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Cells publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Mechanisms of Antimicrobial Treatment in Human Diseases

edited by

Paolo Gaibani

submission deadline 20 Jun 2026 | 1 articles | Viewed by 3137 | Submission Open

Keywords: multidrug resistance; epidemiology; novel antimicrobial resistance traits

(This special issue belongs to the Section Cellular Pathology)

Biomolecular Condensates in Oncology and Immunology

edited by

Andrzej Mackiewicz

Pravin B. Sehgal

and

Mariusz Kaczmarek

submission deadline 20 Jun 2026 | 1 articles | Viewed by 1811 | Submission Open

Keywords: liquid-liquid phase separation (LLPS); biomolecular condensates; pro-oncogenic signaling; innate and adaptive immunity; transcriptional regulation; epigenetic regulation; condensate targeting; antiviral mechanisms; intercellular adhesion; cell migration and metastasis

(This special issue belongs to the Section Cellular Immunology)

Progress of Nanoparticles in the Treatment of Cancers

edited by

Mohammad Asif Sherwani

and Nafees Ahamad

submission deadline 20 Jun 2026 | 1 articles | Viewed by 1608 | Submission Open

Keywords: nanoparticles; cancer treatment; cellular mechanisms; molecular biology; pathophysiology; drug delivery; drug resistance; immunotherapy; tumor microenvironment

(This special issue belongs to the Section Cell Microenvironment)

Beyond Bystanders: The Emerging Roles of Glia in Brain Health and Disease

edited by

Ruqayya Afridi

submission deadline 20 Jun 2026 | 1 articles | Viewed by 1172 | Submission Open

Keywords: astrocytes; microglia; oligodendrocytes; neuroinflammation; neuroimmunology; synaptic plasticity; blood– brain barrier; neuropsychiatric disorders

(This special issue belongs to the Section Cellular Neuroscience)

Molecular Anatomy and Function of Sensory Organs and Sensory Tissues

edited by

Frank Schmitz

submission deadline 20 Jun 2026 | Viewed by 356 | Submission Open

Keywords: sensory organ; sensory tissue; vision; hearing; skin; sensory structures of internal organs

(This special issue belongs to the Section Tissues and Organs)

New Insights into Astrocytes in Health and Disease

edited by

Tao Tao

submission deadline 20 Jun 2026 | Viewed by 174 | Submission Open

Keywords: astrocytes heterogeneity; blood-brain barrier (BBB); synaptic modulation; metabolic support; neuroinflammation; ageing; neurodegenerative disorders; neurodevelopmental disorders; stress response

(This special issue belongs to the Section Cellular Neuroscience)

Metabolic Reprogramming in Organ Fibrosis and Regeneration

edited by Melanie Tran and Dong Yang

submission deadline 20 Jun 2026 | Viewed by 90 | Submission Open

Keywords: metabolic reprogramming; fibrosis; tissue regeneration; cellular metabolism; mitochondrial dysfunction; tissue repair and remodeling

(This special issue belongs to the Section Cellular Metabolism)

Molecular and Cellular Mechanisms of Insulin Secretion

edited by

Haiqiang Dou

submission deadline 20 Jun 2026 | Viewed by 64 | Submission Open

Keywords: insulin secretion; beta-cells; pancreatic islets; diabetes; exocytosis; Ca2+

(This special issue belongs to the Section Cellular Metabolism)

Research on Islet Cell Biology

edited by Mazhar Kanak

submission deadline 20 Jun 2026 | Viewed by 28 | Submission Open

Keywords: islet inflammation; hypoxia in islets; functional assessment of islets ex vivo and in vivo; islet stress and EVs as markers of stress; encapsulation strategies for islet transplantation; hot topics in islet and SC-beta cell transplantation

