Genetic Risks for Pediatric Cancers and Cancer-Related Outcomes

Dear Colleagues,

The advancement of high-throughput next-generation sequencing has enabled the cost-effective generation of large-scale genetic and genomic data in recent years, and has led to many novel discoveries in cancer genetic etiology. However, in the field of cancer germline genetics, there is still a large gap in the efforts and yields of research conducted between pediatric and adult cancers, partly because pediatric cancers are rare diseases and generally encompass various sites (organ/tissues) and histological subtypes, each with a relatively small number of cases that individual investigators may be able to collect. To address this gap, pooled analyses or meta-analyses based on existing data generated by many investigators world-wide are crucial.

In this Special Issue, we call for submissions to a new collection of genetic and genomic studies that will address the monogenic and polygenic risks for pediatric cancers and cancer-related outcomes. Submissions employing GWAS or meta-GWAS analysis to identify common low-penetrance variants for specific pediatric cancer types or across multiple pediatric cancer types, and family-based studies that search for high-penetrance rare variants, are welcome. More than 85% of patients diagnosed with childhood cancer will become long-term survivors. Genetic- or genomics-focused investigations into treatment-related adverse health outcomes (e.g., second cancers and cardiovascular diseases) also fall within the scope of this Special Issue.

Dr. Zhaoming Wang
Guest Editor

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• pediatric/childhood cancer
• genetic association
• rare variant
• common variant
• GWAS
• NGS
• genetic etiology
• heritability
• predisposition
• susceptibility
• polygenic risk score
• survivorship