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Diagnostics, Volume 14, Issue 10

2024 May-2 - 93 articles

Cover Story: Successful adoption of digital pathology (DP) and AI depends upon the quality of digitised whole-slide images. The ability to automate image quality assessment will be important as more clinical laboratories adopt DP, and is likely to be an important consideration for the reliability of AI tools as these become available for diagnostic practice. In this feasibility study, we investigated the potential for PathProfiler, an automated image quality assessment tool, to be integrated into a prospective workflow in a real-world diagnostic pathology setting. We demonstrated the reliability of the tool in the identification of suboptimal WSI related particularly to biopsy specimens, flagging slides for remedial action such as re-scanning, and without significant impact on laboratory turnaround time. View this paper
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Articles (93)

  • Comment
  • Open Access
2 Citations
2,843 Views
4 Pages

This Letter to the Editor provides additional information regarding the tragic case of a 6-month-old in Italy with respiratory syncytial virus who deteriorated and died unexpectedly from rapid respiratory insufficiency [...]

(This article belongs to the Special Issue Respiratory Diseases: Diagnosis and Management)
  • Review
  • Open Access
4 Citations
2,453 Views
10 Pages

Interpreting Prostate MRI Reports in the Era of Increasing Prostate MRI Utilization: A Urologist’s Perspective

  • Kevin Miszewski,
  • Katarzyna Skrobisz,
  • Laura Miszewska and
  • Marcin Matuszewski

Multi-parametric prostate MRI (mpMRI) is crucial for diagnosing, staging, and assessing treatment response in individuals with prostate cancer. Radiologists, through an accurate and standardized interpretation of mpMRI, stratify patients who may bene...

(This article belongs to the Section Medical Imaging and Theranostics)
  • Article
  • Open Access
5 Citations
3,978 Views
12 Pages

Does Timing of Radiation Therapy Impact Wound Healing in Patients Undergoing Metastatic Spine Surgery?

  • Ranbir Ahluwalia,
  • Hani Chanbour,
  • Tyler Zeoli,
  • Amir M. Abtahi,
  • Byron F. Stephens and
  • Scott L. Zuckerman

Introduction: The impact of radiation on wound healing after metastatic spine surgery remains an active area of research. In patients undergoing metastatic spine surgery, we sought to (1) assess the relationship between preoperative and/or postoperat...

(This article belongs to the Section Medical Imaging and Theranostics)
  • Article
  • Open Access
8 Citations
2,539 Views
11 Pages

Does Elective Admission vs. Emergency Department Presentation Affect Surgical Outcomes in Metastatic Spine Surgery?

  • Tyler Zeoli,
  • Hani Chanbour,
  • Ranbir Ahluwalia,
  • Amir M. Abtahi,
  • Byron F. Stephens and
  • Scott L. Zuckerman

Introduction: Approximately 20% of patients with metastatic spine disease develop symptomatic spinal cord compression, and these patients can present urgently to the emergency department (ED) or, in a more organized fashion, to a clinic. In a cohort...

(This article belongs to the Section Medical Imaging and Theranostics)
  • Review
  • Open Access
9 Citations
8,005 Views
25 Pages

Stroke management employs a variety of diagnostic imaging modalities, image processing and analysis methods, and treatment procedures. This work categorizes methods for stroke imaging, image processing and analysis, and treatment, and provides their...

(This article belongs to the Section Medical Imaging and Theranostics)
  • Review
  • Open Access
3 Citations
5,068 Views
19 Pages

Novel Insights into Postoperative Surveillance in Resected Pancreatic Cystic Neoplasms—A Review

  • Daniel Vasile Balaban,
  • Laura-Ioana Coman,
  • Marina Balaban,
  • Raluca Simona Costache and
  • Mariana Jinga

Pancreatic cystic lesions (PCL) are frequently encountered in clinical practice and some are referred to surgery due to their neoplastic risk or malignant transformation. The management of PCL involves complex decision-making, with postoperative surv...

(This article belongs to the Section Pathology and Molecular Diagnostics)
  • Systematic Review
  • Open Access
1 Citations
2,112 Views
13 Pages

Robotic Stereotactic Body Radiation Therapy for Oligometastatic Liver Metastases: A Systematic Review of the Literature and Evidence Quality Assessment

  • Ilektra Kyrochristou,
  • Ilias Giannakodimos,
  • Maria Tolia,
  • Ioannis Georgakopoulos,
  • Nikolaos Pararas,
  • Francesk Mulita,
  • Nikolaos Machairas and
  • Dimitrios Schizas

Introduction: The role of stereotactic body radiation therapy (SBRT) as a locally effective therapeutic approach for liver oligometastases from tumors of various origin is well established. We investigated the role of robotic SBRT (rSBRT) treatment o...

