Children

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Special Issue Editor

Dr. Kiran Nandalike

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Guest Editor

Division of Pulmonary Medicine, Department of Pediatrics, University of California Davis Health, Sacramento, CA, USA
Interests: obstructive sleep apnea; insomnia; asthma; cystic fibrosis; bronchoscopy

Special Issue Information

Dear Colleagues,

This Special Issue will focus on the diagnosis and treatment of obstructive sleep apnea in children in with underlying pulmonary conditions.

Obstructive sleep apnea (OSA) is a common sleep breathing disorder in children, affecting 2-5% of the general pediatric population. Untreated OSA is linked to adverse neurobehavioral and cardiovascular outcomes and is associated with poor quality of life in children. Several pulmonary conditions are considered risk factors for OSA, including asthma, BPD and restrictive lung disease related to neuromuscular weakness.

For this Special Issue, we are seeking research and review articles focusing on the prevalence, pathophysiology, disease interactions and management of OSA in these situations.

Dr. Kiran Nandalike
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Children is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

obstructive sleep apnea
sleep breathing disorder
sleep disorders
neuromuscular weakness
adverse neurobehaviors
asthma
BPD
restrictive lung disease

Published Papers (2 papers)

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Research

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11 pages, 1539 KiB

Open AccessArticle

Effect of Obesity on the Respiratory Parameters in Children with Obstructive Sleep Apnea Syndrome

by Carolina Caliendo, Rossella Femiano, Giuseppina Rosaria Umano, Stefano Martina, Ludovica Nucci, Letizia Perillo and Vincenzo Grassia

Children 2023, 10(12), 1874; https://doi.org/10.3390/children10121874 - 29 Nov 2023

Viewed by 891

Abstract

The aim of the study was to investigate how obesity can influence sleep respiratory parameters in obstructive sleep apnea syndrome (OSAS) in children. Methods: The study analyzes 56 Caucasian children and adolescents aged 11 ± 2.79 years with a BMI > 5th percentiles and a PSQ value ≥ 0.33. Children were divided into Obesity Group (OG) with BMI ≥ 95th and Control Group (CG) with 5th < BMI > 95th percentile. All selected children underwent PG. Respiratory parameters AHI (Apnea–Hypopnea Index), SaO₂ (Saturation of Oxygen), ODI (Oxygen Desaturation Index), and Nadir (the lowest value of SaO₂ registered during PG) were extracted from the PG. AHI was used to divide the severity of OSAS into four levels: snoring (AHI ≤ 1), mild (AHI > 1 and ≤5), moderate (AHI > 5 and <10), and severe (AHI ≥ 10). Results: The comparison analysis between the OG and CG showed a statistical significance only for ODI (p = 0.02). A statistically significant correlation between BMI and AHI (r = 0.02), SaO₂ (r = 0.01), and Nadir O₂ (r = 0.02) was found. Conclusions: There was no strong correlation between obesity and OSAS, but a positive association was found between BMI and AHI severity. Full article

(This article belongs to the Special Issue Diagnosis and Treatment of Obstructive Sleep Apnea in Children)

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Other

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10 pages, 982 KiB

Open AccessSystematic Review

Is There an Association between Viral Infections and Risk for Pediatric Obstructive Sleep Apnea? A Systematic Review

by Elody Aïem, Clémence Leblais, Laurence Lupi and Alain Doglio

Children 2023, 10(3), 487; https://doi.org/10.3390/children10030487 - 2 Mar 2023

Cited by 2 | Viewed by 1223

Abstract

(1) Background: Obstructive sleep apnea (OSA) affects approximately 1% to 5% of children. To date, the main pathophysiological factor is adenotonsillar tissue hypertrophy. As many respiratory viruses can persist in secondary lymphoepithelial organs after upper airway infection, the objective of this systematic review was to investigate the link between history of viral infections and the risk of pediatric OSA. (2) Methods: Corresponding references were searched electronically (PubMed [MEDLINE], Cochrane Library and Scopus) until 21 November 2022. Prospective or retrospective cohorts, evaluating the children suffering from OSA with history of viral infections and comparing them with children with no history of viral infections written in English, were included. Four independent reviewers selected studies, extracted data, and evaluated the risk of bias using ROBINS-I. (3) Results: Of 1027 potentially eligible articles, four studies (one retrospective, two prospective cohorts and one case-control) were included. (4) Conclusions: Exposure to lower airway infections may precede the diagnosis of pediatric OSA suggesting that respiratory viruses may play a mechanical role in the development of pediatric OSA. Further research is required to improve our understanding of the role of viral infections. Registration: PROSPERO CRD awaiting. Full article

(This article belongs to the Special Issue Diagnosis and Treatment of Obstructive Sleep Apnea in Children)

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