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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic. The journal’s Editor-in-Chief and/or designated EBM will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Molecular Mechanisms and Therapies of Pancreatic Cancer submission deadline 15 May 2024 | 13 articles | Viewed by 18310 | Submission Open
Keywords: pancreatic cancer; metabolism; cellular plasticity; tumor microenvironment; target therapy
(This special issue belongs to the Section Molecular Oncology)
Cannabis sativa: From Plants to Humans submission deadline 15 May 2024 | 7 articles | Viewed by 17776 | Submission Open
Keywords: Cannabis sativa; hemp; fiber; biofuel; cannabinoids; nutritional quality; health benefits; phytoremediation
(This special issue belongs to the Section Molecular Biology)
Transcriptional Regulation of Late Oogenesis and Early Embryogenesis submission deadline 15 May 2024 | 10 articles | Viewed by 16738 | Submission Open
Keywords: transcription activity of oocytes; zygotes and early embryos; transcriptomes of oocytes and early embryos; chromatin remodeling; histone and non-histone proteins; coding and non-coding RNAs; DNA methylation
(This special issue belongs to the Section Molecular Biology)
Molecular Mechanisms of Toxic and Activated Effects of Exogenous Compounds submission deadline 15 May 2024 | 10 articles | Viewed by 14666 | Submission Open
Keywords: exogenous compounds; bioeffects; toxicity; low-concentration exposures; high concentrations exposures; low-dose effects; activated effects
(This special issue belongs to the Section Biochemistry)
Calcium Signaling in Mammalian Cells: From Physiology to Pathology
edited by
submission deadline 15 May 2024 | 6 articles | Viewed by 12849 | Submission Open
Keywords: Ca2+ signaling; excitable cells; Ca2+ transporting systems; calcium-binding proteins; calcium dysregulation; signal transduction; G-protein coupled receptors; apoptosis
(This special issue belongs to the Section Biochemistry)
Molecular Genetics of Drosophila Development
edited by
submission deadline 15 May 2024 | 12 articles | Viewed by 12770 | Submission Open
Keywords: Drosophila development; metamorphosis; imaginal discs; differentiation; tissue specification; regeneration; proliferation; neural stem cells; nuclear receptor; ecdysone cascade; hippo signalling pathway; notch signalling pathway; hedgehog signalling pathway; wnt/wingless signalling pathway  
(This special issue belongs to the Section Molecular Genetics and Genomics)
Molecular Research on Autophagy
edited by
submission deadline 15 May 2024 | 7 articles | Viewed by 12751 | Submission Open
Keywords: ATG molecules; transcriptional and post translational modification; selective pathways; secretory pathways; complexes diseases; degenerative processes; inflammatory diseases; tumorigenesis; metabolism; proteostasis
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Recent Molecular Research on Preeclampsia submission deadline 15 May 2024 | 11 articles | Viewed by 12733 | Submission Open
Keywords: preeclampsia; molecular signaling; transcription factors; translational regulation; genetic predisposition; epigenetic regulation; angiogenic markers; inflammation markers; metabolomics; transcriptomics
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Pharmacological Activities of Secondary Metabolites and Derivates of Medicinal Plants around the World
edited by
submission deadline 15 May 2024 | 7 articles | Viewed by 12316 | Submission Open
Keywords: natural products; secondary metabolites; medicinal chemistry; worldwide traditional medicine; isolation and identification of secondary metabolites; experimental studies; phytochemistry; pharmacognosy; medicinal plants
(This special issue belongs to the Section Molecular Pharmacology)
Fish Genomics and Developmental Biology submission deadline 15 May 2024 | 9 articles | Viewed by 11433 | Submission Open