(This article belongs to the Section Pathology and Molecular Diagnostics)
  • Systematic Review
  • Open Access
12 Citations
4,569 Views
14 Pages

Objective Methods to Assess Aorto-Iliac Calcifications: A Systematic Review

  • Anna Fornasari,
  • Salomé Kuntz,
  • Chiara Martini,
  • Paolo Perini,
  • Elisa Cabrini,
  • Antonio Freyrie,
  • Anne Lejay and
  • Nabil Chakfé

Vascular calcifications in aorto-iliac arteries are emerging as crucial risk factors for cardiovascular diseases (CVDs) with profound clinical implications. This systematic review, following PRISMA guidelines, investigated methodologies for measuring...

(This article belongs to the Special Issue Advances in Cardiovascular and Pulmonary Imaging)
  • Article
  • Open Access
12 Citations
5,200 Views
13 Pages

Background: the aim of the study was to assess microbiological air quality in operating theatres by determining the level of microbiological contamination of the air and critical surfaces using the passive air sampling method and compliance of the op...

(This article belongs to the Special Issue Microbiology Laboratory: Sample Collection and Diagnosis Advances)
  • Article
  • Open Access
3 Citations
2,804 Views
12 Pages

Early-Onset Colorectal Cancer—A Retrospective Study from a Tertiary Referral Hospital in Romania

  • Elena Savu,
  • Valeriu Șurlin,
  • Liviu Vasile,
  • Ileana Octavia Petrescu,
  • Cristina Elena Singer,
  • Nicolae-Daniel Pirici and
  • Stelian Stefanita Mogoanta

Early-onset colorectal cancer emerges as a distinctive clinical and biological entity and is generally defined as the onset of colon or rectal neoplasia before the age of 50. Several reports describe an increasing incidence worldwide of colorectal ca...

(This article belongs to the Section Pathology and Molecular Diagnostics)
  • Article
  • Open Access
9 Citations
6,170 Views
12 Pages

The Value of Contrast-Enhanced Ultrasound (CEUS) in the Evaluation of Central Lung Cancer with Obstructive Atelectasis

  • Ehsan Safai Zadeh,
  • Katharina Paulina Huber,
  • Christian Görg,
  • Helmut Prosch and
  • Hajo Findeisen

Purpose: To assess the diagnostic performance of contrast-enhanced ultrasound (CEUS) alongside contrast-enhanced computed tomography (CECT) in evaluating central lung cancer (CLC). Materials and Methods: From 2006 to 2022, 54 patients with CLC and ob...

(This article belongs to the Special Issue Current Challenges and Perspectives of Ultrasound)
  • Article
  • Open Access
2 Citations
2,439 Views
16 Pages

Assessment of Calcaneal Spongy Bone Magnetic Resonance Characteristics in Women: A Comparison between Measures Obtained at 0.3 T, 1.5 T, and 3.0 T

  • Silvia Capuani,
  • Alessandra Maiuro,
  • Emiliano Giampà,
  • Marco Montuori,
  • Viviana Varrucciu,
  • Gisela E. Hagberg,
  • Vincenzo Vinicola and
  • Sergio Colonna

Background: There is a growing interest in bone tissue MRI and an even greater interest in using low-cost MR scanners. However, the characteristics of bone MRI remain to be fully defined, especially at low field strength. This study aimed to characte...

(This article belongs to the Special Issue Machine-Extractable Knowledge from the Shape of Anatomical Structures 2024)
  • Article
  • Open Access
20 Citations
4,444 Views
15 Pages

A Multichannel CT and Radiomics-Guided CNN-ViT (RadCT-CNNViT) Ensemble Network for Diagnosis of Pulmonary Sarcoidosis

  • Jianwei Qiu,
  • Jhimli Mitra,
  • Soumya Ghose,
  • Camille Dumas,
  • Jun Yang,
  • Brion Sarachan and
  • Marc A. Judson

Pulmonary sarcoidosis is a multisystem granulomatous interstitial lung disease (ILD) with a variable presentation and prognosis. The early accurate detection of pulmonary sarcoidosis may prevent progression to pulmonary fibrosis, a serious and potent...

