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Cells publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Molecular and Cellular Mechanisms of Type 1 Diabetes (T1D)

edited by Robert Sharp and

Itamar Raz

submission deadline 31 May 2026 | Viewed by 436 | Submission Open

Keywords: T1D; autoimmunity; type 1 diabetes; single-nucleotide polymorphisms (SNPs); viral/bacterial pathogens; T-cell biology; inflammation; pancreatic beta cells; immunoregulatory; molecular biology; cellular biology

(This special issue belongs to the Section Cellular Pathology)

Exploring Morphological Changes and Diversity in Cancer

edited by

Mustapha Kandouz

submission deadline 31 May 2026 | Viewed by 362 | Submission Open

Keywords: morphology; heterogeneity; cancer; phenotype; shape

Circadian Rhythms in Action: Cellular and Molecular Mechanisms Revealed by Model Organisms

edited by

Girish Chandra Melkani

submission deadline 31 May 2026 | Viewed by 230 | Submission Open

Keywords: circadian rhythm; molecular regulation; cellular mechanisms; model organisms; time-restricted feeding; metabolism; aging; neurodegeneration

Role of Lysosomes in Mediating Cancer Drug Resistance

edited by

Petr Mlejnek

submission deadline 31 May 2026 | Viewed by 220 | Submission Open

Keywords: drug resistance; autophagic cell death; lysosomal-mediated cell death; autophagy; apoptosis; lysosomal exocytosis; lysosomal sequestration; tumor microenvironment

(This special issue belongs to the Section Cell Microenvironment)

Cellular and Molecular Basis of Brain Tumor

edited by

Wojciech Czyżewski

, Tomasz S. Mandat, Grzegorz Turek and Radosław Mlak

submission deadline 31 May 2026 | 1 articles | Viewed by 214 | Submission Open

Keywords: brain tumor; glioma; tumor microenvironment; molecular oncology; epigenetics; tumor stem cells; biomarkers; therapeutic resistance; non-coding RNA; translational research

(This special issue belongs to the Section Cellular Pathology)

Molecular Mechanisms of Drug Delivery in Ophthalmology

edited by Alekha K. Dash and Surabhi Shukla

submission deadline 31 May 2026 | Viewed by 188 | Submission Open

Keywords: drug delivery; ophthalmology; nanocarriers; ocular barriers; molecular transport; targeted therapy; ocular gene delivery

(This special issue belongs to the Section Tissues and Organs)

Brain Insulin Resistance in Neurodegenerative Disorders and Its Treatments

edited by Konrad Talbot

submission deadline 31 May 2026 | Viewed by 186 | Submission Open

Keywords: Alzheimer’ s disease; brain insulin resistance; Down syndrome; incretin receptor agonist; insulin; insulin resistance; multiple system atrophy; neurodegenerative disease; Parkinson’ s disease

(This special issue belongs to the Section Cellular Neuroscience)

Inflammatory Signaling and Vascular Dysfunction in Atherosclerosis

edited by

Qianman Peng

and Jianzhong Shen

submission deadline 31 May 2026 | Viewed by 166 | Submission Open

Keywords: inflammation in atherosclerosis; atherothrombosis; cell signaling

Emerging Cell Therapies and Regenerative Approaches in Pulmonary Medicine

edited by Renata Kelly Da Palma

submission deadline 31 May 2026 | Viewed by 161 | Submission Open

Keywords: cell therapy; lung diseases; tissue regeneration

(This special issue belongs to the Section Tissues and Organs)

Extracellular Vesicles in Reproductive Communication: From Gametogenesis to Implantation

edited by

Nima Azari-Dolatabad

and Osvaldo Bogado Pascottini

submission deadline 31 May 2026 | Viewed by 141 | Submission Open

Keywords: extracellular vesicles; reproductive biology; gametogenesis; oocyte maturation; embryo-maternal communication; implantation; reproductive disorders; epigenetic regulation; EV Cargo; intercellular signaling

Cellular and Molecular Mechanisms of Heart Development

edited by Jun K. Takeuchi

submission deadline 31 May 2026 | Viewed by 140 | Submission Open

Keywords: heart development; cardiovascular; epigenetics; cell fate; differentiation; cardiac growth; cardiac morphogenesis; heart regeneration; cardiac organoid

Regulatory Mechanisms of Vascular Smooth Muscle Cells and Immune Cells in Vascular Disease Progression

edited by

Kunzhe Dong

and

Liming Yu

submission deadline 31 May 2026 | Viewed by 137 | Submission Open

Keywords: vascular smooth muscle cells; immune cells; inflammation; vascular disease; atherosclerosis; aneurysm; cellular crosstalk; phenotypic transition

