Innate Immunity Responds to Virus Infection

Dear Colleagues,

As the first line of host defense against pathogens, the innate immune system utilizes pattern-recognition receptors (PRRs) to detect the invasion of viruses and initiate host antiviral responses such as the production of type I interferons and proinflammatory cytokines. On the other hand, viruses have developed various mechanisms to evade the innate immune system and utilize various mechanisms that are advantageous for viral replication. Thus, understanding the detailed interaction mechanisms between host factors and viruses can provide invaluable information and may shed new light on therapeutic options for the various viral infection-related diseases. This Special Issue will focus on the latest research findings at the molecular level, cellular level and in vivo animal models during the viral infection of various viruses (such as coronaviruses, alphaviruses, flaviviruses, etc.). In addition, this Special Issue is especially interested in long-term chronic infection with multiple viruses.

Dr. Zhenlu Chong
Guest Editor

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• viral infection
• cGAS-STING
• RIG-I
• toll-like receptors
• IFN-I
• IFN-III
• JAK-STAT pathway
• ubiquitination
• cellular and molecular studies
• animal model