Keywords: genomics; development; teleost; aquaculture; transcriptomics; gene expression; environment; genomes; comparative genomics; population genomics; selective breeding; biomarker
(This special issue belongs to the Section Molecular Biology)
Whole-Cell System and Synthetic Biology
edited by and
submission deadline 15 May 2024 | 6 articles | Viewed by 10709 | Submission Open
Keywords: synthesis biology; molecular biology; functional nucleic acids; biosensor; CRISPR-Cas; directed evolution; whole-cell system
(This special issue belongs to the Section Molecular Biology)
Transcriptional Regulation and Its Misregulation in Human Diseases: Recent Progress submission deadline 15 May 2024 | 5 articles | Viewed by 10590 | Submission Open
Keywords: transcription machinery; transcription factors; transcription cofactors and complexes; chromatin regulators; splicing regulators; noncoding RNAs; posttranscriptional modifications; transcription misregulation; genetic alterations; human diseases
(This special issue belongs to the Section Molecular Biology)
Recent Advances in Molecular Mechanisms of Human Papillomavirus Family (HPV) Induced Oncogenesis
edited by
submission deadline 15 May 2024 | 5 articles | Viewed by 10292 | Submission Open
Keywords: human papillomavirus (HPV); oncogenesis; mechanism; diagnosis; classification; etiology; pathophysiology; biochemistry; genetics; molecular biology; epidemiology; cervical cancer; oropharyngeal cancer; oncology
(This special issue belongs to the Section Molecular Oncology)
Hormone Receptor in Breast Cancer submission deadline 15 May 2024 | 7 articles | Viewed by 10065 | Submission Open
Keywords: estradiol; progesterone; calcitriol; androgen; resveratrol; phytoestrogens; therapeutic targets; fulvestrant; treatment response; SERM; estrogen receptor isoforms; selective ligands; hormonal carcinogenesis; breast cancer prevention; hormone signaling; endocrine disruptor compounds; ER-negative breast cancer; ER-positive breast cancer; aromatase inhibitors
(This special issue belongs to the Section Molecular Endocrinology and Metabolism)
Cellular Crosstalk in the Tumor Microenvironment submission deadline 15 May 2024 | 4 articles | Viewed by 9439 | Submission Open
Keywords: cancer; metastasis; inflammation; cancer-associated fibroblasts; biomarkers; multiplex imaging; in vitro models; animal models; immunotherapy
(This special issue belongs to the Section Biochemistry)
Advances in Melanoma and Skin Cancers
edited by , and Maria Grazia Vitale
submission deadline 15 May 2024 | 7 articles | Viewed by 9328 | Submission Open
Keywords: melanoma; immunotherapy; biomarkers; translational research; drug repurposing; prognostic markers; predictive markers; combination immunotherapy
(This special issue belongs to the Section Molecular Oncology)
New Agents and Novel Drugs Use for the Oncological Diseases Treatment submission deadline 15 May 2024 | 8 articles | Viewed by 9241 | Submission Open
Keywords: anti-proliferative; cancer; molecular oncology; novel agents; off-label use; target therapy
(This special issue belongs to the Section Molecular Pharmacology)
Therapeutic Modulation of Mesenchymal Stem Cell for Effective Regenerative Medicine
edited by
submission deadline 15 May 2024 | 5 articles | Viewed by 9069 | Submission Open
Keywords: stem cells; cell senescence; stem cell differentiation; adipogenesis; osteogenesis; cardiogenesis; conditioned media; epigenetics; biomarkers; cell-based therapies; malignant transformation
(This special issue belongs to the Section Molecular Biology)
Application of Nanostructures in Biology and Medicine
edited by
submission deadline 15 May 2024 | 5 articles | Viewed by 8831 | Submission Open
Keywords: materials science; synthetic biology; biotechnology; cell biology; metagenomics; bioimaging; nanostructures; nanodevices; green nanotechnology
(This special issue belongs to the Section Molecular Nanoscience)
Novel Therapeutic Targets of Solid Cancer
edited by
submission deadline 15 May 2024 | 5 articles | Viewed by 8479 | Submission Open
