STIM and Orai Communication in Health and Disease

Dear Colleagues,

Accurately tuned intracellular Ca²⁺ signaling is indispensable for the regulation of a plethora of cellular processes occurring over a wide temporal range, including for instance neuronal signaling, proliferation, and gene transcription. The multiple Ca²⁺ signaling pathways are established via a huge toolkit of Ca²⁺-signaling proteins. A single defect of one of these molecular key players can lead to abnormal cytosolic Ca²⁺ levels, which can be responsible for severe disorders in the immune system, heart function, and neurons or even for cancer. A prominent Ca²⁺ signaling pathway in the cell represents the CRAC channel, composed of two molecular key STIM1 players, a Ca²⁺ sensor in the endoplasmic reticulum, and Orai1, a highly Ca²⁺ selective ion channel in the plasma membrane. These two proteins and their isoforms have been known for more than a decade, and a series of milestones have been reached in the understanding of their structure–function relationship, interplay, and co-regulation with modulatory factors as well as their significance in disease.

Herewith, I would like to cordially invite you all to contribute to this Topic Collection on “STIM1 and Orai1 Communication in Health and Disease” in the form of experimental papers on your latest research, up-to-date research articles, and commentaries. This issue of Cells will specifically focus on novel findings in the field of store-operated Ca²⁺ ion channels in both health and disease.

Dr. Isabella Derler
Collection Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the collection website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-anonymized peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cells is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.