Urinary Tract Infections: Diagnosis and Management

A special issue of Diagnostics (ISSN 2075-4418). This special issue belongs to the section "Diagnostic Microbiology and Infectious Disease".

Deadline for manuscript submissions: 31 July 2024 | Viewed by 3813

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Guest Editor
School of Public Health, Sackler School of Medicine, Tel Aviv University, Tel Aviv-Yafo, Israel
Interests: clinical utility; urinary tract infections; elderly, internal medicine; laboratory testing
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Special Issue Information

Dear Colleagues,

The purpose of this Special Issue is threefold. First, we will review various methods for urinalysis, including the more recently introduced automated technology. Second, we will discuss the clinical utility and disutility of various findings. Finally, we will discuss indications for testing. Original research articles, reviews, short communications, and interesting images are welcome, as well as either clinical or basic research.

Prof. Dr. Paul Froom
Guest Editor

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Published Papers (2 papers)

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Research

11 pages, 253 KiB  
Article
Evaluating the Performance of FlukeCatcher at Detecting Urogenital Schistosomiasis
by Louis Fok, Berhanu Erko, David Brett-Major, Abebe Animut, M. Jana Broadhurst, Daisy Dai, John Linville, Bruno Levecke, Yohannes Negash and Abraham Degarege
Diagnostics 2024, 14(10), 1037; https://doi.org/10.3390/diagnostics14101037 - 17 May 2024
Viewed by 182
Abstract
Urine filtration microscopy (UFM) lacks sensitivity in detecting low-intensity Schistosoma haematobium infections. In pursuit of a superior alternative, this study evaluated the performance of FlukeCatcher microscopy (FCM) at detecting S. haematobium eggs in human urine samples. Urine samples were collected from 572 school-age [...] Read more.
Urine filtration microscopy (UFM) lacks sensitivity in detecting low-intensity Schistosoma haematobium infections. In pursuit of a superior alternative, this study evaluated the performance of FlukeCatcher microscopy (FCM) at detecting S. haematobium eggs in human urine samples. Urine samples were collected from 572 school-age children in Afar, Ethiopia in July 2023 and examined using UFM and FCM approaches. Using the combined UFM and FCM results as a reference, the sensitivity, negative predictive value, and agreement levels for the two testing methods in detecting S. haematobium eggs in urine samples were calculated. The sensitivity and negative predictive value of detecting S. haematobium eggs in urine samples for FCM was 84% and 97%, respectively, compared to 65% and 93% for UFM. The FCM test results had an agreement of 61% with the UFM results, compared to 90% with the combined results of FCM and UFM. However, the average egg count estimates were lower when using FCM (6.6 eggs per 10 mL) compared to UFM (14.7 eggs per 10 mL) (p < 0.0001). Incorporating FCM into specimen processing could improve the diagnosis of S. haematobium infection but may underperform in characterizing the intensity of infection. Full article
(This article belongs to the Special Issue Urinary Tract Infections: Diagnosis and Management)
11 pages, 1190 KiB  
Article
Atypical Presentation of Bacteremic Urinary Tract Infection in Older Patients: Frequency and Prognostic Impact
by Caroline Laborde, Julien Bador, Arthur Hacquin, Jérémy Barben, Sophie Putot, Patrick Manckoundia and Alain Putot
Diagnostics 2021, 11(3), 523; https://doi.org/10.3390/diagnostics11030523 - 15 Mar 2021
Cited by 5 | Viewed by 2935
Abstract
In older patients, urinary tract infection (UTI) often has an atypical clinical presentation, making its diagnosis difficult. We aimed to describe the clinical presentation in older inpatients with UTI-related bacteremia and to determine the prognostic impact of atypical presentation. This cohort study included [...] Read more.
In older patients, urinary tract infection (UTI) often has an atypical clinical presentation, making its diagnosis difficult. We aimed to describe the clinical presentation in older inpatients with UTI-related bacteremia and to determine the prognostic impact of atypical presentation. This cohort study included all consecutive patients older than 75 years hospitalized in a university hospital in 2019 with a UTI-related gram-negative bacillus (GNB) bacteremia, defined by blood and urine cultures positive for the same GNB, and followed up for 90 days. Patients with typical symptoms of UTI were compared to patients with atypical forms. Among 3865 inpatients over 75 with GNB-positive urine culture over the inclusion period, 105 patients (2.7%) with bacteremic UTI were included (mean age 85.3 ± 5.9, 61.9% female). Among them, UTI symptoms were reported in only 38 patients (36.2%) and 44 patients (41.9%) had no fever on initial management. Initial diagnosis of UTI was made in only 58% of patient. Mortality at 90 days was 23.6%. After adjustment for confounders, hyperthermia (HR = 0.37; IC95 (0.14–0.97)) and early UTI diagnosis (HR = 0.35; IC95 (0.13–0.94)) were associated with lower mortality, while UTI symptoms were not associated with prognosis. In conclusion, only one third of older patients with UTI developing bacteremia had UTI symptoms. However, early UTI diagnosis was associated with better survival. Full article
(This article belongs to the Special Issue Urinary Tract Infections: Diagnosis and Management)
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