 | 7 articles | Viewed by 24039 | Submission Open
Keywords: hypertension; hypertension pathophysiology; hypertension molecular mechanisms; cardiovascular disease; cardiovascular pathophysiology; cardiovascular molecular mechanisms; cardiovascular biomarkers; heart failure; coronary artery disease; chronic kidney disease
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular and Translational Research in Cardiovascular Endocrinology, Cardio-Metabolic Diseases and Non-alcoholic Fatty Liver Disease (NAFLD) submission deadline 31 May 2024 | 9 articles | Viewed by 16295 | Submission Open
Keywords: cardiovascular endocrinology; atherosclerosis; coronary artery disease; endocrine hypertension; non-alcoholic fatty liver disease (NAFLD); diabetes mellitus and obesity; metabolic syndrome; endothelial cells; vascular inflammation; antidiabetic drugs; antihypertensive treatments; lipid-lowering treatments; lifestyle interventions; molecular targeted therapies; heart failure; chronic kidney disease
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Recent Advances in Molecular Breeding for Drought and Salt Stress Tolerance in Crops
edited by
submission deadline 31 May 2024 | 8 articles | Viewed by 14509 | Submission Open
Keywords: drought; salt; heat; cold; gene regulation; genomic research; multiomics; epigenetics; stress signal transduction
(This special issue belongs to the Section Molecular Plant Sciences)
Mechanisms and Means of Immune Modulation in Innate and Adaptive Immunity submission deadline 31 May 2024 | 7 articles | Viewed by 11506 | Submission Open
Keywords: immune checkpoints; innate immunity; adaptive immunity; modulation
(This special issue belongs to the Section Molecular Immunology)
Molecular Breeding for Abiotic Stress Tolerance in Crops
edited by
submission deadline 31 May 2024 | 6 articles | Viewed by 11218 | Submission Open
Keywords: plant breeding; advance molecular approach; molecular characterization; environmental stresses; plant tolerance; resistant genes; QTLs; drought; salinity; climatic changes
(This special issue belongs to the Section Molecular Plant Sciences)
Natural Active Compounds from Foods: Applications in Antioxidant and Bioactivity Evaluation submission deadline 31 May 2024 | 7 articles | Viewed by 10685 | Submission Open
Keywords: polyphenols; omega-3 fatty acids; gelatin; fucoidans; chitosan; chondroitin sulfate; enzyme; antioxidant; anti-inflammatory
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Dendritic Cell and Cancer Therapy 2.0
edited by
submission deadline 31 May 2024 | 5 articles | Viewed by 10603 | Submission Open
Keywords: dendritic cells; dendritic cell subsets; cancer immunotherapy; immune suppression; cancer vaccines; anti-cancer response; tumor microenvironment
(This special issue belongs to the Section Molecular Immunology)
Targeting CAR T-cell Therapy: Molecular Research and Its Future Implication
edited by
submission deadline 31 May 2024 | 4 articles | Viewed by 10328 | Submission Open
Keywords: CAR T-cell therapy; malignant diseases; molecular pathways; CAR T-related toxicities; resistance mechanisms
(This special issue belongs to the Section Molecular Immunology)
Retinal Diseases: From Molecular Pathology to Therapies
edited by
submission deadline 31 May 2024 | 7 articles | Viewed by 9389 | Submission Open
Keywords: diabetic retinopathy; age-related macular degeneration; neuroprotection; retina; diabetic macular edema; therapy development; pathophysiology; retinitis pigmentosa; aging; eye trauma; vitreous; macula; choroideremia; Stargardt disease; cone-rod dystrophy; Leber congenital amaurosis; best vitelliform macular dystrophy
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Genetics and Multi-Omics for Crop Breeding submission deadline 31 May 2024 | 7 articles | Viewed by 9227 | Submission Open
(This special issue belongs to the Section Molecular Plant Sciences)
The Molecular Basis of Extracellular Vesicles in Health and Diseases
edited by Taral R. Lunavat
submission deadline 31 May 2024 | 6 articles | Viewed by 8773 | Submission Open
Keywords: exosomes; microvesicles; extracellular vesicles; genetic material; therapeutics; diagnostics; biomarkers; molecular pathway; liquid biopsy; metabolism; omics
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Hormone Signaling in Cancers and Cancer-Promoting Pathologies
edited by
submission deadline 31 May 2024 | 4 articles | Viewed by 7830 | Submission Open
Keywords: estrogen; androgen; thyroxine; thyroid hormones; adrenalin; adrenocorticoids; progesterone; medroxyprogesterone; mifepristone; corticosteroids; glucocorticoids; mineralocorticoids; testosterone; cortisol; prednisolone; hormones; hormone receptors; endocrine-related cancers; hormone therapy; hormone therapy resistance; drug resistance; epigenetics; microRNA
(This special issue belongs to the Section Molecular Oncology)
Role of Dopamine in Health and Disease: Biological Aspect 2.0 submission deadline 31 May 2024 | 7 articles | Viewed by 7614 | Submission Open
Keywords: dopamine; addiction; neurophysiology; dopaminergic system; neurotransmitter
(This special issue belongs to the Section Molecular Neurobiology)
Antibacterial Strategies in Biomaterials: Current Progress and Challenges 2.0
edited by
submission deadline 31 May 2024 | 6 articles | Viewed by 7413 | Submission Open