The Orchestration of Glial Cells in Health and Disease

edited by Keying Zhu

submission deadline 25 Jun 2026 | 1 articles | Viewed by 1599 | Submission Open

Keywords: microglia; oligodendrocytes; astrocytes; myelin; neuroinflammation

Extracellular Vesicles Based Drug Delivery

edited by

Giovanni Camussi

and

Cristina Grange

submission deadline 25 Jun 2026 | Viewed by 439 | Submission Open

Keywords: EV engineering; targeting; therapy; natural carrier; exosomes

Regenerating Poorly Vascularized Tissues

edited by Simone Pacini

submission deadline 25 Jun 2026 | Viewed by 284 | Submission Open

Keywords: regenerative medicine; avascular tissue; angiogenesis; vasculogenesis; cell-based medicinal products; bioengineered materials; cell transplantation

(This special issue belongs to the Section Tissues and Organs)

The Function of Stem Cells in the Biomedical Applications

edited by Rakesh Kumar Srivastava

submission deadline 25 Jun 2026 | Viewed by 118 | Submission Open

Keywords: stem cells; regenerative medicine; cell therapy; differentiation; disease modeling; tissue engineering; drug discovery

Novel Insights in Chronic Epilepsy—from Molecular Mechanisms to Future Therapies

edited by Kjell Heuser and

Cecilie Nome

submission deadline 25 Jun 2026 | Viewed by 104 | Submission Open

Keywords: epilepsy; epileptogenesis; seizure mechanisms; neuroinflammation; glial cells; reactive gliosis; astrocytes; microglia; antiseizure medication

Cutaneous Regeneration and Tissue Engineering: From Hair Follicle Regeneration to Skin Restoration

edited by Soung-Hoon Lee

submission deadline 25 Jun 2026 | Viewed by 100 | Submission Open

Keywords: skin regeneration; hair follicle regeneration; tissue engineering; regenerative biology; biomaterial scaffolds; organoids and 3D skin models; wound healing; acellular matrices; exosome-based therapy; translational dermatology

Systemic Sclerosis: Cellular Mechanisms, Innovative Diagnostics and Advanced Therapeutics

edited by Muhammad Soyfoo

submission deadline 25 Jun 2026 | Viewed by 81 | Submission Open

Keywords: systemic sclerosis; fibrosis; myofibroblasts; immune dysregulation; endothelial dysfunction; extracellular matrix (ECM); autoimmune disease

Inflammation and Atherosclerosis: Emerging Mechanisms, Biomarkers and Therapeutic Opportunities

edited by Victoria McGilligan

submission deadline 25 Jun 2026 | Viewed by 69 | Submission Open

Keywords: atherosclerosis; inflammation; inflammatory biomarkers; anti-inflammatory therapies; plaque vulnerability; diagnostics and prognostics

The Dual Role of Extracellular Vesicles in Neurodegeneration: Disease Biomarkers and Drug Delivery Platforms Within the Matrix Microenvironment

edited by

Elisa Tonoli

and

Elisabetta Verderio Edwards

submission deadline 25 Jun 2026 | Viewed by 59 | Submission Open

Keywords: extracellular vesicles; neurodegenerative diseases; extracellular matrix; biomarkers; therapeutic applications; drug delivery

(This special issue belongs to the Section Intracellular and Plasma Membranes)

Diabetes-Induced Organ Damage: Cellular Mechanisms and Therapeutic Opportunities

edited by

Mohammed S. Razzaque

submission deadline 30 Jun 2026 | 8 articles | Viewed by 40548 | Submission Open

Keywords: diabetes mellitus; vascular lesions; nephropathy; cardiomyopathy; neuropathy; retinopathy; therapeutic opportunities

(This special issue belongs to the Section Tissues and Organs)

New Research on Immunity and Inflammation in Cardiovascular Disease

edited by Pavel Poredoš

submission deadline 30 Jun 2026 | 7 articles | Viewed by 13819 | Submission Open

Keywords: inflammation; atherosclerosis; coronary artery disease; peripheral arterial disease; cerebrovascular disease; venous thromboembolic disease; circulating biomarkers; anti-innflammatory treatment of cardiovascular disease

(This special issue belongs to the Section Cells of the Cardiovascular System)

Exclusive Review Papers in Parkinson's Research

edited by

Wolfgang Jost

and Ronald F. Pfeiffer

submission deadline 30 Jun 2026 | 2 articles | Viewed by 11913 | Submission Open

Keywords: Parkinson’ s disease; alpha-synuclein; substantia nigra; mitochondria; non-motor symptoms; dopamine; levodopa

