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Diagnostics
Special Issues
Diagnosis and Management of Primary Glomerular Disease
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Diagnosis and Management of Primary Glomerular Disease

A special issue of Diagnostics (ISSN 2075-4418). This special issue belongs to the section "Pathology and Molecular Diagnostics".

Deadline for manuscript submissions: closed (28 April 2023) | Viewed by 7869

Special Issue Editor

Dr. Chien-Hung Lin

E-Mail Website
Guest Editor
Division of Pediatric Immunology and Nephrology, Department of Pediatrics, Taipei Veterans General Hospital, Taipei 11221, Taiwan
Interests: acute and chronic kidney disease; early prediction; molecular diagnosis; precision therapy
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Glomerular diseases are often associated with idiopathic etiologies and their clinical presentation can be frequently variable. When nephrotic syndrome is present, it can lead to potential morbidity and resulting clinical outcomes are unfavorable. Glomerular diseases may eventually cause a loss of kidney function and are a major cause of chronic kidney disease (CKD) and end-stage renal disease (ESRD). A kidney biopsy is the most common diagnostic method for glomerular disease, and corticosteroids or immunosuppressants and supportive treatment are the most common methods used to manage nephropathy.

With the development of new diagnostic methods, a more comprehensive understanding of the molecular pathogenesis of different glomerular diseases has been achieved. In addition, personalized treatments for molecular targets have also been revolutionized with higher efficacy and greater effectiveness.

We welcome original articles as well as reviews that focus on new diagnostic approaches and novel  managements for primary glomerular diseases in this Special Issue.

Dr. Chien-Hung Lin
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Diagnostics is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • glomerular disease
  • nephrotic syndrome
  • acute kidney injury
  • chronic kidney disease
  • diagnosis options
  • potential markers
  • management outcomes

Published Papers (2 papers)

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Research

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13 pages, 591 KiB  
Article
Determination of Anti-Phospholipase A2 and Anti-Thrombospondin Type 1 Domain-Containing Protein 7A in Latin Patients with Membranous Nephropathy
by Ligia C. Battaini, Otavio T. Ranzani, Lia J. Marçal, Leila Antonangelo, Lecticia B. Jorge, Cristiane D. Bitencourt, Victoria Woronik, Denise M. A. Malheiros and Luis Yu
Diagnostics 2023, 13(1), 17; https://doi.org/10.3390/diagnostics13010017 - 21 Dec 2022
Cited by 1 | Viewed by 1125
Abstract
Primary membranous nephropathy (MN) is caused by antibodies against podocyte antigens, especially the type M receptor of phospholipase A2 (PLA2R) and thrombospondin type-1 domain containing 7 A (THSD7A). This study’s aim was the determination of anti-PLA2R, anti-THSD7A serum antibodies, and anti-PLA2R renal tissue [...] Read more.
Primary membranous nephropathy (MN) is caused by antibodies against podocyte antigens, especially the type M receptor of phospholipase A2 (PLA2R) and thrombospondin type-1 domain containing 7 A (THSD7A). This study’s aim was the determination of anti-PLA2R, anti-THSD7A serum antibodies, and anti-PLA2R renal tissue staining prevalence in a Latin population with MN, as well as evaluating their role as biomarkers for disease activity. The performance of the two anti-PLA2R serum diagnostic methods—ELISA and indirect immunofluorescence (IFI)—was evaluated for the diagnosis of MN. Fifty-nine patients, including 29 with MN, 18 with lupus membranous nephropathy (LMN) and 12 with focal and segmental glomerulosclerosis (FSGS), were evaluated for serum antibodies. Renal biopsies were also evaluated for the presence of anti-PLA2R staining. Twenty-one patients with MN were followed for 1 year. Patients with LMN and FSGS were negative for both antibodies. All 29 MN patients were negative for anti-THSD7A; 16 MN patients were positive for anti-PLA2R by ELISA and/or IFI, and 3 MN patients were positive for anti-PLA2R only by IFI. Thus, the anti-PLA2R ELISA test demonstrated 45% sensitivity and 97% specificity, while the IFI test showed, respectively, 55% and 100% in our MN patients. Among the 28 MN renal biopsies, 20 presented anti-PLA2R positive staining, corresponding to a 72% sensitivity. Positive correlations were observed between the anti-PLA2R ELISA titer and proteinuria. In conclusion, determination of anti-PLA2R antibodies in the MN Latin population showed similar rates to those reported for other populations. The anti-PLA2R serum levels correlated with MN disease activity. Full article
(This article belongs to the Special Issue Diagnosis and Management of Primary Glomerular Disease)
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Review

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19 pages, 711 KiB  
Review
IgA Nephropathy: Current Understanding and Perspectives on Pathogenesis and Targeted Treatment
by Yating Du, Tingzhu Cheng, Chenxuan Liu, Tingting Zhu, Chuan Guo, Shen Li, Xiangrong Rao and Jinpu Li
Diagnostics 2023, 13(2), 303; https://doi.org/10.3390/diagnostics13020303 - 13 Jan 2023
Cited by 12 | Viewed by 6226
Abstract
Immunoglobulin A nephropathy (IgAN) is the most common primary glomerulonephritis worldwide, with varied clinical and histopathological features between individuals, particularly across races. As an autoimmune disease, IgAN arises from consequences of increased circulating levels of galactose-deficient IgA1 and mesangial deposition of IgA-containing immune [...] Read more.
Immunoglobulin A nephropathy (IgAN) is the most common primary glomerulonephritis worldwide, with varied clinical and histopathological features between individuals, particularly across races. As an autoimmune disease, IgAN arises from consequences of increased circulating levels of galactose-deficient IgA1 and mesangial deposition of IgA-containing immune complexes, which are recognized as key events in the widely accepted “multi-hit” pathogenesis of IgAN. The emerging evidence further provides insights into the role of genes, environment, mucosal immunity and complement system. These developments are paralleled by the increasing availability of diagnostic tools, potential biomarkers and therapeutic agents. In this review, we summarize current evidence and outline novel findings in the prognosis, clinical trials and translational research from the updated perspectives of IgAN pathogenesis. Full article
(This article belongs to the Special Issue Diagnosis and Management of Primary Glomerular Disease)
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