(This special issue belongs to the Section Cells of the Cardiovascular System)

Immunotherapy-Induced Cardiotoxicity: Unraveling the Immune Landscape of Myocarditis

edited by

Pan Ma

submission deadline 31 May 2026 | Viewed by 132 | Submission Open

Keywords: immunotherapy; immune checkpoints; adoptive cell therapy; cardiac adverse events; cardiac inflammation; immune checkpoint inhibitor associated myocarditis; cardiac immune landscape; innate immune response; adaptive immune response; myeloid cells; macrophages; antigen presentation & phagocytosis; T cells; T cell clonality; cytokines; chemokines; chemotaxis; immune crosstalk; immune– stromal crosstalk; multi-omics

Mitochondria Beyond Energy: Signaling, Immunity, and Cell Fate

edited by

Martha E Diaz-Hernandez

submission deadline 31 May 2026 | Viewed by 132 | Submission Open

Keywords: mitochondria; stem cells; cell fate; organogenesis; immunometabolism

Cancer and Vessels: Insights at the Cellular and Molecular Levels

edited by Francesco Pezzella and Tom Donnem

submission deadline 31 May 2026 | Viewed by 131 | Submission Open

Keywords: angiogenesis; vessel co-option; tumor microenvironment; tumor blood vessels; tumor vasculature; metastasis

(This special issue belongs to the Section Cellular Pathology)

New Advances in Cardiac and Vascular Physiology

edited by Robert M. Lust

submission deadline 31 May 2026 | Viewed by 126 | Submission Open

Keywords: environmental exposure; immune responses; remodeling; receptors; ischemia; pre-conditioning; post-conditioning; heart failure

(This special issue belongs to the Section Tissues and Organs)

Skeletal Muscle Aging and Regeneration: Mitochondrial Health, Molecular Signaling, and Therapeutic Interventions

edited by

Stephen E. Alway

submission deadline 31 May 2026 | Viewed by 124 | Submission Open

Keywords: aging; skeletal muscle; regeneration; satellite cells; muscle stem cells; muscle wasting; mitochondria; fibro-adipogenic progenitor cells; repair

Cellular and Molecular Pathways in Immune Tolerance and Autoimmune Regulation

edited by

Md Jahangir Alam

submission deadline 31 May 2026 | Viewed by 102 | Submission Open

Keywords: immune tolerance; autoimmune regulation; immune homeostasis; regulatory T cells; regulatory B cells; cytokine networks; molecular mechanisms; therapeutic strategies

(This special issue belongs to the Section Cellular Immunology)

B Cells in Action: Interaction Dynamics and Functional Decisions

edited by Michael L. Atchison and

Sulagna Sanyal

submission deadline 31 May 2026 | Viewed by 101 | Submission Open

Keywords: B cell development and differentiation; adaptive immunity; germinal center B cell; class-switch recombination; immunosuppression; cytokines; inflammation; epigenetic regulation; metabolic reprogramming; immune response

(This special issue belongs to the Section Cellular Immunology)

Molecular Mechanisms and Therapeutic Strategies for Skeletal Muscle Disorders

edited by

Valentina Di Felice

submission deadline 31 May 2026 | Viewed by 96 | Submission Open

Keywords: skeletal muscle; muscular disorders; myokines; muscle regeneration; muscle atrophy; inflammation; stress response; myoblast

DNA Damage and Repair in Targeted Cancer Therapy

edited by Mohd Saleem Dar, Sajad Ahmad Bhat and

Mohsin Maqbool

submission deadline 31 May 2026 | Viewed by 96 | Submission Open

Keywords: cancer cells; DNA damage and repair mechanism; genome organization; BER; NER; MMR; HR; and NHEJ; targeted therapy; inhibitors/PROATCS; drug resistance; drug toxicity; biomarkers; personalized medicine

Epigenetic and Cellular Regulation in Hematologic Disorders

edited by

Halina Leung

submission deadline 31 May 2026 | Viewed by 90 | Submission Open

Keywords: epigenetics; hematologic disorders; leukemia; myelodysplastic syndrome; thrombosis; thrombocytopenia; bleeding

Advances in Ion Channel Biology: From Molecular Mechanisms to Therapeutic Targets

edited by Shridhar Sanghvi,

Yang Zheng

and

Md Shahidul Islam

submission deadline 31 May 2026 | Viewed by 89 | Submission Open

Keywords: ion channels; electrophysiology; cryo-electron microscopy; channelopathy; membrane protein; gating mechanism; structural biology

Cellular Mechanisms and Therapeutic Potentials of Neurodevelopmental Defects

edited by

and

submission deadline 31 May 2026 | Viewed by 87 | Submission Open

Keywords: neurodevelopmental disorders; neuronal connectivity; precocious therapies; synaptic plasticity; neurogenesis; glial function

