Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
3.6
3.6
Journals
Diagnostics
Special Issues
Advances in Diagnostic Techniques in Retinal Diseases
share announcement

Advances in Diagnostic Techniques in Retinal Diseases

A special issue of Diagnostics (ISSN 2075-4418). This special issue belongs to the section "Medical Imaging and Theranostics".

Deadline for manuscript submissions: closed (30 November 2023) | Viewed by 821

Special Issue Editors

Dr. Lorenzo Ferro Desideri

E-Mail Website
Guest Editor
Inselspital, University Hospital, Department of Ophthlamology, 3010 Bern, Switzerland
Interests: ocular imaging; medical retina; AI; OCT; OCTA; CSCR; macular degeneration
Dr. Rodrigo Anguita

E-Mail Website
Guest Editor
Department of Ophthalmology, Inselspital, University Hospital of Bern, Freiburgstrasse 18, 3010 Bern, Switzerland
Interests: retinal detachment; vitreoretinal surgery; eye tumours; ocular oncology; ocular trauma; ocular imaging

Special Issue Information

Dear Colleagues,

There have been significant advances in diagnostic techniques for retinal diseases in recent years. Among them, optical coherence tomography (OCT) imaging has played a crucial role for many years in the diagnosis and management of retinal and choroidal diseases, allowing for high-quality, cross-sectional analysis of these anatomical structures. Furthermore, OCT angiography (OCTA) imaging is currently being adopted in everyday clinical routine as a non-invasive, dye-less alternative to fluorescein angiography (FA). Nonetheless, other novel OCT techniques, including wide-field OCT, visible light OCT, high-resolution OCT, intraoperative OCT, and handheld OCT, are currently being investigated. In recent years, artificial intelligence (AI) has shown enormous potential to improve the accuracy and efficiency for the early diagnosis and treatment of retinal diseases, leading to the possibility to improve patients’ outcomes.

Moreover, several advances have been made in the field of ocular oncology, with the improvement of diagnostic techniques and early diagnosis of these eye tumours.

This Special Issue aims to collect papers focusing on the latest developments achieved in the field of ocular imaging, AI, and ocular oncology, highlighting the potential of technological advances to impact the everyday clinical practice.

Dr. Lorenzo Ferro Desideri
Dr. Rodrigo Anguita
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Diagnostics is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • retina
  • retinal imaging
  • OCT
  • OCTA
  • AI
  • eye tumors
  • diagnostic techniques

Published Papers (1 paper)

Order results
Result details
Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:

Research

14 pages, 6301 KiB  
Article
The Fate of RPE Cells Following hESC-RPE Patch Transplantation in Haemorrhagic Wet AMD: Pigmentation, Extension of Pigmentation, Thickness of Transplant, Assessment for Proliferation and Visual Function—A 5 Year-Follow Up
by Lyndon da Cruz, Taha Soomro, Odysseas Georgiadis, Britta Nommiste, Mandeep S. Sagoo and Peter Coffey
Diagnostics 2024, 14(10), 1005; https://doi.org/10.3390/diagnostics14101005 - 13 May 2024
Viewed by 575
Abstract
(1) Background: We reviewed a stem cell-derived therapeutic strategy for advanced neovascular age-related macular degeneration (nAMD) using a human embryonic stem cell-derived retinal pigment epithelium (hESC-RPE) monolayer delivered on a coated, synthetic basement membrane (BM)—the patch—and assessed the presence and distribution of hESC-RPE [...] Read more.
(1) Background: We reviewed a stem cell-derived therapeutic strategy for advanced neovascular age-related macular degeneration (nAMD) using a human embryonic stem cell-derived retinal pigment epithelium (hESC-RPE) monolayer delivered on a coated, synthetic basement membrane (BM)—the patch—and assessed the presence and distribution of hESC-RPE over 5 years following transplantation, as well as functional outcomes. (2) Methods: Two subjects with acute vision loss due to sub-macular haemorrhage in advanced nAMD received the hESC-RPE patch. Systematic immunosuppression was used peri-operatively followed by local depot immunosuppression. The subjects were monitored for five years with observation of RPE patch pigmentation, extension beyond the patch boundary into surrounding retina, thickness of hESC-RPE and synthetic BM and review for migration and proliferation of hESC-RPE. Visual function was also assessed. (3) Results: The two study participants showed clear RPE characteristics of the patch, preservation of some retinal ultrastructure with signs of remodelling, fibrosis and thinning on optical coherence tomography over the 5-year period. For both participants, there was evidence of pigment extension beyond the patch continuing until 12 months post-operatively, which stabilised and was preserved until 5 years post-operatively. Measurement of hESC-RPE and BM thickness over time for both cases were consistent with predefined histological measurements of these two layers. There was no evidence of distant RPE migration or proliferation in either case beyond the monolayer. Sustained visual acuity improvement was apparent for 2 years in both subjects, with one subject maintaining the improvement for 5 years. Both subjects demonstrated initial improvement in fixation and microperimetry compared to baseline, at year 1, although only one maintained this at 4 years post-intervention. (4) Conclusions: hESC-RPE patches show evidence of continued pigmentation, with extension, to cover bare host basement membrane for up to 5 years post-implantation. There is evidence that this represents functional RPE on the patch and at the patch border where host RPE is absent. The measurements for thickness of hESC-RPE and BM suggest persistence of both layers at 5 years. No safety concerns were raised for the hypothetical risk of RPE migration, proliferation or tumour formation. Visual function also showed sustained improvement for 2 years in one subject and 5 years in the other subject. Full article
(This article belongs to the Special Issue Advances in Diagnostic Techniques in Retinal Diseases)
►▼ Show Figures

Figure 1

Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:
 
Displaying articles 1-1
Back to TopTop