(This special issue belongs to the Section Cellular Aging)

Role of Calpains in Health and Diseases

edited by

Michel Baudry

and Peter A. Greer

submission deadline 30 Jun 2026 | 6 articles | Viewed by 9104 | Submission Open

Keywords: calpain; physiology; biochemistry; disease; mutation; target; inhibitor

(This special issue belongs to the Section Cellular Pathology)

Emerging Topics in Smooth Muscle Cell Fate and Plasticity in Atherosclerosis

edited by

Mandy Grootaert

and

Julián Albarrán-Juárez

submission deadline 30 Jun 2026 | 5 articles | Viewed by 6624 | Submission Open

Keywords: vascular smooth muscle cells; lineage tracing; fate mapping; VSMC plasticity; (single cell) (spatial) omics; vascular heterogeneity; atherosclerosis

(This special issue belongs to the Section Cellular Pathology)

Pathology and Treatments of Amyotrophic Lateral Sclerosis (ALS)

edited by Laxman Gangwani

submission deadline 30 Jun 2026 | 2 articles | Viewed by 6271 | Submission Open

Keywords: amyotrophic lateral sclerosis (ALS); pathology; molecular mechanisms; treatments; symptom management; biological mechanisms; risk factors; innovative treatments

(This special issue belongs to the Section Cellular Pathology)

Myocardial Ischemia/Reperfusion Injury: Mechanisms and New Directions in Cardioprotection

edited by Sauri Hernandez-Resendiz

submission deadline 30 Jun 2026 | 2 articles | Viewed by 6204 | Submission Open

Keywords: myocardial infarction; heart failure; ischemia/reperfusion injury; no-reflow phenomenon; oxidative stress; cell death; cardiac metabolism; mitochondrial quality control; inflammation; cardioprotection

(This special issue belongs to the Section Tissues and Organs)

Study on Immune Activity of Natural Products

edited by Xiu-Min Li

submission deadline 30 Jun 2026 | 3 articles | Viewed by 3473 | Submission Open

Keywords: natural products; bioactive compounds; immune activity; immunomodulation; inflammation; autoimmune diseases; immunotherapy; therapeutic potential

MicroRNAs: Regulators of Cellular Fate

edited by

Hsiuying Wang

submission deadline 30 Jun 2026 | 2 articles | Viewed by 2291 | Submission Open

Keywords: microRNA targets; microRNA conservation; microRNA pathway; microRNA mimics; microRNA antagonist; disease biomarker

AMPK: From Mechanisms to New Therapies

edited by

Roland Abi Nahed

and

Farah Diab

submission deadline 30 Jun 2026 | 2 articles | Viewed by 1580 | Submission Open

Keywords: metabolism; AMPK; cancer; biosensors; reproduction; metabolic disorders; therapies

The Role of T Cells and Cellular Signalling in Immune Diseases

edited by Daniela Gallo

submission deadline 30 Jun 2026 | 1 articles | Viewed by 1498 | Submission Open

Keywords: T cells; autoimmune disorders; autoimmune endocrine disorders; targeted therapies

(This special issue belongs to the Section Cellular Immunology)

Emerging Topics in Cachexia

edited by Gabriela Salim Ferreira De Castro

submission deadline 30 Jun 2026 | 1 articles | Viewed by 1264 | Submission Open

Keywords: cachexia; skeletal muscle loss; adipose tissue loss; inflammation; sarcopenia; cancer; body composition; biomarkers

Protein and RNA Regulation in Cells

edited by

Delai Huang

and

Denis Mottet

submission deadline 30 Jun 2026 | 1 articles | Viewed by 933 | Submission Open

Keywords: gene expression; post-transcriptional regulation; post-translational modifications; non-coding RNAs; regulatory networks; protein degradation; RNA decay

Understanding Nasal Inflammation: The Interplay of Diagnosis, Endotypes, and Environmental Shifts

edited by Simonetta Masieri and

Carlo Cavaliere

submission deadline 30 Jun 2026 | 1 articles | Viewed by 802 | Submission Open

Keywords: rhinology; allergy; immunology; environment; pollution; microbiome; inflammation; united airway disease; lymphocyte cells; interleukins