(This article belongs to the Special Issue Artificial Intelligence in Clinical Decision Support)
  • Article
  • Open Access
7 Citations
2,814 Views
12 Pages

The Role of T2 Mapping in Cardiac Amyloidosis

  • Giulia Grazzini,
  • Silvia Pradella,
  • Rossella Bani,
  • Chiara Fornaciari,
  • Francesco Cappelli,
  • Federico Perfetto,
  • Diletta Cozzi,
  • Simona Giovannelli,
  • Giacomo Sica and
  • Vittorio Miele

Cardiac amyloidosis (CA) is an infiltrative cardiomyopathy divided into two types: light-chain (LA) and transthyretin (ATTR) CA. Cardiac magnetic resonance (CMR) has emerged as an important diagnostic tool in CA. While late gadolinium enhancement (LG...

(This article belongs to the Special Issue Cardiothoracic Imaging: Recent Techniques and Applications in Diagnostics, Second Edition)
  • Article
  • Open Access
14 Citations
3,636 Views
11 Pages

Identifying Autism Gaze Patterns in Five-Second Data Records

  • Pedro Lencastre,
  • Maryam Lotfigolian and
  • Pedro G. Lind

One of the most challenging problems when diagnosing autism spectrum disorder (ASD) is the need for long sets of data. Collecting data during such long periods is challenging, particularly when dealing with children. This challenge motivates the inve...

(This article belongs to the Special Issue Advances in Diagnosis and Management of Neuropsychiatric Disorders)
  • Article
  • Open Access
4 Citations
2,862 Views
12 Pages

Generation and Validation of Normative, Age-Specific Reference Curves for Bone Strain Index in Women

  • Luca Rinaudo,
  • Sofia Cuttone,
  • Carmelo Messina,
  • Veronica Magni,
  • Davide Capra,
  • Luca Maria Sconfienza,
  • Francesco Sardanelli and
  • Fabio Massimo Ulivieri

Bone Strain Index (BSI), based on dual-energy X-ray absorptiometry (DXA), is a densitometric index of bone strength of the femur and lumbar spine. Higher BSI values indicate a higher strain applied to bone, predisposing to higher fracture risk. This...

(This article belongs to the Special Issue Diagnosis and Management of Osteoporosis)
  • Review
  • Open Access
30 Citations
8,581 Views
20 Pages

A Comprehensive Review on Circulating cfRNA in Plasma: Implications for Disease Diagnosis and Beyond

  • Pengqiang Zhong,
  • Lu Bai,
  • Mengzhi Hong,
  • Juan Ouyang,
  • Ruizhi Wang,
  • Xiaoli Zhang and
  • Peisong Chen

Circulating cfRNA in plasma has emerged as a fascinating area of research with potential applications in disease diagnosis, monitoring, and personalized medicine. Circulating RNA sequencing technology allows for the non-invasive collection of importa...

(This article belongs to the Topic Advances in Genetics and Precision Medicine in Human Diseases)
  • Article
  • Open Access
19 Citations
8,143 Views
17 Pages

Epithelial Cell Adhesion Molecule (EpCAM) Expression in Human Tumors: A Comparison with Pan-Cytokeratin and TROP2 in 14,832 Tumors

  • Anne Menz,
  • Nora Lony,
  • Maximilian Lennartz,
  • Sebastian Dwertmann Rico,
  • Ria Schlichter,
  • Simon Kind,
  • Viktor Reiswich,
  • Florian Viehweger,
  • David Dum and
  • Sören Weidemann
  • + 16 authors

EpCAM is expressed in many epithelial tumors and is used for the distinction of malignant mesotheliomas from adenocarcinomas and as a surrogate pan-epithelial marker. A tissue microarray containing 14,832 samples from 120 different tumor categories w...

(This article belongs to the Section Pathology and Molecular Diagnostics)
  • Review
  • Open Access
16 Citations
6,914 Views
21 Pages

PET/CT Imaging of Infectious Diseases: Overview of Novel Radiopharmaceuticals

  • Ferdinando F. Calabria,
  • Giuliana Guadagnino,
  • Andrea Cimini and
  • Mario Leporace

Infectious diseases represent one of the most common causes of hospital admission worldwide. The diagnostic work-up requires a complex clinical approach, including laboratory data, CT and MRI, other imaging tools, and microbiologic cultures. PET/CT w...

