Research on Proteomics and Its Applications in Disease

Dear Colleagues,

Proteomics has acquired a pivotal role in the comprehensive understanding of human biology, revealing biochemical processes involved in complex diseases. Over the last ten years, the main output of differential proteomics investigations evolved from long lists of proteins to the generation of new hypotheses and their functional verification. A bottom-up approach is well suited for the basic investigation and clinical diagnosis of human disease and enables a detailed functional characterization of pathogenic biochemical processes. On the other hand, top-down proteomics has been rapidly evolving and attracting new researchers and interest from different areas of biology, especially biomedicine, thanks to its ability to discriminate proteoforms to broaden the knowledge of the human proteome in health and diseases. Moreover, the topic of spatial proteomics has received increasing interest since protein subcellular localization is tightly controlled and intimately linked to the function.

This Special Issue seeks to provide articles on proteomics that focus on human diseases, comprising viral and bacterial infections, thus generating new hypotheses and providing functional verifications. New studies on spatial proteomics are welcome, since the localizations of molecules and their dynamics at the subcellular level are essential for a complete understanding of cell biology.

Dr. Claudia Landi
Guest Editor

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