(This special issue belongs to the Section Tissues and Organs)

Extracellular Vesicles and Cell Therapies in Regenerative Nephrology and Urology

edited by

Amankeldi Salybekov

and Ciro Tetta

submission deadline 30 Jun 2026 | 1 articles | Viewed by 789 | Submission Open

Keywords: extracellular vesicles (EVs); microRNA (miRNA); acute kidney injury (AKI); chronic kidney disease (CKD); glomerulonephritis; kidney transplantation; fibrosis; mesenchymal stromal cells (MSCs); engineered EVs; single-cell and spatial omics; machine learning and artificial intelligence; ; precision nephrology; GMP manufacturing; regenerative medicine; biomarkers; artificial intelligence (AI)

(This special issue belongs to the Section Cell Microenvironment)

Cellular and Molecular Mechanisms in Gastrointestinal Diseases

edited by

Shakti Ranjan Satapathy

and

Vikas Yadav

submission deadline 30 Jun 2026 | Viewed by 541 | Submission Open

Keywords: gastrointestinal pathophysiology ; epithelial– mesenchymal transition (EMT) ; inflammation and immune regulation ; tumor microenvironment ; cell signaling pathways ; stem cell biology in GI tract ; molecular biomarkers ; organoids and disease modeling ; microbiome– host interactions ; drug discovery

(This special issue belongs to the Section Tissues and Organs)

Retinoic Acid and Retinoid X Receptors - Series II

edited by

Michael Schubert

and

Pierre Germain

submission deadline 30 Jun 2026 | Viewed by 509 | Submission Open

Keywords: nuclear receptor signaling; retinoic acid receptor; retinoid X receptor; pharmacology; structure/function relationships; genomic and non-genomic signaling; post-translational modification; homeostasis and disease; development; origin and evolution

(This special issue belongs to the Section Cell Nuclei: Function, Transport and Receptors)

Kidney and Lung Disorders: The Role of Tubular and Alveolar Epithelia in Health, Disease, Infection, and Organ Crosstalk

edited by Aparna Renigunta and

Poornima Mahavadi

submission deadline 30 Jun 2026 | Viewed by 393 | Submission Open

Keywords: renal tubular disorders; alveolar lung diseases; transport mechanism; intracellular signaling; viral infection; crosstalk; dialysis; ventilation

Cellular and Molecular Mechanisms in Reproductive Biology and Fertility

edited by

Giorgio Maria Baldini

and Antonio Malvasi

submission deadline 30 Jun 2026 | Viewed by 317 | Submission Open

Keywords: gametogenesis; fertilization; fertility; endocrinology; implantation; gametogenesis regulation; embryo– maternal interaction; reproductive signaling; IVF; in vitro fertilization; ovarian stimulation

(This special issue belongs to the Section Reproductive Cells and Development)

Recent Advances in Extracellular-Intracellular Communication and Cancer Therapies

edited by Ana Rita Carlos

submission deadline 30 Jun 2026 | Viewed by 306 | Submission Open

Keywords: extracellular matrix; ECM– cell communication; integrins; cytoskeleton; cancer therapies

Nuclear Pore Complex in Nanomedicine: Third Edition

edited by

Richard W. Wong

submission deadline 30 Jun 2026 | Viewed by 291 | Submission Open

Keywords: intracellular transport; NPC; mitosis; nano; cancer; brain

Crossroad Between Oxidative Stress and DNA Damage and Repair in Stroke

edited by

William James Antonisamy

Zahoor Shah

and Moorthi Ponnusamy

submission deadline 30 Jun 2026 | Viewed by 252 | Submission Open

Keywords: oxidative stress; DNA damage; DNA repair; stroke; ischemic stroke; neuroinflamamtion; intracranial hemorrhagic stroke; neuronal death

(This special issue belongs to the Section Cellular Neuroscience)

The Cross-Talk Between Obesity and Metabolism

edited by

Hong Shi

submission deadline 30 Jun 2026 | Viewed by 243 | Submission Open

Keywords: obesity; metabolic disorders; insulin resistance; adipose tissue; inflammation; glucose metabolism; lipid metabolism; cardiovascular disease; type 2 diabetes; therapeutic targets