Keywords: cancer; signal transduction; kinase inhibitors; targeted therapy; precision medicine; drug resistance; survival; cell cycle; cell reprogramming; stem cells; immunotherapy
(This special issue belongs to the Section Molecular Oncology)
Latest Advances on Nanoparticles for Modern Biomedicine submission deadline 15 May 2024 | 8 articles | Viewed by 8370 | Submission Open
Keywords: nanomedicine; nanotechnology; cancer; nanotheranostics; targeted therapy; laser-ablative synthesis; drug delivery; imaging
(This special issue belongs to the Section Molecular Nanoscience)
Plant Response to Insects and Microbes 2.0
edited by
submission deadline 15 May 2024 | 7 articles | Viewed by 8005 | Submission Open
Keywords: plants; defense response; arthropods; bacteria; fungi; viruses; biotic stress
(This special issue belongs to the Section Molecular Plant Sciences)
Advances in Molecular Research on Autoimmune Diseases
edited by
submission deadline 15 May 2024 | 7 articles | Viewed by 7495 | Submission Open
Keywords: autoimmune markers; immunology; pathogenesis; immunogenetics; animal models; immunotherapy
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Systemic and Mucosal Inflammation in Colorectal Cancer: Underlying Factors, Significance, and Related Biomarkers
edited by
submission deadline 15 May 2024 | 5 articles | Viewed by 7237 | Submission Open
Keywords: molecular changes; colorectal cancer; normal mucosa; apoptotic proteins; inflammatory mechanism; adenoma– carcinoma sequence; cancer biomarkers
(This special issue belongs to the Section Molecular Oncology)
Molecular Mechanisms of Plant Defense against Abiotic Stress 2.0
edited by
submission deadline 15 May 2024 | 5 articles | Viewed by 7148 | Submission Open
Keywords: abiotic stress; antioxidant activity; chlorophyll fluorescence; environmental pollution; photosynthesis; photosynthetic machinery; plant responses; plant tolerance; reactive oxygen species; thylakoid membranes; photosynthetic machinery; signal molecules
(This special issue belongs to the Section Molecular Plant Sciences)
Inflammation in Skin and Joints submission deadline 15 May 2024 | 4 articles | Viewed by 7004 | Submission Open
Keywords: inflammatory skin conditions; inflammation in joints; psoriasis; psoriatic arthritis; rheumatoid arthritis; collagen-induced arthritis; dermatitis; barrier function; angiogenesis; keratinocytes; inflammatory cells; immune cells
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Gastrointestinal Diseases: Molecular Mechanism, Diagnostics, and Novel Therapeutic Approaches
edited by
submission deadline 15 May 2024 | 6 articles | Viewed by 6859 | Submission Open
Keywords: gut microbiota; gut– brain axis; drug metabolism; drug delivery systems; drug resistance; gut barrier function; gut hormones; intestinal permeability; molecular diagnostics; biomarkers; molecular genetic profiling; molecular imaging modalities; molecular therapeutic targets; nanomedicine; molecular immunotherapy; molecular basis of immune response; molecular gene therapy; molecular mechanisms; genomics/epigenomics; next-generation sequencing; tumor microenvironment; DNA repair/methylation; animal models; signaling pathway
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
New Types of Antimicrobial Biocides
edited by
submission deadline 15 May 2024 | 6 articles | Viewed by 6840 | Submission Open
Keywords: biocides; pathogen; cross-resistance; infection
(This special issue belongs to the Section Molecular Pharmacology)
Molecular Mechanisms of Sjögren's Syndrome 3.0 submission deadline 15 May 2024 | 5 articles | Viewed by 6784 | Submission Open
Keywords: autoimmunity; Sjö gren’ s syndrome; autoantibodies; salivary gland; lacrimal gland; dry eyes/mouth  
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
The Zebrafish Model in Animal and Human Health Research submission deadline 15 May 2024 | 6 articles | Viewed by 6783 | Submission Open