(This article belongs to the Section Medical Imaging and Theranostics)
  • Article
  • Open Access
1 Citations
2,647 Views
16 Pages

The Role of QRS Complex and ST-Segment in Major Adverse Cardiovascular Events Prediction in Patients with ST Elevated Myocardial Infarction: A 6-Year Follow-Up Study

  • Srđan Maletin,
  • Milovan Petrović,
  • Anastazija Stojšić-Milosavljević,
  • Tatjana Miljković,
  • Aleksandra Milovančev,
  • Ivan Petrović,
  • Isidora Milosavljević,
  • Ana Balenović and
  • Milenko Čanković

Background: as a relatively high number of ST-segment elevation myocardial infarction (STEMI) patients develop major adverse cardiovascular events (MACE) following percutaneous coronary intervention (PCI), our aim was to determine the significance, a...

(This article belongs to the Topic Cardiovascular Disease in 2023: Coronary Syndrome, Heart Failure and Structural Heart Disease)
  • Article
  • Open Access
8 Citations
5,989 Views
14 Pages

Comparative Evaluation of Chest Ultrasonography and Computed Tomography as Predictors of Malignant Pleural Effusion: A Prospective Study

  • Samah M. Shehata,
  • Yassir Edrees Almalki,
  • Mohammad Abd Alkhalik Basha,
  • Rasha Mohamed Hendy,
  • Eman M. Mahmoud,
  • Marwa Elsayed Abd Elhamed,
  • Sharifa Khalid Alduraibi,
  • Mervat Aboualkheir,
  • Ziyad A. Almushayti and
  • Maha E. Alsadik
  • + 2 authors

Malignant pleural effusion (MPE) is a manifestation of advanced cancer that requires a prompt and accurate diagnosis. Ultrasonography (US) and computed tomography (CT) are valuable imaging techniques for evaluating pleural effusions; however, their r...

(This article belongs to the Special Issue Imaging and Chest Diseases)
  • Article
  • Open Access
3 Citations
3,316 Views
13 Pages

Facial acne is a prevalent dermatological condition regularly observed in the general population. However, it is important to detect acne early as the condition can worsen if not treated. For this purpose, deep-learning-based methods have been propos...

(This article belongs to the Special Issue Advances in Medical Image Processing, Segmentation and Classification)
  • Article
  • Open Access
1 Citations
2,087 Views
14 Pages

SARS-CoV-2 Seroepidemiology and Antibody Levels in Children during BA.5 Predominance Period

  • Filippos Filippatos,
  • Elizabeth-Barbara Tatsi,
  • Maria-Myrto Dourdouna,
  • Emmanouil Zoumakis,
  • Alexandra Margeli,
  • Vasiliki Syriopoulou and
  • Athanasios Michos

This is a SARS-CoV-2 seroepidemiological study in a pediatric population (0–16 years) during the BA.5 Omicron predominance period in the Athens metropolitan area. Serum samples were tested for SARS-CoV-2 nucleocapsid antibodies (Abs-N), represe...

(This article belongs to the Special Issue Editorial Board Members' Collection Series: Molecular Diagnostics of Infectious Diseases)
  • Interesting Images
  • Open Access
7 Citations
2,923 Views
6 Pages

Malposition of Central Venous Catheter into Coronary Sinus throughout the Persistent Left Superior Vena Cava and Other Complications Related to Catheterization

  • Barbara Syska,
  • Anna S. Veer,
  • Patrycja S. Matusik,
  • Jarosław D. Jarczewski,
  • Katarzyna Krzanowska and
  • Tadeusz J. Popiela

This case concentrates on the persistent left superior vena cava (PLSVC), a rare vascular anomaly which contributes to central venous catheter (CVC) misplacement. A 72-year-old woman with renal insufficiency presented to the hospital with recurrent b...

(This article belongs to the Section Pathology and Molecular Diagnostics)
  • Article
  • Open Access
1 Citations
1,855 Views
11 Pages

Evaluating the Performance of FlukeCatcher at Detecting Urogenital Schistosomiasis

  • Louis Fok,
  • Berhanu Erko,
  • David Brett-Major,
  • Abebe Animut,
  • M. Jana Broadhurst,
  • Daisy Dai,
  • John Linville,
  • Bruno Levecke,
  • Yohannes Negash and
  • Abraham Degarege

Urine filtration microscopy (UFM) lacks sensitivity in detecting low-intensity Schistosoma haematobium infections. In pursuit of a superior alternative, this study evaluated the performance of FlukeCatcher microscopy (FCM) at detecting S. haematobium...

