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Cells publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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The Placental Matrix: Trophoblasts, Decidualization, and Embryo Implantation

edited by

Vinay Shukla

submission deadline 20 May 2026 | 1 articles | Viewed by 1540 | Submission Open

Keywords: trophoblast; decidualization; embryo implantation; uterus; infection; cancer; reproductive immunology; reproductive toxicology; cellular differentiation

(This special issue belongs to the Section Tissues and Organs)

Targeting Tumor Metabolism and Epigenetics: Mechanisms and Therapeutic Strategies

edited by

Jorge Mata-Garrido

Raquel Francés

and Íñigo Casafont

submission deadline 20 May 2026 | Viewed by 311 | Submission Open

Keywords: tumor metabolism; epigenetics; metabolic reprogramming; DNA methylation; histone modification; warburg effect; glycolysis inhibitors; fatty acid synthesis; chromatin remodeling; cancer therapy

(This special issue belongs to the Section Cellular Metabolism)

New Advances in Cancer Cell Biology: Biomarkers and Therapeutic Targets

edited by

Verena Damiani

submission deadline 20 May 2026 | Viewed by 237 | Submission Open

Keywords: cancer; biomarkers; therapeutic targets

(This special issue belongs to the Section Cellular Immunology)

State-of-the-Art Insights into the Cell Microenvironment

edited by

Said M. Afify

submission deadline 20 May 2026 | Viewed by 164 | Submission Open

Keywords: cell microenvironment; stem cells; organoid and 3D culture models

(This special issue belongs to the Section Cell Microenvironment)

Pathology and Therapies in Brain Tumor

edited by Bachuchu Lal

submission deadline 20 May 2026 | Viewed by 98 | Submission Open

Keywords: brain tumor; gliomas; target treatment; pathogenesis; animal models

(This special issue belongs to the Section Cellular Pathology)

Stem Cell Secretome: Therapeutic Potential in Regenerative Medicine

edited by Emanuela Mari

submission deadline 20 May 2026 | Viewed by 79 | Submission Open

Keywords: paracrine factors and tissue regeneration; secretome conditioned by microenvironment or stimuli; extracellularvesicles vs. soluble fraction; formulations and delivery of the therapeutic secretome

(This special issue belongs to the Section Stem Cells)

Regulation of Iron Homeostasis

edited by

Huangen Ding

submission deadline 20 May 2026 | Viewed by 56 | Submission Open

Keywords: iron homeostasis; iron transport; iron storage; iron-containing proteins

Cellular and Molecular Basis of Sjögren’s Syndrome

edited by Muhammad Shahnawaz Soyfoo

submission deadline 20 May 2026 | Viewed by 42 | Submission Open

Keywords: Sjö gren disease; epithelial dysfunction; immune tolerance; autoimmunity

Molecular Pathogenesis of Ovarian Cancer and Therapeutic Strategies

edited by Jayakumar R. Nair

submission deadline 20 May 2026 | Viewed by 40 | Submission Open

Keywords: ovarian cancer; pathogenic mutations; target therapy; genetic heterogeneity

(This special issue belongs to the Section Cellular Pathology)

Non-Coding and Coding RNAs in Targeted Cancer Therapy

edited by

César López-Camarillo

and

Macrina B. Silva-Cázares

submission deadline 25 May 2026 | 4 articles | Viewed by 8207 | Submission Open

Keywords: gene expression; non-coding RNAs; lncRNAs; microRNAs; piwi-associated RNA; circular RNAs; therapeutic targets

(This special issue belongs to the Section Cell and Gene Therapy)

Small Molecular Therapeutics Promoting Neuronal Plasticity, Hippocampal Learning, and Memory

edited by

Avik Roy

submission deadline 25 May 2026 | 2 articles | Viewed by 5251 | Submission Open

Keywords: synaptic transmission; dendritic spines; metabotropic calcium influx; dendritic morphogenesis; small molecular therapeutics promoting neuronal plasticity

(This special issue belongs to the Section Cellular Neuroscience)