Keywords: zebrafish; environmental toxicology; predictive toxicology
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Technology Advance and Application of Cryo-Electron Microscopy in Molecular Biology and Biomedicine
edited by and Jesús Gerardo Galaz-Montoya
submission deadline 15 May 2024 | 2 articles | Viewed by 6140 | Submission Open
Keywords: cryo-electron microscopy (cryo-EM)  ; cryo-electron tomography (cryo-ET)  ; cryo-EM sample preparation  ; single-particle analysis  ; sub-tomogram averaging  ; structural determination  ; molecular machines  ; structural dynamics  ; structure-based drug discovery  ; machine learning  ; conformational states  ; conformational landscape  ; conformational continuum  ; time-resolved cryo-EM  ; atomic modeling
(This special issue belongs to the Section Molecular Biophysics)
Cellular Responses to Environmental Changes
edited by
submission deadline 15 May 2024 | 5 articles | Viewed by 6075 | Submission Open
Keywords: environment sensing; cellular stress response; (bio)chemical environment; (bio)physical environment; mechanical environment; thermal environment; radiation; enviromics; receptors; signal transduction pathways
(This special issue belongs to the Section Molecular Biology)
The Role of Specific Alteration in Neurological Disorders: From Molecular Mechanisms to Therapeutic Strategies submission deadline 15 May 2024 | 3 articles | Viewed by 6014 | Submission Open
Keywords: neurological disorders; neurodevelopmental disorders; cellular neurophysiology; brain; molecular therapy; gene therapy; animal models; motor control
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Hepatocellular Carcinoma in 2023: What Is New on Pathogenesis, Diagnosis and Treatment submission deadline 15 May 2024 | 2 articles | Viewed by 5895 | Submission Open
Keywords: liver cancer; hepatocellular carcinoma; hepatitis B virus; hepatitis C virus; nonalcoholic fatty liver disease; HBV; HCV; HCC; NAFLD; tumor microenvironment; gut liver axis
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Mechanisms and Pathophysiology of Myocardial Disease submission deadline 15 May 2024 | 3 articles | Viewed by 5347 | Submission Open
Keywords: myocardiac disease; cardiomyopathy; fibrosis; heart failure; comorbidity; molecular mechanisms; pathophysiology
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
(Meta)Genomic, Functional, Structural and Evolutionary Analysis of Transport Systems
edited by , Milton Saier and Gabriel Moreno-Hagelsieb
submission deadline 15 May 2024 | 3 articles | Viewed by 4949 | Submission Open
Keywords: molecular transport; transport mechanisms; evolution; families and superfamilies; genomics; metagenomics; 3D structural insights; bioinformatics
(This special issue belongs to the Section Molecular Biology)
Alzheimer's Disease: From Pathogenic Mechanisms to Therapy
edited by Jordi Olloquequi and
submission deadline 15 May 2024 | 3 articles | Viewed by 4938 | Submission Open
Keywords: neurodegeneration; pathogenesis; biomarkers; therapeutics; drug development; clinical trials; translational research; genetics; epigenetics
(This special issue belongs to the Section Molecular Neurobiology)
New Cardiovascular Risk Factors
edited by
submission deadline 15 May 2024 | 4 articles | Viewed by 4509 | Submission Open
Keywords: atherosclerosis; cardiovascular risk; arterial stiffness; blood pressure; vitamin D; miRNA; inflammation
(This special issue belongs to the Section Molecular Biology)
The Structures and Biologic Activity of Marine Natural Products submission deadline 15 May 2024 | 3 articles | Viewed by 4497 | Submission Open
Keywords: marine natural products; secondary metabolites; structure elucidation; biologic activity; structure-activity relationships; taxonomic distribution; biosynthesis; functions
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Molecular Advances in Orthopedic Trauma and Therapy
edited by
submission deadline 15 May 2024 | 3 articles | Viewed by 4039 | Submission Open
