Special Issues

Cells publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Molecular Pathogenesis and Therapeutic Breakthroughs in Cutaneous Malignancies: From Melanoma to Lymphoma
edited by
submission deadline 15 Mar 2026 | Viewed by 35 | Submission Open
Keywords: skin cancer; melanoma; Merkel cell carcinoma; skin lymphoma; squamous cell carcinoma; Mycosis fungoides; adnexal tumors; Sebaceous carcinoma; cutaneous soft tissue tumors
Primary and Continued Cell Cultures
edited by
submission deadline 20 Mar 2026 | 5 articles | Viewed by 41723 | Submission Open
Keywords: primary normal cells; primary tumor cells; patient-derived cells; CRC (conditionally reprogrammed cells); organoids; circulating tumor cells; human diseases; toxicity; cancer models; drug discovery
(This special issue belongs to the Section Cell Methods)
Organoids as an Experimental Tool
edited by , and Anjali A. J. Roeth
submission deadline 20 Mar 2026 | 10 articles | Viewed by 27375 | Submission Open
Keywords: organoid culture models; primary cell and cancer spheroid models; organotypic models; organoid research for animal replacement (3R); chip-based methods; general 3D cell culture protocols; in silico approaches; microinjection apical-out organoids; organoid manipulation techniques; organoid intelligence; organoids in diagnostics; imaging in organoids
(This special issue belongs to the Section Tissues and Organs)
The Role of Cellular Senescence in Health, Disease, and Aging
edited by
submission deadline 20 Mar 2026 | 8 articles | Viewed by 23237 | Submission Open
Keywords: apoptosis; cancer; cell cycle; DNA damage; metabolic diseases; oxidative stress; senolysis; senescence; therapeutic approach
(This special issue belongs to the Section Cellular Aging)
New Advances and Perspectives in Nanotechnology for the Treatment of Cancer Cells submission deadline 20 Mar 2026 | 8 articles | Viewed by 20180 | Submission Open
Keywords: nanotechnology; immunotherapeutics; cancer biotherapeutics; proliferation; regulating factors; cell culture; biomedical application; nutraceuticals; cancer treatment
(This special issue belongs to the Section Cell Methods)
Highlights in Red Blood Cell Research submission deadline 20 Mar 2026 | 3 articles | Viewed by 19991 | Submission Open
Keywords: red blood cells; anemia; transfusion; erythropoiesis; signaling
Insight into Cardiomyopathy
edited by Sobuj Mia
submission deadline 20 Mar 2026 | 1 articles | Viewed by 16775 | Submission Open
Keywords: heart failure; ventricular dysfunction; hypertrophic cardiomyopathy; dilated cardiomyopathy; cardiac fibrosis; cardiac hypertrophy; biomarkers
(This special issue belongs to the Section Cells of the Cardiovascular System)
Advances and Breakthroughs in Stem Cell Research submission deadline 20 Mar 2026 | 2 articles | Viewed by 8063 | Submission Open
Keywords: stem cell; induced pluripotent stem cell; iPSC; hematopoietic stem cell
(This special issue belongs to the Section Stem Cells)
New Concepts Relating Mesenchymal Tumors Based on Genetics and Epigenetics
edited by
submission deadline 20 Mar 2026 | 4 articles | Viewed by 7338 | Submission Open
Keywords: mesenchymal tumors; soft tissue; sarcoma; genetics; epigenetics
(This special issue belongs to the Section Cell Microenvironment)
Targeting Tumor Microenvironments for Enhanced Cancer Immunotherapy
edited by
submission deadline 20 Mar 2026 | 1 articles | Viewed by 1876 | Submission Open
Keywords: tumor microenvironment; cancer immunotherapy; immune modulation; immunosuppressive mechanisms; combination therapies
(This special issue belongs to the Section Cell Microenvironment)