Advances in Musculoskeletal Tissue Regeneration Using Mesenchymal Stromal/Stem Cells, Biomaterials, and Signaling Molecules: Second Edition

edited by

Dimitrios Kouroupis

and

Thomas M. Best

submission deadline 25 May 2026 | 2 articles | Viewed by 3785 | Submission Open

Keywords: mesenchymal stromal/stem cells; extracellular vesicles; biomaterials; signalling molecules; microphysiological systems; musculoskeletal regeneration; immunomodulation; cell therapy; tissue engineering

(This special issue belongs to the Section Stem Cells)

Recent Advances in Astrocyte Neuron Communication

edited by

Stefano Ferroni

and

Francesco Formaggio

submission deadline 25 May 2026 | Viewed by 994 | Submission Open

Keywords: astrocytes; calcium signaling; ion channels; gliotransmitters; brain circuits; reactive astrogliosis; astrocyte heterogeneity; astrocyte– neuron networks; synaptic plasticity

(This special issue belongs to the Section Cellular Neuroscience)

Cell Therapy for Retinal Diseases

edited by

Girish Kumar Srivastava

and

Yogeswaran Lokanathan

submission deadline 25 May 2026 | Viewed by 400 | Submission Open

Keywords: retinal diseases; cell therapy; stem cells; retinal regeneration; cell transplantation; gene editing in retinal therapy; tissue engineering; retinal organoids; vision restoration; clinical translation of cell therapy; future directions in retinal regeneration

(This special issue belongs to the Section Tissues and Organs)

Cell Signaling in Neurodegenerative Disease

edited by

Rijwan Uddin Ahammad

, Yasuhiro Funahashi,

Akira Sobue

Xinjian Zhang

and Md-nadim Hossain

submission deadline 25 May 2026 | Viewed by 335 | Submission Open

Keywords: neurodegeneration; cell signaling; biomarkers; synaptic dysfunction; neuroinflammation; protein aggregation; IPSC and animal models; mitochondrial dysfunction; therapeutic targets; translational neuroscience

(This special issue belongs to the Section Cellular Neuroscience)

Basic Mechanisms and Emerging Therapeutic Strategies for Spinal Cord Injury

edited by

Daniel J. Hellenbrand

and Angela R. Filous

submission deadline 25 May 2026 | Viewed by 156 | Submission Open

Keywords: spinal cord injury; neuroinflammation; neural regeneration; axon growth; neurons; glial cells; oligodendrocytes; myelin; astrocytes; microglia

Cellular and Molecular Insights into Female Reproductive Biology

edited by

Mohamed Ali

submission deadline 25 May 2026 | Viewed by 131 | Submission Open

Keywords: female reproductive biology; cellular mechanisms; reproductive aging; microfluidics; fertility preservation; stem cells; uterine endocrinology; infertility; reproductive health; gametogenesis

(This special issue belongs to the Section Reproductive Cells and Development)

Metabolic Regulation of Cell Behavior and Implications for Aging

edited by

Eloy Bejarano

and José Antonio Rodríguez Navarro

submission deadline 25 May 2026 | Viewed by 98 | Submission Open

Keywords: metabolism; cellular aging; senescence; proteostasis; oxidative stress; glycation; autophagy

Resistance of Hematological Malignancies and Solid Tumors to CAR T Cell Therapy

edited by

Ali R. Jazirehi

submission deadline 25 May 2026 | Viewed by 60 | Submission Open

Keywords: solid tumors; hematological malignancies; CAR T cell; immunotherapy; resistance; apoptosis

Brain Function and Structure: Mapping Complexity in Neuronal Cells

edited by

José Antonio Del Río Fernández

submission deadline 25 May 2026 | Viewed by 50 | Submission Open

Keywords: optogenetics; lab-on-chip platforms and brain organoids; neuronal and glial networks; neuromechanobiology; system neuroscience

