Special Issue "Bone Metastasis: Pathophysiology and Molecular Mechanisms"
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: 30 September 2018
Bone metastases, common features of advanced breast and prostate cancer, are increasingly also found in patients with other cancers (e.g., lung) due to improved treatment of the primary tumour and, hence, prolonged survival. However, once skeletal involvement is established, patient survival is limited and treatment often limited to palliation. The main current therapies are bone-targeted agents to prevent and/or reduce skeletal related events like fractures and spinal cord compression. However, no treatment specifically prevents the development of bone metastases. Novel therapeutic approaches to improve outcome for these poor prognosis patients require a better understanding of the molecular and cellular mechanisms that underpin tumour cell dissemination, colonisation and progression in bone. In particular, the role of the bone microenvironment in regulation of cancer cell dormancy, as well as identification of the signals that trigger escape from dormancy, remain to be elucidated. Another main area of interest is how tumour cell interactions with the bone microenvironment represents novel therapeutic targets, in particular in relation to new treatment modalities like immunotherapy.
This Special Issue will contain a collection of manuscripts that describe investigations into the different stages of bone metastasis, covering a range of model systems and tumour types, reflecting our current knowledge.
Prof. Dr. Ingunn Holen
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- bone microenvironment
- bone metastases
- breast cancer
- disseminated tumour cells
- extracellular matrix
- lung cancer
- prostate cancer
- tumour cell dormancy
The below list represents only planned manuscripts. Some of these manuscripts have not been received by the Editorial Office yet. Papers submitted to MDPI journals are subject to peer-review.
Title: Disordered arrangement of collagen fiber/apatite crystal is controlled by the intercellular interactions between cancer cells and osteoblasts; A novel determiner for mechanical dysfunction in metastasized bone
Authors: Aira Matsugaki, Aiko Sekita, Tatsuki Harada and Takayoshi Nakano*
Abstract: The deepest mystery of bone metastasis is why cancer weakens the targeted bone separately from the alteration in bone mass. The mechanical dysfunction accompanied with the increased risk of pathological fracture occurs both in osteoblastic and osteolytic metastasis, indicating that the alteration in bone mass cannot explain the mechanical disorders induced by cancer involvement. Intact bone tissue exhibits a characteristic anisotropic microstructure based on collagen fiber alignment and the related c-axis orientation of apatite crystals, which is derived from the intercellular molecular events mediating the cellular arrangement. Here we demonstrate that the disorganized, less-aligned microstructure in cancer-bearing bone matrix is a dominant determiner for disruption of bone mechanical function. Also, a novel mechanism underlying the disorganization of metastasized bone matrix is proposed, dynamic interactions between cancer cells and osteoblasts disturb the osteoblast arrangement along collagen substrate. The present findings indicate that the bone matrix anisotropy is an important new index for assessment of mechanical dysfunction in metastasized bone.