The Role of PPARs in Disease - Volume IV

edited by

Kay-Dietrich Wagner

and

Nicole Wagner

submission deadline 30 Jun 2026 | Viewed by 210 | Submission Open

Keywords: PPAR; immune function; liver; adipose tissue; cardiovascular system; muscle; brain; neurological disease; psychiatric diseases; cancer; transcriptional regulation; ligands; agonists/antagonists

(This special issue belongs to the Section Cells of the Cardiovascular System)

Neuromuscular Disorders: Advances in Cellular and Molecular Understanding, Emerging Therapies, and Outcome Measures

edited by

Ivo Bozovic

and

Bogdan Bjelica

submission deadline 30 Jun 2026 | Viewed by 201 | Submission Open

Keywords: neuromuscular disorders; pathophysiology; biomarkers; treatment; impairment and disability measures; outcome measures

(This special issue belongs to the Section Tissues and Organs)

Hematopoietic Cell Lines as Models for Leukemia and Lymphoma

edited by Stefan Nagel

submission deadline 30 Jun 2026 | Viewed by 201 | Submission Open

Keywords: hematopoiesis; leukemia; lymphoma; transcription factor; homeobox genes

Cellular and Molecular Mechanisms of Hepatobiliary Diseases

edited by

Stefan Hoehme

and

Jan G. Hengstler

submission deadline 30 Jun 2026 | Viewed by 173 | Submission Open

Keywords: hepatobiliary diseases; bile metabolism; hepatobiliary models; artificial intelligence; cholestatic diseases; systems medicine; spatio-temporal liver models

(This special issue belongs to the Section Tissues and Organs)

Extracellular Vesicles in Neurodegenerative Diseases: From Biomarker Discovery to Precision Therapeutics

edited by Mangesh Dattu Hade

submission deadline 30 Jun 2026 | Viewed by 171 | Submission Open

Keywords: neurodegenerative diseases; extracellular vesicles; Alzheimer's disease; Parkinson's disease; multiple sclerosis; blood– brain barrier; neuroinflammation; biomarker discovery; EV-based therapeutics; precision medicine

(This special issue belongs to the Section Cellular Aging)

Thoracic Tumors: Decoding Cellular Heterogeneity, Tumor Microenvironment Crosstalk, and Therapeutic Vulnerabilities

edited by

Vesna Ceriman Krstic

and Dragana Jovanovic

submission deadline 30 Jun 2026 | Viewed by 162 | Submission Open

Keywords: NSCLC; SCLC; mesothelioma; thymoma; thymic carcinoma; immunotherapy; molecular therapy; chemotherapy

(This special issue belongs to the Section Cell Microenvironment)

Mitochondrial Dynamics and Remodelling

edited by Edmund Carvalho

submission deadline 30 Jun 2026 | Viewed by 144 | Submission Open

Keywords: mitochondrial dynamics; fission; fusion; mitophagy; cristae remodeling; bioenergetics; ER– mitochondria contacts; immune reprogramming; signaling pathways; therapeutic targeting

Cellular Signalling Pathways in the Endocrine Pancreas and Diabetes

edited by

Catharina Alam

submission deadline 30 Jun 2026 | Viewed by 138 | Submission Open

Keywords: diabetes; cell signalling; molecular mechanisms; cell stress; endocrine pancreas; β -cells

(This special issue belongs to the Section Cell Signaling)

Nuclear Organization and Nucleocytoplasmic Transport in Neuronal Development and Disease: Mechanisms and Therapeutic Opportunities

edited by

Masood Sepehrimanesh

submission deadline 30 Jun 2026 | Viewed by 137 | Submission Open

Keywords: nuclear organization; nucleocytoplasmic transport; neuronal development; neurodegeneration; nuclear pore complex (NPC); nuclear lamina; RNA trafficking; chromatin regulation; therapeutic targeting; neurodevelopmental disorders

(This special issue belongs to the Section Cellular Neuroscience)

Displaying special issue 451-500 on page 10 of 14.

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