Human DNA Replication/Repair Factors

edited by

Shuming Zhang

and

Michal Goldberg

submission deadline 25 May 2026 | Viewed by 41 | Submission Open

Keywords: DNA replication; replisome; DNA polymerase; helicase; replication fork; DNA repair; replication stress; DNA damage response; homologous recombination; replication-coupled DNA repair

From Fat to Flame: Targeting Adipose Tissue in Chronic Inflammation and Exploring Therapeutic Strategies

edited by

Francesca Bianchi

Elena Dozio

and

Lucia La Sala

submission deadline 29 May 2026 | Viewed by 243 | Submission Open

Keywords: obesity; inflammasomes; immune system; microbiota

(This special issue belongs to the Section Tissues and Organs)

Advanced Research in Neurogenesis and Neuroinflammation

edited by

Muskan Gupta

submission deadline 30 May 2026 | 2 articles | Viewed by 2077 | Submission Open

Keywords: neurogenesis; neuroinflammation; neurodegeneration; neurodegenerative diseases; cognitive functions

(This special issue belongs to the Section Cellular Neuroscience)

Autophagy in Stress Responses: From Molecular Mechanisms to Disease Relevance

edited by

Katrina F. Cooper

and Kleiton Silva

submission deadline 30 May 2026 | Viewed by 83 | Submission Open

Keywords: autophagy; stress response; proteostasis; mitophagy; neurodegeneration; aging; stress granules; mTOR signaling; selective autophagy; disease models; exercise; muscle disorders

(This special issue belongs to the Section Autophagy)

Therapeutic Targeting of Myeloid Cells in Tumor

edited by Mirko Farina and

Giovanni Micheloni

submission deadline 30 May 2026 | Viewed by 51 | Submission Open

Keywords: myeloid cells; therapeutic targeting; tumor microenvironment; leukemia; myelodysplastic syndromes; tumor development

Genome Editing in Biomedicine

edited by

Fu-Lei Tang

submission deadline 30 May 2026 | Viewed by 18 | Submission Open

Keywords: genome manipulation; CRISPR/Cas systems; base editing and prime editing; cellular models (organoids/stem cells); stem cell editing; animal models; genetically engineered mouse models (GEMMs); translational research; cell therapy; editing efficiency; virus-like particles (VLPs)

(This special issue belongs to the Section Cell and Gene Therapy)

Protein-Protein Interaction in Health and Disease

edited by

Riccardo Sgarra

and

Sara Petrosino

submission deadline 30 May 2026 | Viewed by 17 | Submission Open

Keywords: protein– protein interactions; mass spectrometry; cross-linking; disease mechanisms; structural biology; proteomics; therapeutic targets; protein complexes

(This special issue belongs to the Section Cell Signaling)

Perinatal Brain Injury—from Pathophysiology to Therapy

edited by Cora H.A. Nijboer,

Bobbi Fleiss

and

Ivo Bendix

submission deadline 31 May 2026 | 9 articles | Viewed by 21166 | Submission Open

Keywords: preterm birth; perinatal brain injury; infection; inflammation; hypoxia; ischemia; hyperoxia; malnutrition; regenerative therapies; pharmacological intervention; stem cells

(This special issue belongs to the Section Cellular Neuroscience)

Proteomic Applications in Ageing and Neurodegenerative Conditions

edited by

Thomas Wishart

Rachel A. Kline

and

Dominic Kurian

submission deadline 31 May 2026 | 4 articles | Viewed by 19139 | Submission Open

(This special issue belongs to the Section Cell Methods)

3D Cultures and Organ-on-a-Chip in Cell and Tissue Cultures

edited by

Annunziata Mauro

Barbara Barboni

and

Giovanna Della Porta

submission deadline 31 May 2026 | 6 articles | Viewed by 15351 | Submission Open

Keywords: three-dimensional cell culture; organ-on-a-chip; tissue engineering; regenerative medicine; drug testing; microfluidics; in vitro models; personalized medicine; cellular interaction; disease modeling

(This special issue belongs to the Section Cell Methods)