(This article belongs to the Section Diagnostic Microbiology and Infectious Disease)
  • Article
  • Open Access
5 Citations
2,007 Views
16 Pages

Predicting Response to Exclusive Combined Radio-Chemotherapy in Naso-Oropharyngeal Cancer: The Role of Texture Analysis

  • Eleonora Bicci,
  • Leonardo Calamandrei,
  • Antonio Di Finizio,
  • Michele Pietragalla,
  • Sebastiano Paolucci,
  • Simone Busoni,
  • Francesco Mungai,
  • Cosimo Nardi,
  • Luigi Bonasera and
  • Vittorio Miele

The aim of this work is to identify MRI texture features able to predict the response to radio-chemotherapy (RT-CHT) in patients with naso-oropharyngeal carcinoma (NPC-OPC) before treatment in order to help clinical decision making. Textural features...

(This article belongs to the Section Medical Imaging and Theranostics)
  • Review
  • Open Access
5 Citations
5,945 Views
21 Pages

MRI Application and Challenges of Hyperpolarized Carbon-13 Pyruvate in Translational and Clinical Cardiovascular Studies: A Literature Review

  • Francesca Frijia,
  • Alessandra Flori,
  • Giulio Giovannetti,
  • Andrea Barison,
  • Luca Menichetti,
  • Maria Filomena Santarelli and
  • Vincenzo Positano

Cardiovascular disease shows, or may even be caused by, changes in metabolism. Hyperpolarized magnetic resonance spectroscopy and imaging is a technique that could assess the role of different aspects of metabolism in heart disease, allowing real-tim...

(This article belongs to the Section Medical Imaging and Theranostics)
  • Review
  • Open Access
84 Citations
8,364 Views
24 Pages

Scoping Review of Experimental and Clinical Evidence and Its Influence on Development of the Suction Ureteral Access Sheath

  • Steffi Kar Kei Yuen,
  • Olivier Traxer,
  • Marcelo Langer Wroclawski,
  • Nariman Gadzhiev,
  • Chu Ann Chai,
  • Ee Jean Lim,
  • Carlo Giulioni,
  • Virgilio De Stefano,
  • Carlotta Nedbal and
  • Vineet Gauhar
  • + 4 authors

The ureteral access sheath (UAS) has been a boon and a bane in flexible ureteroscopy (FURS), with its merits and demerits well established. Its design and dimensions were instrumental in reshaping the way flexible scopes were used and were key adjunc...

(This article belongs to the Special Issue Diagnosis and Prognosis of Urological Diseases)
  • Article
  • Open Access
5 Citations
3,989 Views
13 Pages

Development of an Antigen Capture Lateral Flow Immunoassay for the Detection of Burkholderia pseudomallei

  • Teerapat Nualnoi,
  • Paweena Wongwitwichot,
  • Siriluk Kaewmanee,
  • Pornchanan Chanchay,
  • Nattapong Wongpanti,
  • Tossapol Ueangsuwan,
  • Rattikarn Siangsanor,
  • Wannittaya Chotirouangnapa,
  • Tanatchaporn Saechin and
  • Vannarat Saechan
  • + 3 authors

Early diagnosis is essential for the successful management of Burkholderia pseudomallei infection, but it cannot be achieved by the current gold standard culture technique. Therefore, this study aimed to develop a lateral flow immunoassay (LFIA) targ...

(This article belongs to the Section Point-of-Care Diagnostics and Devices)
  • Article
  • Open Access
3 Citations
4,040 Views
12 Pages

The objective of this study was to investigate the upper incisors (U1), lower incisors (L1), and soft tissue profiles of bimaxillary protrusion (BM) adult patients among skeletal Class I (BM1), II (BM2) and III (BM3). Understanding these characterist...

(This article belongs to the Section Pathology and Molecular Diagnostics)
  • Article
  • Open Access
5 Citations
2,849 Views
13 Pages

Evaluating the Margins of Breast Cancer Tumors by Using Digital Breast Tomosynthesis with Deep Learning: A Preliminary Assessment

  • Wei-Chung Shia,
  • Yu-Hsun Kuo,
  • Fang-Rong Hsu,
  • Joseph Lin,
  • Wen-Pei Wu,
  • Hwa-Koon Wu,
  • Wei-Cheng Yeh and
  • Dar-Ren Chen

Background: The assessment information of tumor margins is extremely important for the success of the breast cancer surgery and whether the patient undergoes a second operation. However, conducting surgical margin assessments is a time-consuming task...