Human Immunodeficiency Virus/Simian Immunodeficiency Virus and Host Interactions
edited by and Susanta Pahari
submission deadline 20 Mar 2026 | 1 articles | Viewed by 1529 | Submission Open
Keywords: HIV/SIV/SHIV infection; rhesus macaques; host immunity; chronic inflammation; mucosal immunity; immune evasion; therapeutic intervention; immune checkpoints; microbiota; substance use
(This special issue belongs to the Section Cellular Immunology)
Protein Misfolding and Aggregation: From Molecular Mechanisms to Human Diseases
edited by Xinrui Gui and Jinjun Wu
submission deadline 20 Mar 2026 | 1 articles | Viewed by 1379 | Submission Open
Keywords: protein aggregation; amyloid fibrils; protein quality control; neurodegenerative diseases
(This special issue belongs to the Section Cellular Biophysics)
Targeting Cellular Microenvironment in Aging and Disease
edited by and Egor Dzyubenko
submission deadline 20 Mar 2026 | 1 articles | Viewed by 1279 | Submission Open
Keywords: proteoglycans; glycans; glycoproteins; matricellular proteins; integrins; matrix metalloproteinases; extracellular vesicles; EV release; exosomes; extracellular scaffold; ECM remodeling; fibrosis; ECM gene therapy; ECM pharmacology; synthetic ECM
(This special issue belongs to the Section Cellular Aging)
Cell Biology: The State of the Art and Perspectives in Japan 2025
edited by
submission deadline 20 Mar 2026 | Viewed by 558 | Submission Open
Keywords: cell biology; physiology; molecular biology
Cancer Cell Signaling, Autophagy and Tumorigenesis
edited by Debanjan Bhattacharya
submission deadline 20 Mar 2026 | Viewed by 188 | Submission Open
Keywords: cancer cell signaling; autophagy; tumorigenesis; PI3K/AKT/mTOR pathway; Ras/Raf/MEK/ERK (MAPK) pathway
Chronic Obstructive Pulmonary Disease (COPD): From Molecular and Cellular Mechanisms to Therapeutic Opportunities
edited by , Bradley W. Richmond and
submission deadline 20 Mar 2026 | Viewed by 126 | Submission Open
Keywords: chronic obstructive pulmonary disease (COPD); small airway disease; vascular remodeling; emphysema
(This special issue belongs to the Section Cellular Immunology)
Cell and Molecular Mechanisms of Cytogenesis submission deadline 20 Mar 2026 | Viewed by 84 | Submission Open
Keywords: cytogenesis; central nervous system; neurogenesis; gliogenesis; neuroplasticity; signaling pathways; cell proliferation; differentiation; CNS homeostasis; neuropsychiatric and neurodegenerative disorders
Novel Insight into Endothelial Cells in Vascular Disease
edited by
submission deadline 20 Mar 2026 | Viewed by 58 | Submission Open
Keywords: endothelial cells; vascular diseases; vascular signaling
Cellular and Molecular Mechanisms of Neurotoxicity
edited by , , Tiziana Cotrufo and
submission deadline 20 Mar 2026 | Submission Open
Keywords: neurotoxicity; neurodegeneration; neuronal cell death; neurodegenerative disorders; nerve regeneration; heavy metals; air pollution; endogenous neurotoxins; oxidative stress; glutamate
Lipid Homeostasis: Mechanisms, Regulation, and Implications for Health and Disease
edited by and Museer Ahmad Lone
submission deadline 25 Mar 2026 | 2 articles | Viewed by 1158 | Submission Open
Keywords: lipid metabolism; lipid synthesis and degradation; triglyceride storage; fatty acid oxidation; cholesterol homeostasis; adipogenesis; lipid droplets; lipid signaling pathways; lipid transport proteins; phospholipid balance; sphingolipid metabolism; sterol regulatory element-binding proteins (SREBPs); AMP-activated protein kinase (AMPK); peroxisome proliferator-activated receptors (PPARs); insulin signaling and lipid storage; endoplasmic reticulum stress and lipids; lipoprotein metabolism; non-alcoholic fatty liver disease (NAFLD); lipidomics; autophagy and lipid recycling; lysosomal lipid degradation; lipid-binding proteins; oxidized lipids; lipid imbalance and disease; energy homeostasis and lipid storage; lipid transport vesicles; membrane lipid composition; lipid peroxidation; lipid-related genetic disorders; nutrient sensing and lipid regulation