Intervertebral Disc Degeneration and Regeneration: New Molecular Mechanisms and Therapeutics—Second Edition

edited by

Hideki Sudo

submission deadline 31 May 2026 | 4 articles | Viewed by 12983 | Submission Open

Keywords: spine; intervertebral disc; biomaterial; stem cell; gene therapy

(This special issue belongs to the Section Cellular Pathology)

Stem Cells and Beyond: Innovations in Tissue Repair and Regeneration

edited by Aurora Almadori

submission deadline 31 May 2026 | 5 articles | Viewed by 12198 | Submission Open

Keywords: adipose-derived stem cells; mesenchymal stem cells; induced pluripotent stem cells; stromal vascular fraction; platelet-rich plasma; exosomes; polynucleotides; cytokines; growth factors; extracellular matrix; cell signaling; wound healing; ageing; immune response; inflammation; scarring

(This special issue belongs to the Section Stem Cells)

Immunoregulatory Functions of Mesenchymal Stem Cells (MSCs)

edited by

Joni H. Ylostalo

submission deadline 31 May 2026 | 3 articles | Viewed by 6065 | Submission Open

Keywords: mesenchymal stem cells; MSCs; immunoregulation; immunosuppression

(This special issue belongs to the Section Stem Cells)

Cilia-Based New Discoveries: Ciliogenesis, Function, and Human Diseases

edited by

Lisbeth Birk Møller

submission deadline 31 May 2026 | 2 articles | Viewed by 5600 | Submission Open

Keywords: primary cilium; human disease; cell signaling; mTOR; Hedgehog; WNT; PDGFRalpha

Glial Cells: Physiological and Pathological Perspective

edited by

Qing Richard Lu

submission deadline 31 May 2026 | 4 articles | Viewed by 4186 | Submission Open

Keywords: neurodegeneration; oligodendrocytes; astrocytes; microglia; neuroinflammation; demyelination neuron– glial interactions; homeostasis; glia-targeted therapies

(This special issue belongs to the Section Cellular Neuroscience)

Adipose-Derived Stem Cells for Tissue Regeneration

edited by

Lukas Prantl, MD, PhD, MHBA, FACS

submission deadline 31 May 2026 | 2 articles | Viewed by 3850 | Submission Open

Keywords: adipose stem cells (ASCs); stromal vascular fraction (SVF); cell enriched lipotransfer (CELT and CELT-PLUS); extracellular vesicles (EVs); tissue processing; basic biology; mechanisms of action; regenerative medicine; cell-bases therapies

(This special issue belongs to the Section Tissues and Organs)

Natural Killer (NK) Cells in Immunity: Limitations and Potential

edited by Rehan Mujeeb Faridi

submission deadline 31 May 2026 | 2 articles | Viewed by 3573 | Submission Open

Keywords: natural killer cells; adaptive NK cells; infection

(This special issue belongs to the Section Cellular Immunology)

Emerging Advances in Neurodegeneration: Innovations in Stem Cell and Organoid Research

edited by

Elena Coccia

submission deadline 31 May 2026 | 1 articles | Viewed by 3258 | Submission Open

Keywords: neurodegeneration; stem cells; induced pluripotent stem cells (iPSCs); brain organoids; disease modeling; therapeutic strategies; personalized medicine

(This special issue belongs to the Section Stem Cells)

The Multifaceted Role of Molecular Chaperones in Cancer: Pro-Tumoral or Therapeutic Function

edited by

Alessandra Maria Vitale

and Federica Scalia

submission deadline 31 May 2026 | 1 articles | Viewed by 1804 | Submission Open

Keywords: molecular chaperones; cancer biology; carcinogenesis; tumor progression; diagnostic/prognostic biomarkers; anti-tumor therapeutic strategies; in vitro/in vivo experimental approaches; in silico computational approaches

Non-Coding RNAs as Regulators of Cellular Function and Disease

edited by

Lucia Natarelli

submission deadline 31 May 2026 | 1 articles | Viewed by 1543 | Submission Open

Keywords: non-coding RNAs; gene regulation; disease mechanisms; therapeutic targets; molecular mechanisms