(This article belongs to the Special Issue Advances in Breast Radiology)
  • Systematic Review
  • Open Access
8 Citations
3,502 Views
17 Pages

The Efficacy and Safety of Tandem Transplant Versus Single Stem Cell Transplant for Multiple Myeloma Patients: A Systematic Review and Meta-Analysis

  • Yu-Han Chen,
  • Lindsay Fogel,
  • Andrea Yue-En Sun,
  • Chieh Yang,
  • Rushin Patel,
  • Wei-Cheng Chang,
  • Po-Huang Chen,
  • Hong-Jie Jhou,
  • Yeu-Chin Chen and
  • Cho-Hao Lee
  • + 1 author

While high-dose therapy and autologous stem cell transplant (ASCT) remain integral to the primary treatment of newly diagnosed transplant-elble multiple myeloma (MM) patients, the challenge of disease progression persists. The primary objective of th...

(This article belongs to the Section Clinical Laboratory Medicine)
  • Article
  • Open Access
2 Citations
2,001 Views
11 Pages

Comprehensive Two-Dimensional Pediatric Echocardiographic Nomograms for Coronary Artery Sizes in Caucasian Children and Comparison among Major Nomograms

  • Massimiliano Cantinotti,
  • Marco Scalese,
  • Francesca Valeria Contini,
  • Eliana Franchi,
  • Cecilia Viacava,
  • Giulia Corana,
  • Alessandra Pizzuto,
  • Marchese Pietro,
  • Giuseppe Santoro and
  • Nadia Assanta

Background: Although coronary artery nomograms in children have been published, data on Caucasian children are lacking. The aim of this study is to provide: (i) a full dataset of coronary artery diameters in healthy children and (ii) a comparison amo...

(This article belongs to the Special Issue Cardiothoracic Imaging: Diagnostics and Modern Techniques—2nd Edition)
  • Article
  • Open Access
4 Citations
2,687 Views
16 Pages

Impact of CDK Inhibitors on TBXT Expression in Chordoma Cell Lines Including the First Stable Cell Line of a High-Grade Chordoma

  • Sarah Bette,
  • Luisa Haase,
  • Juliane Nell,
  • Thomas Grieser,
  • Alexandra von Baer,
  • Markus Schultheiss,
  • Ralf Marienfeld,
  • Peter Möller,
  • Thomas F. E. Barth and
  • Kevin Mellert

Chordomas are very rare malignant neoplasms of the bone occurring almost exclusively along the spine. As the tumours are thought to arise from notochordal remnants, the vast majority of chordomas express the TBXT gene, resulting in detectable nuclear...

(This article belongs to the Special Issue Bone Tumours: From Molecular Pathology to Clinical Practice)
  • Communication
  • Open Access
4 Citations
3,223 Views
11 Pages

Development of a Simple Method to Detect the Carbapenemase-Producing Genes blaNDM, blaOXA-48-like, blaIMP, blaKPC, and blaVIM Using a LAMP Method with Lateral Flow DNA Chromatography

  • Kei Mikita,
  • Moe Tajima,
  • Anwarul Haque,
  • Yasuyuki Kato,
  • Satoshi Iwata,
  • Koichi Suzuki,
  • Naoki Hasegawa,
  • Hisakazu Yano and
  • Tetsuya Matsumoto

Infections by carbapenemase-producing Enterobacterales constitute a global public health threat. The rapid and efficient diagnosis of Enterobacterales infection is critical for prompt treatment and infection control, especially in hospital settings....

(This article belongs to the Section Point-of-Care Diagnostics and Devices)
  • Article
  • Open Access
11 Citations
4,468 Views
11 Pages

The Incidence of Thyroid Cancer in Bethesda III Thyroid Nodules: A Retrospective Analysis at a Single Endocrine Surgery Center

  • Iyad Hassan,
  • Lina Hassan,
  • Nahed Balalaa,
  • Mohamad Askar,
  • Hussa Alshehhi and
  • Mohamad Almarzooqi

Background: Fine-needle aspiration cytology (FNAC) is widely used to diagnose and monitor thyroid nodules. The Bethesda System for Reporting Thyroid Cytopathology (TBSRTC) is the standard for interpreting FNAC specimens. The risk of malignancy in Bet...