Keywords: regenerative medicine; molecular diagnostics; biomaterials; cartilage repair; bone healing; meniscal lesions; tendons and ligament injuries; cell therapy; gene therapy; tissue engineering
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
New Insights into Antimicrobial Nanoparticles: From Mechanisms to Applications
edited by
submission deadline 15 May 2024 | 3 articles | Viewed by 3967 | Submission Open
Keywords: antimicrobial nanoparticles; alternative to antibiotics; physical and chemical activation of nanoparticles; multi-drug resistance; mechanisms of anti-infective action
(This special issue belongs to the Section Molecular Nanoscience)
New Advances in Molecular Research of Coronavirus submission deadline 15 May 2024 | 3 articles | Viewed by 3942 | Submission Open
Keywords: COVID-19; pathogenesis; SARS-CoV-2 receptors; drug repurposing; drug targets and potential treatments; prevention of post-COVID syndrome; thrombosis; kidney disease
(This special issue belongs to the Section Molecular Immunology)
Translational and Molecular Research of Neurological Disorders submission deadline 15 May 2024 | 2 articles | Viewed by 3863 | Submission Open
Keywords: molecular pathways; neurological disorders; neurodegeneration; animal models; pathogenesis; neurogenetics; biomarkers
(This special issue belongs to the Section Molecular Neurobiology)
Molecular Research on Parasites and the Host Immune Response
edited by
submission deadline 15 May 2024 | 2 articles | Viewed by 3121 | Submission Open
Keywords: parasites; immune response; immunomodulation; vaccines; helminths; nervous system and parasitic infection
(This special issue belongs to the Section Molecular Microbiology)
Interaction of Nanomaterials with the Immune System 3.0
edited by
submission deadline 15 May 2024 | 4 articles | Viewed by 3091 | Submission Open
Keywords: nanomaterials; nanoparticles; nanomedicines; immune system; infection; inflammation; allergy; autoimmunity
(This special issue belongs to the Section Molecular Nanoscience)
Sirtuins as Players in Cell Metabolism and Functions submission deadline 15 May 2024 | 3 articles | Viewed by 2915 | Submission Open
Keywords: sirtuins; epigenetics effects; SIRT modulators; neurodegeneration; neuroprotection and neuroimmunology; control of reproduction; cell metabolism; ageing; immunomodulation
(This special issue belongs to the Section Biochemistry)
Chemical Applications of Excited States: Method Development and Current Progress
edited by
submission deadline 15 May 2024 | 3 articles | Viewed by 2887 | Submission Open
Keywords: quantum chemistry; excited states; light absorption; light emission; fluorescence; phosphorescence; nonradiative processes; photophysics; photochemistry; energy transfer; charge transfer; photoinduced proton transfer; excited state dynamics
(This special issue belongs to the Section Physical Chemistry and Chemical Physics)
Advanced Molecular Research in Lung Diseases
edited by
submission deadline 15 May 2024 | 2 articles | Viewed by 2796 | Submission Open
Keywords: lung diseases; cellular processes; molecular mechanisms; new drug discoveries; novel treatment options
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Polymers in Biological Systems
edited by
submission deadline 15 May 2024 | 2 articles | Viewed by 2727 | Submission Open
Keywords: natural polymers; biomimetic properties; biocompatibility; biodegradability; mechanical properties; cells; cell cultures; tissues; organs; microbial communities
(This special issue belongs to the Section Materials Science)
Molecular Dynamics of Membrane Proteins
edited by
submission deadline 15 May 2024 | 3 articles | Viewed by 2674 | Submission Open
Keywords: molecular dynamics; force fields; membrane proteins; macromolecular crowding; oligomerization; coarse-graining; enhanced sampling; lipid– protein interactions
(This special issue belongs to the Section Molecular Biophysics)
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