(This special issue belongs to the Section Cellular Biophysics)
The Silent Regulators: Non-Coding RNAs in Cell Function and Disease submission deadline 25 Mar 2026 | 1 articles | Viewed by 1086 | Submission Open
Keywords: non-coding RNAs; microRNAs; long non-coding RNAs (lncRNAs); regulatory RNAs; RNA interference; epigenetic regulation; RNA editing; cellular signaling; disease biomarkers; RNA therapeutics
(This special issue belongs to the Section Cell and Gene Therapy)
Gene Editing Therapies for Hereditary Diseases submission deadline 25 Mar 2026 | Viewed by 223 | Submission Open
Keywords: gene therapy; base editing; prime editing; genome editing; hereditary diseases
(This special issue belongs to the Section Cell and Gene Therapy)
Ischemic Heart Disease: From Cellular Level to Clinical Approaches submission deadline 25 Mar 2026 | Viewed by 115 | Submission Open
Keywords: ischemic heart disease; myocardial ischemia; reperfusion injury; oxidative stress; mitochondrial dysfunction; cardiomyocyte death; endothelial dysfunction; inflammation; fibrosis; epigenetics; non-coding RNAs; immunometabolism; single-cell transcriptomics; angiogenesis; ischemic preconditioning; nanomedicine; molecular cardiology; targeted therapy
Cell and Molecular Mechanisms of Bacterial Meningitis submission deadline 25 Mar 2026 | Viewed by 71 | Submission Open
Keywords: bacterial meningitis; innate immunity; inflammation; immune response; central nervous system; neuron; microglia; astrocytes; granulocytes; blood– brain barrier
Mitochondria: Multifaceted Regulators of Cell Death
edited by Rasa Banienė and Sonata Trumbeckaite
submission deadline 25 Mar 2026 | Viewed by 64 | Submission Open
Keywords: mitochondria; cell death; multifaceted regulators; reactive oxygen species (ROS); cell metabolism; mitochondrial transfer
From Signals to Shape: Molecular Control of Cellular Plasticity Through Epigenetic, Transcriptomic, and Immune Mechanisms submission deadline 25 Mar 2026 | Viewed by 53 | Submission Open
Keywords: cellular plasticity; epigenetics; transcriptomics; mechanotransduction; immune signaling; cell fate regulation; RNA methylation; biomaterials interaction; molecular cytology; cell adaptation
Breaking the Balance: Cellular Stress, Proteostasis, Aggregates and Neurodegeneration
edited by
submission deadline 25 Mar 2026 | Viewed by 52 | Submission Open
Keywords: proteostasis; cellular stress; protein aggregation; neurodegeneration; autophagy; unfolded protein response; oxidative stress; aging; molecular chaperones; protein quality control
Cancer Stem Cells in Triple-Negative Breast Cancer submission deadline 25 Mar 2026 | Viewed by 50 | Submission Open
Keywords: cancer stem cells; TNBC; signal pathways; epithelial– mesenchymal transition; tumor microenvironment; targeted therapy; biomarkers
Molecular Mechanisms of Trophoblast Differentiation
edited by Milica Jovanović Krivokuća and
submission deadline 25 Mar 2026 | Viewed by 49 | Submission Open
Keywords: trophoblast differentiation; cytotrophoblast; syncytiotrophoblast; extravillous trophoblast; trophoblast stem cells; molecular mechanisms; signaling pathways; epigenetic regulation
Neuroimaging of Cerebrovascular Diseases
edited by Dragan Stojanov