(This article belongs to the Special Issue Cyto-Histological Correlations in Pathology Diagnosis)
  • Interesting Images
  • Open Access
1 Citations
1,977 Views
4 Pages

TAFRO Syndrome on 18F-FDG-PET/CT: An Appealing Diagnostic Tool

  • Ayoub Jaafari,
  • Nadim Taheri,
  • Sohaïb Mansour,
  • Saïf-Eddine El Bouhali and
  • Rachid Attou

TAFRO syndrome (TS) is a recently recognized and heterogenous systemic disease characterized by a confluence of symptoms: thrombocytopenia (T), anasarca (A), fever (F), reticulin myelofibrosis (R), and organomegaly (O). First described in Japan in 20...

(This article belongs to the Section Medical Imaging and Theranostics)
  • Article
  • Open Access
2,675 Views
16 Pages

Rare Driver Mutations in Advanced, Oncogene-Addicted Non-Small Cell Lung Cancer: A North Italian, Real-World, Registry Experience

  • Kalliopi Andrikou,
  • Paola Ulivi,
  • Elisabetta Petracci,
  • Irene Azzali,
  • Federica Bertolini,
  • Giulia Alberti,
  • Stefania Bettelli,
  • Daniele Calistri,
  • Elisa Chiadini and
  • Angelo Delmonte
  • + 11 authors

The real-world, retrospective, NEROnE registry investigated the impact of next-generation sequencing (NGS) in advanced non-small-cell lung cancer (NSCLC) patients (pts) at three oncology units in the north of Italy between January 2020 and December 2...

(This article belongs to the Special Issue Lung Cancer: Screening, Diagnosis and Management)
  • Article
  • Open Access
5 Citations
4,968 Views
22 Pages

Evaluation of the Immunohistochemical Scoring System of CDX2 Expression as a Prognostic Biomarker in Colon Cancer

  • Andreea-Corina Ilie-Petrov,
  • Daniel-Alin Cristian,
  • Florin Andrei Grama,
  • Andrei Chitul,
  • Angela Blajin,
  • Andrei Popa,
  • Draga-Maria Mandi,
  • Luminița Welt,
  • Marina Alina Bara and
  • Carmen Maria Ardeleanu
  • + 1 author

Encoded by the CDX2 homeobox gene, the CDX2 protein assumes the role of a pivotal transcription factor localized within the nucleus of intestinal epithelial cells, orchestrating the delicate equilibrium of intestinal physiology while intricately guid...

(This article belongs to the Special Issue Diagnosis and Management in Digestive Surgery)
  • Article
  • Open Access
1 Citations
2,333 Views
10 Pages

Normal Values for Echocardiographic Myocardial Work in a Large Pediatric Population

  • Pietro Marchese,
  • Marco Scalese,
  • Nadia Assanta,
  • Eliana Franchi,
  • Cecilia Viacava,
  • Giuseppe Santoro,
  • Giulia Corana,
  • Alessandra Pizzuto,
  • Francesca Valeria Contini and
  • Massimiliano Cantinotti
  • + 1 author

Background: Echocardiographic myocardial work is a new load-independent echocardiographic technique to quantify left ventricle (LV) systolic performance. Our aim was to establish normal values for echocardiographic myocardial work in a large populati...

(This article belongs to the Special Issue Clinical Diagnosis and Management in Cardiology)
  • Article
  • Open Access
4 Citations
2,915 Views
11 Pages

This study investigated compensation in skeletal Class III subjects to compare various severities of abnormal jaws. A retrospective analysis of 137 skeletal Class III cephalograms (63 males and 74 females) was conducted, with cephalometric assessment...

(This article belongs to the Special Issue Advances in the Diagnosis of Oral Diseases)
  • Article
  • Open Access
6 Citations
6,576 Views
11 Pages

The Association between Low Fetal Fraction of Non-Invasive Prenatal Testing and Adverse Pregnancy Outcomes for Placental Compromise

  • Soo-Hyun Kim,
  • You-Mi Hong,
  • Ji-Eun Park,
  • Sung-Shin Shim,
  • Hee-Jin Park,
  • Yeon-Kyung Cho,
  • June-Seek Choi,
  • Joong-Sik Shin,
  • Hyun-Mee Ryu and
  • You-Jung Han
  • + 2 authors

(1) Background: Non-invasive prenatal testing (NIPT) is a screening test for fetal aneuploidy using cell-free fetal DNA. The fetal fragments (FF) of cell-free DNA (cfDNA) are derived from apoptotic trophoblast of the placenta. The level of fetal cfDN...

