Genetics and Genomics of Gliomas

Dear Colleagues,

Glioma classification has undergone a substantial revolution over the last couple of decades, deemphasizing traditional light microscopy and emphasizing molecular alterations. This was most recently highlighted by the fifth edition of the World Health Organization classification of central nervous system tumors, in which many tumor types are now defined by specific molecular alterations. However, several issues and questions persist. At what point have we subtyped tumors too much, diminishing clinical utility? Can the healthcare enterprise, including third party payors, continue to cover ever increasing amounts of molecular testing? Why have new therapies targeting specific molecular alterations been so slow to develop, and why are so few of them truly effective? Are there entirely new techniques on the horizon that might completely upend the existing classification schemes such as long-read sequencing technologies, spatially resolved transcriptomics, proteomics or liquid biopsies?

This Special Issue will cover all aspects of glioma genetics and genomics from bench to bedside including mechanisms of oncogenesis, prognostic and predictive biomarkers, and novel therapeutic approaches. In short, this Special Issue will give us insight into what we should expect to see in the sixth edition of the World Health Organization classification of central nervous system tumors.

Dr. Lawrence J. Jennings
Guest Editor

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Keywords:

oncogenesis

glioma

brain

genomics

proteomics

cancer

precision medicine

molecular markers

genetic predisposition

therapeutic targets