submission deadline 30 Mar 2026 | Viewed by 129 | Submission Open
Keywords: neuroimaging; cerebrovascular diseases; stroke; intracerebral hemorrhage; SAHA neurysms; AVM; small vessels diseases; CT; MRI; advance MRI techniques; DSA; AI
Nanoparticle-Mediated Immunotherapy: Reshaping the Tumor Microenvironment for Enhanced Cancer Treatment
edited by
submission deadline 30 Mar 2026 | Viewed by 82 | Submission Open
Keywords: tumor microenvironment; drug delivery; nanoparticle
(This special issue belongs to the Section Cell Methods)
Novel Insights into Molecular and Cellular Mechanisms Underlying Chronic Pain submission deadline 30 Mar 2026 | Viewed by 79 | Submission Open
Keywords: pain; pain management; sexual dimorphism; neurons; non-neuronal factors
(This special issue belongs to the Section Cellular Pathology)
Cellular and Molecular Mechanisms of Cardiomyopathy submission deadline 30 Mar 2026 | Viewed by 77 | Submission Open
Keywords: genetic cardiomyopathies; acquired cardiomyopathies; cardiac arrhythmias; disease mechanisms; disease cause; pathogenesis
(This special issue belongs to the Section Tissues and Organs)
Novel Insights into Cancer Immune Responsiveness submission deadline 30 Mar 2026 | Viewed by 66 | Submission Open
Keywords: cancers; tumors; immune cells; tumor immunology; cancer immunology; onco-immunology; immunotherapies; resistance; immunotherapy resistance; immune checkpoint; CAR; antibody; cancer vaccines
Mechanisms of miRNA Metabolism and Extracellular Transport submission deadline 30 Mar 2026 | Viewed by 44 | Submission Open
Keywords: miRNA metabolism; miRNA transport; miRNA exchange; miRNA storage; mRNA biogenesis; extracellular vesicles and miRNA; non-EV miRNA export; miRNA binding proteins; miRNA sponge and inhibitors; miRNA biomarkers
Impact of Chronic Substance Exposure on Hematopoiesis and Immunity
edited by and
submission deadline 30 Mar 2026 | Viewed by 29 | Submission Open
Keywords: cellular immunology; hematopoietic stem and progenitor cells; differentiation; myeloid cells; monocytes; neutrophils; macrophages
Flow Cytometry in Immunology Research
edited by and Ekaterina Kopitman
submission deadline 31 Mar 2026 | 2 articles | Viewed by 10271 | Submission Open
Keywords: multi-parametric analysis; full-spectrum flow cytometry; imaging flow cytometry; immuno-phenotyping; immune synapse; cytokines; activation markers; cancer immunology; host-pathogen interactions; functional immune assays
(This special issue belongs to the Section Cell Methods)
Organoids and Models from Stem Cells
edited by Tiziana A. L. Brevini and
submission deadline 31 Mar 2026 | 3 articles | Viewed by 4852 | Submission Open
Keywords: cellular microenvironment; 3D culture; organoid
(This special issue belongs to the Section Stem Cells)
Axonal Transport: Mechanisms, Disorders, and Therapeutic Approaches
edited by Yuxiang Xie and Jingqi Yan
submission deadline 31 Mar 2026 | 1 articles | Viewed by 3445 | Submission Open
Keywords: axonal transport; motor proteins; autophagy– lysosome pathway; neurodegenerative diseases; therapeutic strategies
(This special issue belongs to the Section Cells of the Nervous System)
Kidney Injury Biomarkers: From Early Detection to Transition to Chronic Kidney Disease submission deadline 31 Mar 2026 | 1 articles | Viewed by 1923 | Submission Open
Keywords: acute kidney injury; acute kidney disease; chronic kidney disease; circulating biomarkers; urinary biomarkers; multiple biomarker panel; diagnosis; prediction; management
(This special issue belongs to the Section Tissues and Organs)
Drosophila as a Model for Understanding Human Disease
edited by Zhe Han