(This article belongs to the Special Issue Advancements in Maternal–Fetal Medicine)
  • Article
  • Open Access
12 Citations
3,285 Views
12 Pages

Cranial Computer Tomography with Photon Counting and Energy-Integrated Detectors: Objective Comparison in the Same Patients

  • Anna Klempka,
  • Alexander Schröder,
  • Philipp Neumayer,
  • Christoph Groden,
  • Sven Clausen and
  • Svetlana Hetjens

This study provides an objective comparison of cranial computed tomography (CT) imaging quality and radiation dose between photon counting detectors (PCCTs) and energy-integrated detectors (EIDs). We retrospectively analyzed 158 CT scans from 76 pati...

(This article belongs to the Special Issue Advances in the Diagnosis of Nervous System Diseases—2nd Edition)
  • Interesting Images
  • Open Access
1 Citations
2,367 Views
3 Pages

A 24-year-old immunocompetent woman underwent whole-body 18F-FDG PET/CT for the evaluation of MRI-suspicious tuberculous spinal lesions. The PET/CT results showed no pathological uptake in either lung, and there were no pathological changes on CT. Th...

(This article belongs to the Special Issue 18F-FDG PET/CT: Current and Future Clinical Applications)
  • Article
  • Open Access
17 Citations
2,594 Views
18 Pages

The SARS-CoV-2 virus, responsible for COVID-19, often manifests symptoms akin to viral pneumonia, complicating early detection and potentially leading to severe COVID pneumonia and long-term effects. Particularly affecting young individuals, the elde...

(This article belongs to the Section Machine Learning and Artificial Intelligence in Diagnostics)
  • Review
  • Open Access
2,876 Views
9 Pages

Vasa Previa and the Role of Fetal Fibronectin and Cervical Length Surveillance: A Review

  • Antonia F. Oladipo,
  • Kaitlyn Voity,
  • Kimberly Murphy,
  • Manuel Alvarez and
  • Jesus Alvarez-Perez

Vasa previa is a pregnancy complication that occurs when unprotected fetal blood vessels traverse the cervical os, placing the fetus at high risk of exsanguination and fetal death. These fetal vessels may be compromised by fetal movement and compress...

(This article belongs to the Section Pathology and Molecular Diagnostics)
  • Article
  • Open Access
8 Citations
3,356 Views
14 Pages

Breast Delineation in Full-Field Digital Mammography Using the Segment Anything Model

  • Andrés Larroza,
  • Francisco Javier Pérez-Benito,
  • Raquel Tendero,
  • Juan Carlos Perez-Cortes,
  • Marta Román and
  • Rafael Llobet

Breast cancer is a major health concern worldwide. Mammography, a cost-effective and accurate tool, is crucial in combating this issue. However, low contrast, noise, and artifacts can limit the diagnostic capabilities of radiologists. Computer-Aided...

(This article belongs to the Special Issue Advances in Breast Radiology)
  • Interesting Images
  • Open Access
3 Citations
3,631 Views
7 Pages

Late Outcomes of Undiagnosed Unilateral Condylar Hyperplasia and Reoccurrence of Mandibular Asymmetry

  • Kamil Nelke,
  • Wojciech Pawlak,
  • Klaudiusz Łuczak,
  • Maciej Janeczek,
  • Edyta Pasicka,
  • Jan Nienartowicz,
  • Grzegorz Gogolewski and
  • Maciej Dobrzyński

Unilateral condylar hyperplasia (UCH) is a rare cause of asymmetrical mandibular overgrowth because of the presence of an atypical growth in the affected condyle. SPECT (single-photon emission computed tomography) can easily establish the presence of...

(This article belongs to the Collection Interesting Images)
  • Reply
  • Open Access
2 Citations
1,272 Views
2 Pages

Reply to Kawasaki et al. Comment on “Manole et al. Primary Pericardial Synovial Sarcoma: A Case Report and Literature Review. Diagnostics 2022, 12, 158”

  • Simona Manole,
  • Roxana Pintican,
  • Emanuel Palade,
  • Maria Magdalena Duma,
  • Alexandra Dadarlat-Pop,
  • Calin Schiau,
  • Ioana Bene,
  • Raluca Rancea,
  • Diana Miclea and
  • Carolina Solomon
  • + 2 authors

Thank you for your comment; it adds value to the article and highlights the importance of molecular testing [...]

(This article belongs to the Section Pathology and Molecular Diagnostics)
  • Comment
  • Open Access
1,303 Views
4 Pages

With great interest, we read the article by Manole et al [...]

(This article belongs to the Section Pathology and Molecular Diagnostics)

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Diagnostics - ISSN 2075-4418