Exploring the Structural and Functional Diversity of Proteins: Foundations of Life and Biological Complexity

edited by Jiabei Lin

submission deadline 31 May 2026 | 1 articles | Viewed by 956 | Submission Open

Keywords: AAA+ protein; RNA-binding protein; protein kinase; PTMs; protein structure; function; and diseases; protein and RNA homeostasis; neurodegeneration; cancer

G Protein-Coupled Receptors and Diseases

edited by

Yongqiang Chen

submission deadline 31 May 2026 | Viewed by 638 | Submission Open

Keywords: G protein-coupled receptor; taste receptor; microbiome; cancer; aging; neurodegenerative disease; cardiovascular disease; pulmonary hypertension; cell survival; cell death; apoptosis; autophagy; necroptosis; ferroptosis; proliferation

Molecular and Cellular Mechanisms of Type 1 Diabetes (T1D)

edited by Robert Sharp and

Itamar Raz

submission deadline 31 May 2026 | Viewed by 420 | Submission Open

Keywords: T1D; autoimmunity; type 1 diabetes; single-nucleotide polymorphisms (SNPs); viral/bacterial pathogens; T-cell biology; inflammation; pancreatic beta cells; immunoregulatory; molecular biology; cellular biology

(This special issue belongs to the Section Cellular Pathology)

Exploring Morphological Changes and Diversity in Cancer

edited by

Mustapha Kandouz

submission deadline 31 May 2026 | Viewed by 352 | Submission Open

Keywords: morphology; heterogeneity; cancer; phenotype; shape

Development and Characterization of Innovative In Vitro Models

edited by Fengyan Deng and Chongbei Zhao

submission deadline 31 May 2026 | 1 articles | Viewed by 239 | Submission Open

Keywords: 3D organoid development; iPSC; iPSC reprogramming; primary cell derivation; cell immortalization; disease model development; stem cell therapy; molecular biology; cell signaling

Role of Lysosomes in Mediating Cancer Drug Resistance

edited by

Petr Mlejnek

submission deadline 31 May 2026 | Viewed by 211 | Submission Open

Keywords: drug resistance; autophagic cell death; lysosomal-mediated cell death; autophagy; apoptosis; lysosomal exocytosis; lysosomal sequestration; tumor microenvironment

(This special issue belongs to the Section Cell Microenvironment)

Cellular and Molecular Basis of Brain Tumor

edited by

Wojciech Czyżewski

, Tomasz S. Mandat, Grzegorz Turek and Radosław Mlak

submission deadline 31 May 2026 | Viewed by 191 | Submission Open

Keywords: brain tumor; glioma; tumor microenvironment; molecular oncology; epigenetics; tumor stem cells; biomarkers; therapeutic resistance; non-coding RNA; translational research

(This special issue belongs to the Section Cellular Pathology)

Circadian Rhythms in Action: Cellular and Molecular Mechanisms Revealed by Model Organisms

edited by

Girish Chandra Melkani

submission deadline 31 May 2026 | Viewed by 178 | Submission Open

Keywords: circadian rhythm; molecular regulation; cellular mechanisms; model organisms; time-restricted feeding; metabolism; aging; neurodegeneration

Sex Differences in Cardiovascular Structure and Function—from Mechanisms to Therapeutics

edited by

Roshanak Rahimian

and

Mitra Esfandiarei

submission deadline 31 May 2026 | Viewed by 178 | Submission Open

Keywords: cardiovascular diseases; sex hormones; sex differences; vascular and cell signaling; therapeutic targets

Brain Insulin Resistance in Neurodegenerative Disorders and Its Treatments

edited by Konrad Talbot

submission deadline 31 May 2026 | Viewed by 174 | Submission Open

Keywords: Alzheimer’ s disease; brain insulin resistance; Down syndrome; incretin receptor agonist; insulin; insulin resistance; multiple system atrophy; neurodegenerative disease; Parkinson’ s disease

(This special issue belongs to the Section Cellular Neuroscience)

Displaying special issue 451-500 on page 10 of 13.

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