Keywords: nanobiomaterials; antimicrobial nanoparticles; biofilm modulation; surfaces and coatings to control bacterial attachment; molecules and nanodrugs; drug delivery; multifunctional materials; infection control; vaccines for drug resistant bacteria
(This special issue belongs to the Section Materials Science)
Molecular Mechanisms of Somatic Cell Cloning and Other Assisted Reproductive Technologies in Mammals submission deadline 31 May 2024 | 5 articles | Viewed by 7372 | Submission Open
Keywords: somatic cell nuclear transfer (SCNT); SCNT-based cloning; assisted reproductive technology (ART); in vitro embryo production (IVP); in vitro fertilization (IVF); intracytoplasmic sperm injection (ICSI); in vivo embryo production
(This special issue belongs to the Section Molecular Biology)
Regulation and Targeting of Ferroptosis in Tumor and Beyond
edited by and Jin Xie
submission deadline 31 May 2024 | 5 articles | Viewed by 7309 | Submission Open
Keywords: ferroptosis; iron; tumor survival and cell death; oxidation; drug development; anticancer strategies
(This special issue belongs to the Section Molecular Oncology)
Cutaneous Biology, Molecular Dermatology and Dermatopathology
edited by
submission deadline 31 May 2024 | 4 articles | Viewed by 6938 | Submission Open
Keywords: molecular dermatology; targeted therapy; cutaneous oncology; immunodermatology; cutaneous biology
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Focus on Hippocampus Biology: From Neurophysiology to Dysfunctions
edited by
submission deadline 31 May 2024 | 6 articles | Viewed by 6832 | Submission Open
Keywords: hippocampus; dentate gyrus; cornu ammonis (CA); spatial memory; episodic memory; learning; spatial navigation; synaptic plasticity; neuroplasticity; neurogenesis; ischemia; neuroinflammation; chronic stress; aging; neurodegenerative diseases; Alzheimer’ s disease; epilepsy; depression; anxiety
(This special issue belongs to the Section Molecular Neurobiology)
Molecular Diagnostics and Therapeutic Target in Bladder Cancer
edited by Hideki Furuya
submission deadline 31 May 2024 | 6 articles | Viewed by 6568 | Submission Open
Keywords: non-muscle invasive bladder cancer; muscle invasive bladder cancer; metastatic bladder cancer; diagnostic biomarkers; therapeutic targets
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
The Role of Omics and Artificial Intelligence for the Personalized Management of Inflammatory and Neoplastic Digestive Diseases submission deadline 31 May 2024 | 3 articles | Viewed by 6324 | Submission Open
Keywords: systems medicine; big data; data harmonization and integration; artificial intelligence; inflammatory digestive diseases; neoplastic digestive diseases
(This special issue belongs to the Section Molecular Informatics)
Oral Soft Tissue Repair and Oral Diseases
edited by
submission deadline 31 May 2024 | 6 articles | Viewed by 6120 | Submission Open
Keywords: oral medicine; tissue regeneration; lasers; photobiomodulation; periodontology; implant dentistry
(This special issue belongs to the Section Molecular Biology)
Design, Synthesis, and Mechanism of Fluorescent and Luminescent Materials submission deadline 31 May 2024 | 5 articles | Viewed by 5753 | Submission Open
Keywords: luminiscent materials; molecular design and synthesis; supramolecular chemistry; emissive mechanisms and processes; photophysics; photochemistry; probes and sensors; optoelectronics
(This special issue belongs to the Section Materials Science)
Biomolecular Structure, Function and Interactions
edited by
submission deadline 31 May 2024 | 7 articles | Viewed by 5636 | Submission Open
Keywords: biophysical chemistry; protein– protein interactions; protein– DNA interactions; protein– ligand interactions; receptor– ligand interactions; biomolecular structure and function; protein folding and stability
(This special issue belongs to the Section Biochemistry)
Fifty Years of Targeted Therapy in Cancer: Past, Present and Future
edited by
submission deadline 31 May 2024 | 3 articles | Viewed by 5593 | Submission Open
Keywords: tumor microenvironment; immune suppression; targeted therapy; immune checkpoint blockers; epigenetic regulators; macrophage polarization; cancer stem cells; therapeutic resistance; tumor immune microenvironment; immunotherapy; repurposed drugs; oxidative stress
(This special issue belongs to the Section Molecular Oncology)
Wound Repair and Regeneration 2023
edited by
submission deadline 31 May 2024 | 4 articles | Viewed by 5488 | Submission Open
Keywords: wound healing; inflammation; scarring; extracellular matrix; regeneration; biomaterials; chronic wounds; remodeling; stem cells; growth factors; disease; pathophysiology; therapy; tissue engineering
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Computer-Aided Drug Design Strategies
edited by
submission deadline 31 May 2024 | 6 articles | Viewed by 5424 | Submission Open
Keywords: artificial intelligence; machine learning; cheminformatics; docking; molecular dynamics; homology modeling; pharmacophore modeling; QSAR; ligand-based similarity
(This special issue belongs to the Section Molecular Informatics)
Molecular Research in Neurodevelopmental Disorders
edited by
submission deadline 31 May 2024 | 4 articles | Viewed by 5341 | Submission Open
Keywords: neurodevelopmental disorders; genetics; molecular pathways; neural development; neurogenesis; animal models
(This special issue belongs to the Section Molecular Neurobiology)
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