Special Issue "Advances in Molecular Pathology"


A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology".

Deadline for manuscript submissions: closed (30 November 2011)

Special Issue Editor

Guest Editor
Prof. Dr. Paul Fisch
Institute of Pathology, University Hospital Freiburg, Breisacher Strasse 115a, 79106 Freiburg, Germany
E-Mail: paul.fisch@uniklinik-freiburg.de

Special Issue Information

Dear Colleagues,

Molecular pathology is a medical subspecialty, increasingly localized between pathology and clinical medicine. Why may this somewhat provocative view be justified? Molecular pathology got its start in the last 10 to 20 years of the last century as a field with the primary goal of aiding pathologists in making the right diagnosis in difficult cases or to find out whether a lesion is neoplastic or reactive. Initially, PCR-based methods were developed that worked on paraffin material allowing the determination of clonality of immunoglobulin or T-cell receptor genes in lymphoid neoplasia, or even in nonlymphoid tissues such as myeloid proliferations or endometriosis using HUMARA. In parallel, RT-PCR and later Q-PCR from cDNA or FISH- based techniques became extremely useful methods to look for gene-fusions such as BCR-ABL and EWS-FLI1 in leukemias and sarcomas, or Q-PCR from DNA to find JAK2 mutations in myeloproliferative and myelodysplastic syndromes. Besides hematology and oncology, a considerable overlap has developed with microbiology, when looking for mycobacteria and other infectious agents in human tissues by PCR, and even with medical genetics, when looking for microsatellite instability in HNPCC or for the diagnosis of hemochromatosis. “Molecular pathology” in recent years is also becoming a tool for basic scientists and, lately for clinicians to look for minimal residual disease, determine prognosis and chose the best therapy. Examples for the latter are the analysis of mutations of KRAS in colon cancer, EGFR in lung cancer or CKIT in GIST as predictive markers. Novel technologies such as oligonucleotide arrays, whole genome sequencing and cDNA microarrays allow genomic analysis and gene expression profiling of tumor entities. They have the potential to revolutionize disease nomenclature, to better understand disease pathogenesis, help in treatment decisions and more accurately determine prognosis. On the other hand, rate limiting steps are the costs of these novel technologies in research and clinical applications and the need for effective cooperation between the departments of pathology, basic sciences, microbiology, virology, genetics, biometry/statistics, as well as clinical medicine.

Prof. Dr. Paul Fisch
Guest Editor


  • microarrays
  • whole genome sequencing
  • predictive markers
  • minimal residual disease
  • PCR
  • FISH
  • disease pathogenesis
  • predictive markers

Published Papers (4 papers)

by , , , , ,  and
Int. J. Mol. Sci. 2012, 13(2), 2331-2353; doi:10.3390/ijms13022331
Received: 6 December 2011; in revised form: 9 February 2012 / Accepted: 13 February 2012 / Published: 21 February 2012
Show/Hide Abstract | Cited by 5 | PDF Full-text (368 KB) | HTML Full-text | XML Full-text

Int. J. Mol. Sci. 2012, 13(2), 1951-2011; doi:10.3390/ijms13021951
Received: 2 December 2011; in revised form: 23 January 2012 / Accepted: 1 February 2012 / Published: 13 February 2012
Show/Hide Abstract | Cited by 12 | PDF Full-text (737 KB) | HTML Full-text | XML Full-text

by , , , ,  and
Int. J. Mol. Sci. 2012, 13(2), 1632-1643; doi:10.3390/ijms13021632
Received: 23 November 2011; in revised form: 16 January 2012 / Accepted: 17 January 2012 / Published: 2 February 2012
Show/Hide Abstract | Cited by 5 | PDF Full-text (330 KB) | HTML Full-text | XML Full-text

by , , , , ,  and
Int. J. Mol. Sci. 2011, 12(11), 7424-7437; doi:10.3390/ijms12117424
Received: 8 August 2011; in revised form: 12 October 2011 / Accepted: 19 October 2011 / Published: 28 October 2011
Show/Hide Abstract | Cited by 10 | PDF Full-text (596 KB) | HTML Full-text | XML Full-text

Last update: 26 February 2014

Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert