Special Issues

Genes publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Genetics and Genomics of Heritable Pediatric Disorders submission deadline 25 Oct 2025 | 8 articles | Viewed by 12262
Keywords: human genetics; genomics; rare diseases; pediatric disorders; genetics
(This special issue belongs to the Section Molecular Genetics and Genomics)
Genetics of Neuropsychiatric Disorders
edited by Melloni Cook and Kristin Hamre
submission deadline 25 Oct 2025 | 6 articles | Viewed by 6170
Keywords: major depressive disorder; schizophrenia; post-traumatic stress disorder; addiction; alcohol; drugs; anxiety disorder; stress-related disorders; genes; epigenetics; mRNA; optogenetics; miRNA; causal variant
(This special issue belongs to the Section Molecular Genetics and Genomics)
The Molecular Breeding of Vegetables: Technological Innovations and Breeding Practices
edited by
submission deadline 25 Oct 2025 | Viewed by 241
Keywords: vegetable breeding; marker-assisted selection; gene editing; genomic selection; trait improvement; omics technologies; disease and stress resistance
(This special issue belongs to the Section Plant Genetics and Genomics)
Chromatin Remodeling and DNA Repair Pathways in Cancer
edited by
submission deadline 25 Oct 2025 | Viewed by 222
Keywords: chromatin remodeling; chromatin remodelers; nucleosome; histone modification; DNA damage responses
(This special issue belongs to the Section Human Genomics and Genetic Diseases)
Opportunities and Prospects of Cancer Gene Therapy
edited by Ruoxi Zhang
submission deadline 25 Oct 2025 | Viewed by 200
Keywords: cancer gene therapy; tumor suppressor gene activation; oncogene inhibition; suicide gene therapy; antiangiogenic gene therapy; immunogenic therapy; viral and non-viral vectors; targeted gene delivery; translational cancer research
(This special issue belongs to the Section Human Genomics and Genetic Diseases)
The Opportunities and Challenges of Next-Generation Sequencing in Cancer Biology
edited by and Taslim Al-Hilal
submission deadline 25 Oct 2025 | Viewed by 176
Keywords: bioinformatics; DNA-seq; RNA-seq; Chip-seq; epigenomics
(This special issue belongs to the Section Human Genomics and Genetic Diseases)
Differentially Expressed Genes (DEGs) and Regulatory Network in Response to Various Abiotic Stresses in Plants
edited by Xuke Lu
submission deadline 30 Oct 2025 | 1 articles | Viewed by 906 | Submission Open
Keywords: plants; abiotic stresses; molecular mechanism; differentially expressed genes (DEGs); regulatory network
(This special issue belongs to the Section Plant Genetics and Genomics)
Genetics and Epigenetics in Susceptibility to Multifactorial Diseases
edited by and Andrea Latini
submission deadline 30 Oct 2025 | Viewed by 385 | Submission Open
Keywords: multifactorial disorders; genetic factors; epigenetic factors; polymorphisms; gene– gene interactions; gene– miRNA interactions; miRNA; methylation state; genetic susceptibility
(This special issue belongs to the Section Human Genomics and Genetic Diseases)
Progress and Applications of Sequencing Technologies
edited by and Maria Papale
submission deadline 30 Oct 2025 | Viewed by 184 | Submission Open
Keywords: genomics; transcriptomics; epigenomics; metagenomics; bioinformatics; data analysis
(This special issue belongs to the Section Technologies and Resources for Genetics)
Genetic Breeding and Genomics of Vegetables
edited by , Kailiang Bo and Biao Jiang
submission deadline 30 Oct 2025 | Viewed by 137 | Submission Open
Keywords: vegetable breeding; germplasm innovation; functional genomics; molecular breeding; genome editing; genetic mapping; stress resistance; transcriptomics; bioinformatics
(This special issue belongs to the Section Plant Genetics and Genomics)
Genetic, Epigenetic and Environmental Factors in Dental Development and Pathologies: Genes, Interactions and Dental Development
edited by
submission deadline 5 Nov 2025 | 15 articles | Viewed by 48632 | Submission Open
Keywords: dental development; genetics; epigenetics; complex adaptive systems; interactive networks
(This special issue belongs to the Section Human Genomics and Genetic Diseases)
Genetics in Motor Neuron Diseases submission deadline 5 Nov 2025 | Viewed by 335 | Submission Open
Keywords: motor neuron disease; familial amyotrophic lateral sclerosis (fALS); gene therapy; antisense oligonucleotides (ASOs); precision medicine; novel therapeutic approaches
(This special issue belongs to the Section Neurogenomics)
Advances in Gene Therapy
edited by Ryan Butler
submission deadline 10 Nov 2025 | 1 articles | Viewed by 1164 | Submission Open
Keywords: gene therapy; rare diseases; viral vectors; RNA silencing; gene editing; methylation editing
(This special issue belongs to the Section Human Genomics and Genetic Diseases)
Pharmacogenomics and Personalized Treatment
edited by and Lana Ganoci
submission deadline 10 Nov 2025 | 2 articles | Viewed by 1107 | Submission Open
Keywords: pharmacogenomics; personalized treatment; genetic biomarkers; drug metabolism; gene– drug interactions; genetic variation; clinical pharmacogenomics
(This special issue belongs to the Section Pharmacogenetics)
Advances in Pharmacogenomics of Human Diseases
edited by and Alexander Haliassos
submission deadline 10 Nov 2025 | Viewed by 487 | Submission Open
Keywords: pharmacogenomics; precision medicine; genetic variants; disease susceptibility; clinical genetics; individualized treatment; biomarkers
(This special issue belongs to the Section Pharmacogenetics)
Genetics and Genomics of Lung Cancer
edited by Elisa Frullanti
submission deadline 10 Nov 2025 | Viewed by 443 | Submission Open
Keywords: lung cancer; genetic variants; genomics; biomarkers; pharmacogenomics; targeted therapy
(This special issue belongs to the Section Human Genomics and Genetic Diseases)
Genetics and Genomics of Autism Spectrum Disorders submission deadline 15 Nov 2025 | 1 articles | Viewed by 669 | Submission Open
Keywords: autism spectrum disorders; genetics; new techniques for diagnosis
(This special issue belongs to the Section Neurogenomics)
Advances in Genomics and Epigenetics of Hearing Loss
edited by Alessandro Castiglione
submission deadline 15 Nov 2025 | Viewed by 188 | Submission Open
Keywords: genetics; hearing loss; inner ear; epigenetics; auditory system
(This special issue belongs to the Section Human Genomics and Genetic Diseases)
Next-Generation Sequencing in Rare Genetic Diseases submission deadline 15 Nov 2025 | Viewed by 165 | Submission Open
Keywords: rare genetic diseases; next-generation sequencing; bioinformatics; multiomics data; artificial intelligence; gene discovery; single nucleotide variants; structural variants
(This special issue belongs to the Section Human Genomics and Genetic Diseases)
Immunogenetics and Functional Genomics of Insects
edited by and Fei Wang
submission deadline 15 Nov 2025 | Viewed by 112 | Submission Open
Keywords: host– microbe interaction; microbial infection; insect immunity; immune gene evolution; innmue response; crosstalk
(This special issue belongs to the Section Animal Genetics and Genomics)
Genetics of Cancer Immunology
edited by
submission deadline 20 Nov 2025 | 1 articles | Viewed by 1791 | Submission Open
Keywords: tumor– immune interaction; immunotherapy; immune regulation; immune evasion
(This special issue belongs to the Section Human Genomics and Genetic Diseases)
Genetics and Breeding Improvements in Sheep and Goat
edited by
submission deadline 20 Nov 2025 | 1 articles | Viewed by 693 | Submission Open
Keywords: genetics; breeding improvement; genomic selection; molecular markers
(This special issue belongs to the Section Animal Genetics and Genomics)
Genetic Analysis of Hepatitis Virus Infection submission deadline 20 Nov 2025 | Viewed by 229 | Submission Open
Keywords: hepatitis virus; viral genomics; host genetics; immune response; biomarkers; pathogenesis; next-generation sequencing; personalized medicine; gene– environment interactions; antiviral therapy
(This special issue belongs to the Section Viral Genomics)
HTAAD: Unraveling the Molecular and Clinical Complexity of Heritable Thoracic Aortic Disease
edited by , Rossella Fattori, and Yskert von Kodolitsch
submission deadline 20 Nov 2025 | Viewed by 154 | Submission Open
Keywords: syndromic and non-syndromic HTAAD; Loeys– Dietz syndrome; Marfan syndrome; vascular Ehlers– Danlos syndrome; bicuspid aortic valve; genotype– phenotype correlation; next-generation sequencing (NGS) and omics technologies; extracellular matrix; TGF-β signaling pathway and smooth muscle cell contraction genes; iconodiagnostic
(This special issue belongs to the Section Genetic Diagnosis)
Application of Sequencing Technologies in Cancers
edited by Limin Chen
submission deadline 20 Nov 2025 | Viewed by 140 | Submission Open
Keywords: sequencing technologies; single-cell; spatial transcriptomics; cancer
(This special issue belongs to the Section Human Genomics and Genetic Diseases)
Molecular Adaptation and Evolutionary Genetics in Plants
edited by Wei Zhang
submission deadline 24 Nov 2025 | 6 articles | Viewed by 4672 | Submission Open
Keywords: molecular evolution; plastid genome; mitochondrial genome; nuclear genome; gene family
(This special issue belongs to the Section Plant Genetics and Genomics)
Molecular Genetics and Pathogenesis of Motor Neuron Disease
edited by Tadashi Nakagawa
submission deadline 25 Nov 2025 | 1 articles | Viewed by 2291 | Submission Open
Keywords: motor neuron disease; molecular genetics; molecular and cellular analyses; phenotypic characterization; therapeutic development; clinical applications; omic technologies
(This special issue belongs to the Section Neurogenomics)
Advances in Developing Genomics and Computational Approaches submission deadline 25 Nov 2025 | 1 articles | Viewed by 1977 | Submission Open
Keywords: genomics; computational biology; bioinformatics; machine learning; artificial intelligence (AI); next-generation sequencing (NGS); precision medicine; multi-omics integration; CRISPR-based engineering; single-cell genomics; ethical; legal; and social implications (ELSI); translational genomics; biomedical prediction models; network biology
(This special issue belongs to the Section Technologies and Resources for Genetics)
From Genetic Mechanisms Discovery to Patient-Centered Care: The Expanse of Genomics Research
edited by Kathleen D. Valverde and Deb A. Duquette
submission deadline 25 Nov 2025 | 1 articles | Viewed by 1949 | Submission Open
Keywords: Genomic Medicine; Precision Medicine; Functional Genomics; Variant Interpretation; Genetic Mechanisms
(This special issue belongs to the Section Genetic Diagnosis)
15th Anniversary of Genes: Feature Papers in “Neurogenetics and Neurogenomics”
edited by and Micheal Palladino
submission deadline 25 Nov 2025 | 3 articles | Viewed by 1895 | Submission Open
Keywords: genomics; neurological diseases; multi-omics studies; brain development and function; precision medicine; pathogenic mechanisms
(This special issue belongs to the Section Neurogenomics)
AI and Machine Learning in Cancer Genomics
edited by
submission deadline 25 Nov 2025 | 1 articles | Viewed by 1429 | Submission Open
Keywords: genomics; cancer; AI; ML; tools; signatures; biomarkers; oncology
(This special issue belongs to the Section Bioinformatics)
Genetic Diagnosis and Therapeutics of Eye Diseases submission deadline 25 Nov 2025 | 1 articles | Viewed by 493 | Submission Open
Keywords: genetic eye diseases; inherited retinal disorders; ophthalmic genetics; gene therapy; genetic diagnosis; retinitis pigmentosa; leber congenital amaurosis; personalised medicine; ocular therapeutics; genomic medicine; molecular diagnostics; precision ophthalmology
(This special issue belongs to the Section Human Genomics and Genetic Diseases)
Emerging Topics in Population Genetics and Molecular Anthropology
edited by and Dubravka Havaš Auguštin
submission deadline 25 Nov 2025 | Viewed by 305 | Submission Open
Keywords: population genetics; molecular anthropology; archeogenetics; forensic genetics; impact of genetic diversity on human health; evolution; genome; phylogenetics
(This special issue belongs to the Section Population and Evolutionary Genetics and Genomics)
New Developments in Pediatric Clinical Genetics and Metabolic Diseases
edited by Laura L. Konczal and Chen-Han Wilfred Wu
submission deadline 25 Nov 2025 | Viewed by 212 | Submission Open
Keywords: inherited metabolic disease; gene therapy; CRISPR; mRNA; pediatric genetics; rare inherited disease; whole genome sequencing; diagnosis of rare disorders; treatment of rare disorders; newborn screening
(This special issue belongs to the Section Genetic Diagnosis)
Genetic and Genomic Innovations for Developing Resilient Crops
edited by and
submission deadline 25 Nov 2025 | Viewed by 203 | Submission Open
Keywords: crop improvement; abiotic stress; gene function; transcriptomics; gene editing; molecular breeding
(This special issue belongs to the Section Plant Genetics and Genomics)
Diagnosis and Treatment of Inherited Breast Cancer
edited by Maja Prutki and
submission deadline 25 Nov 2025 | Viewed by 126 | Submission Open
Keywords: inherited breast cancer; germline mutations; BRCA1; BRCA2; genetic testing; risk assessment; preventive strategies; targeted therapy; personalized medicine; genetic counseling
(This special issue belongs to the Section Human Genomics and Genetic Diseases)
Genetics of Neurodevelopmental Disorders, Pathogenesis, and Precision Therapies
edited by Andrea L. Gropman
submission deadline 25 Nov 2025 | Viewed by 118 | Submission Open
Keywords: biochemical genetics; brain imaging; fNIRs; metabolism; child neurology; developmental disorders
(This special issue belongs to the Section Neurogenomics)
Genetic Mechanisms of Plant Resistance to Biotic Stress
