Autophagy Contribution to Cancer Therapy Resistance

Dear Colleagues,

Unfortunately, for many types of cancer, therapy resistance is common and accounts for most cases of treatment failure. Therefore, the identification of new targets and resistance mechanisms is urgently needed to improve clinical outcomes. The well-conserved catabolic process, autophagy, has previously been implicated in the initiation, progression, and therapeutic resistance of numerous tumors. This survival mechanism, characterized by the lysosomal degradation of cytoplasmic content and damaged organelles, ensures energy and cellular homeostasis. In addition, especially through its role in metabolism regulation, tumor and microenvironmental autophagy have been increasingly associated with oncogenesis. However, studies to better understand its role and identify through which molecular and cellular mechanisms autophagy regulates response to therapy, especially in vivo, are still necessary.

This Special Issue will investigate, in vitro and in vivo, the contribution of autophagy to cancer resistance and relapse, depending on tumor type and the treatments used, in order to understand whether autophagy modulation could be an interesting strategy to improve therapy efficacy.

Dr. Carine Joffre
Dr. Laura Poillet
Guest Editors

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• autophagy
• cancers
• therapy resistance