submission deadline 31 Mar 2026 | 1 articles | Viewed by 1607 | Submission Open
Keywords: Drosophila melanogaster; human disease models; genetic and molecular mechanisms; neurodegenerative diseases; cardiovascular diseases; cancer biology; metabolic disorders; high-throughput screening; precision medicine; translational research
(This special issue belongs to the Section Cellular Pathology)
Advances in Reproductive Biology: Cellular and Molecular Mechanisms
edited by and Clara González-Marín
submission deadline 31 Mar 2026 | 2 articles | Viewed by 1349 | Submission Open
Keywords: gametogenesis; fertilization; embryo implantation; reproductive genetics; epigenetics in reproduction; hormonal signaling; stem cells and reproduction; assisted reproductive technologies (ARTs); molecular fertility regulation; reproductive health innovations
(This special issue belongs to the Section Reproductive Cells and Development)
Mechanisms of Modulation of Sensory Plasticity in the Cerebral Cortex
edited by
submission deadline 31 Mar 2026 | 1 articles | Viewed by 1125 | Submission Open
Keywords: synaptic plasticity; synapses; LTP; LTD; ionotropic and metabotropic receptors
(This special issue belongs to the Section Cells of the Nervous System)
mRNA Vaccines and Therapeutics in Melanoma: From Mechanisms to Cellular Impact submission deadline 31 Mar 2026 | 2 articles | Viewed by 913 | Submission Open
Keywords: mRNA vaccines; melanoma; tumor immunology; mRNA vaccine designs; delivery systems
(This special issue belongs to the Section Cellular Pathology)
Molecular Insights into Vascular Physiology and Pathology
edited by Suravi Majumder
submission deadline 31 Mar 2026 | Viewed by 473 | Submission Open
Keywords: vascular physiology; vascular pathology; endothelial cells; vascular smooth muscle cells; vascular inflammation; vascular signaling; vascular aging; vascular remodeling; atherosclerosis; cardiovascular diseases; biomarkers; novel therapeutic approaches
(This special issue belongs to the Section Cellular Pathology)
Cellular and Molecular Insights into Allergies and Allergic Diseases
edited by
submission deadline 31 Mar 2026 | Viewed by 269 | Submission Open
Keywords: allergy; immune regulation; mast cells; Th2 responses; epithelial barrier; IgE; inflammation; cellular signaling; molecular mechanisms
(This special issue belongs to the Section Cellular Immunology)
Mechanisms and Dynamics in Cellular Adhesion in Development and Disease
edited by
submission deadline 31 Mar 2026 | Viewed by 213 | Submission Open
Keywords: actin; integrin; cell adhesion; signalling; mechanotransduction
Current Research on Immunotherapy for Glioblastoma
edited by Markella Zannikou
submission deadline 31 Mar 2026 | Viewed by 203 | Submission Open
Keywords: GBM; tumor microenvironment; cancer vaccines; TIL (tumor-infiltrating lymphocytes) therapy; combination therapy; BiTEs; immune checkpoint therapy; CAR T-cell therapy; peptide/dendritic vaccines; tumor-associated antigens; oncolytic virotherapy
(This special issue belongs to the Section Cellular Immunology)
Ubiquitin Ligases: Key Regulators in Cellular Homeostasis and Disease
edited by Praveen Koganti and
submission deadline 31 Mar 2026 | Viewed by 165 | Submission Open
Keywords: ubiquitin ligases; protein ubiquitination; cellular homeostasis; proteasome pathway
Therapeutic Targeting of MicroRNAs in Human Cancer
edited by
submission deadline 31 Mar 2026 | Viewed by 146 | Submission Open
Keywords: microRNAs; nanoparticle platforms; spatial miRNomics; combination therapeutic strategies
(This special issue belongs to the Section Cell and Gene Therapy)
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