edited by
submission deadline 25 Nov 2025 | Viewed by 117 | Submission Open
Keywords: plant diseases; biotic stress; resistance genes; genetics; genomics; plant hosts
(This special issue belongs to the Section Plant Genetics and Genomics)
Host Genetics and Pathogens in One Health Context submission deadline 25 Nov 2025 | Viewed by 113 | Submission Open
Keywords: One Health; farm animals; disease resistance; antimicrobial resistance
(This special issue belongs to the Section Animal Genetics and Genomics)
Genetics of Nerve Regeneration submission deadline 25 Nov 2025 | Viewed by 91 | Submission Open
Keywords: nerve regeneration; neurodegeneration; neuroinflammation; metabolism; biomaterials; gene therapy; nerve repair; organoid
(This special issue belongs to the Section Neurogenomics)
The CranioFacial Biology Group at the University of Adelaide Collection: Genetic, Epigenetic and Environmental Factors in Complex Adaptive Systems, Multilayer Complex Interactive Networks, and Multiple Models During Oral Development
edited by and Matthew Brook O'Donnell
submission deadline 5 Dec 2025 | 2 articles | Viewed by 2514 | Submission Open
Keywords: oral development; genetics; epigenetics; complex adaptive systems; multilayer complex interactive networks; multiple models
(This special issue belongs to the Section Human Genomics and Genetic Diseases)
Genetics of Neuromuscular and Metabolic Diseases
edited by Micheal Palladino and
submission deadline 5 Dec 2025 | 1 articles | Viewed by 1092 | Submission Open
Keywords: neurogenetics; metabolism; genetic models; biochemistry; therapy development; rare and ultra-rare genetic diseases
(This special issue belongs to the Section Neurogenomics)
Genes and Pediatrics submission deadline 10 Dec 2025 | 1 articles | Viewed by 1299 | Submission Open
Keywords: pediatric disease; genetic variant; clinical observation; diagnosis; patient care
(This special issue belongs to the Section Human Genomics and Genetic Diseases)
Genetic Biomarkers in Cancer: From Discovery to Clinical Application
edited by
submission deadline 10 Dec 2025 | 1 articles | Viewed by 790 | Submission Open
Keywords: cancer; tumor biology; biomarkers; cancer therapy; targeted therapy
(This special issue belongs to the Section Human Genomics and Genetic Diseases)
Insights into the Genomic and Genetic Basis of Cardiovascular Disease
edited by Marzia de Biasio and
submission deadline 10 Dec 2025 | 1 articles | Viewed by 666 | Submission Open
Keywords: recurrent idiopathic pericarditis and perimyocarditis; spontaneous coronary dissection; sudden idiopathic cardiac death; idiopathic atrial fibrillation; cardio-oncology and cardio toxicity of anti anti-cancer drugs
(This special issue belongs to the Section Human Genomics and Genetic Diseases)
The Genetics of Male Infertility and Clinical Implications
edited by
submission deadline 10 Dec 2025 | Viewed by 381 | Submission Open
Keywords: genetics; male infertility; azoospermia; next generation sequencing; genetic variants
(This special issue belongs to the Section Human Genomics and Genetic Diseases)
Genetics and Genomics of Lung Diseases
edited by Jun Yang
submission deadline 10 Dec 2025 | Viewed by 167 | Submission Open
Keywords: lung diseases  ; transcriptomics  ; epigenetics  ; gene– environment interaction  ; functional genomics  ; multi-omics integration
(This special issue belongs to the Section Human Genomics and Genetic Diseases)
Plant Genetics, Evolution, Cytogenetics and Cytogenomics for Biodiversity Conservation submission deadline 15 Dec 2025 | 2 articles | Viewed by 1980 | Submission Open
Keywords: plant conservation; cytogenetics; cytogenomics; plant evolution; population genetics; genome evolution; chromosomal variation; polyploidy; biodiversity; genomic resources
(This special issue belongs to the Section Plant Genetics and Genomics)
Genetics and Epidemiology of Parasites
edited by
submission deadline 15 Dec 2025 | 1 articles | Viewed by 612 | Submission Open
Keywords: parasite genetics; parasite genomics; WGS; molecular epidemiology; zoonoses; virulence and pathogenesis; transmission dynamics; genetic diversity
(This special issue belongs to the Section Microbial Genetics and Genomics)
Molecular Genetics of Stress Response in Crops
edited by Jie Zhan
submission deadline 15 Dec 2025 | 1 articles | Viewed by 484 | Submission Open
Keywords: crop; abiotic stresses; protein translation; regulation; molecular mechanism; plant hormones
(This special issue belongs to the Section Plant Genetics and Genomics)
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