Diet and Physical Activity Management during Cancer

Dear Colleagues,

Lifestyle factors of diet and physical activity are two main factors that are essential for the prevention of diseases associated with aging, such as cardiovascular, neurodegenerative, and oncological disease. Unbalanced diets and a sedentary lifestyle favor adiposity and promote metabolic syndrome, which generates pro-inflammatory conditions that foster cancer onset and progression.

It has recently emerged that non-pharmacological dietary interventions such as caloric restriction and leisurely physical activity have beneficial effects, not only in the prevention of cancer but also in improving and enhancing the effectiveness of anti-tumor therapies. This has been demonstrated in preclinical models and also in human clinical studies.

Caloric restriction and physical activity modulate common signaling pathways, also acting on the release of hormones, cytokines, and metabolites that could directly influence tumor cells as well as the tumor environment and the immune system.

The purpose of this Special Issue is to summarize the recent progress achieved in deciphering the role of diets and physical activities, the underlying signaling pathways that may have a positive impact in preventing tumorigenesis, improving anticancer therapies, and potential pharmacological targets capable of mimicking the effects of caloric restriction and physical activity.

Dr. Salvatore Cortellino
Guest Editor

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• diets and physical activities
• signaling pathways
• preventing tumorigenesis
• anticancer therapies
• potential pharmacological targets
• caloric restriction