(This special issue belongs to the Section Cellular Neuroscience)

Cellular Responses to Heavy Metals: From Intestinal Uptake to Disease

edited by

Aleksandar Cirovic

, Ana V. Ćirović,

Alessandra Pacini

and

Jacopo Junio Valerio Branca

submission deadline 31 May 2026 | Viewed by 81 | Submission Open

Keywords: cadmium (Cd) bioavailability; heavy metal intestinal uptake; heavy metal-induced cardiotoxicity; heavy metal-induced neurotoxicity; heavy metal-induced osteotoxicity; heavy metals and malignancies

Endometrial Cancer: From Molecular Mechanisms to Therapeutic Approaches

edited by Tomaž Büdefeld and

Jure Knez

submission deadline 31 May 2026 | Viewed by 71 | Submission Open

Keywords: endometrial cancer; genetic mutation; epigenetics; cell signaling; TIME; metastasis; biomarker; therapy; drug delivery; risk factor

Decoding Heart Failure: From Mechanisms to Treatment

edited by

Filippos Triposkiadis

and Dirk L. Brutsaert

submission deadline 31 May 2026 | Viewed by 60 | Submission Open

Keywords: heart failure; pathological process; molecular mechanisms; cellular mechanisms; genetic mechanisms; therapeutic target

Stem Cell-Based Strategies for Cardiac Tissue Engineering and Regeneration

edited by Munira Xaymardan and

Nona Farbehi

submission deadline 31 May 2026 | Viewed by 50 | Submission Open

Keywords: cardiac tissue engineering; stem cells; cardiomyocytes; cardiac organoids; engineered heart tissues; biomaterials; scaffolds; gene therapy; RNA reprogramming; cardiac fibrosis; cardiac regeneration; myocardial repair; translational studies

(This special issue belongs to the Section Stem Cells)

Advancements in Research on Metabolic Syndrome

edited by Gautam Kumar Pandey

submission deadline 31 May 2026 | Viewed by 43 | Submission Open

Keywords: metabolic syndrome; multi-omics; insulin resistance; cell signaling in metabolic disease

Molecular Bases Underlying Early Embryonic Development in Mammals

edited by

Rebeca González Fernández

, Julio Ávila Marrero and Angela Palumbo

submission deadline 31 May 2026 | Viewed by 43 | Submission Open

Keywords: embryonic development; early embryogenesis; gene expression; miRNA profile; reproductive physiology; cell signalling; embryo quality; developmental competence; in vitro embryo culture

(This special issue belongs to the Section Reproductive Cells and Development)

Modeling Lung Regeneration and Injury Responses Using Organoids and Engineered Niches

edited by Tristan Frum

submission deadline 31 May 2026 | Viewed by 41 | Submission Open

Keywords: lung biology; regeneration; stem cells; intra- and extracellular signaling; cell techniques; organoids; bioengineering

(This special issue belongs to the Section Tissues and Organs)

Cellular Metabolism and Immune Regulation in Cancer Progression and Metastasis

edited by Xu Jing

submission deadline 31 May 2026 | Viewed by 30 | Submission Open

Keywords: cellular metabolism; tumor immunology; cancer progression; metastasis; immunometabolism; metabolic reprogramming; tumor microenvironment; immune evasion; cancer therapy; metabolic biomarkers

(This special issue belongs to the Section Cellular Metabolism)

Human Pluripotent Stem Cells and Organoids: Current Trends and Future Perspectives

edited by

Eléanor Luce

and

Anne Dubart-Kupperschmitt

submission deadline 1 Jun 2026 | 1 articles | Viewed by 913 | Submission Open

Keywords: human pluripotent stem cells; organoids; disease modeling; regenerative medicine; genome editing; single-cell omics; tissue engineering; drug discovery; precision medicine

(This special issue belongs to the Section Stem Cells)

Molecular Mechanisms of Fibrosis in Chronic Liver Diseases

edited by

Ahmad Salhab

, Regina Golan-Gerstl and Ihab Ansari

submission deadline 1 Jun 2026 | Viewed by 210 | Submission Open

Keywords: liver fibrosis; MASH; immune checkpoints; epigenetic regulation; hepatic stellate cells (HSCs); antifibrotic therapy; molecular mechanisms; inflammation; ROS

Mechanisms, Biomarkers, and Therapeutics of Neurodegeneration

edited by

Xiao Bin

submission deadline 1 Jun 2026 | Viewed by 26 | Submission Open

Keywords: neurodegeneration; biomarkers; mechanistic studies; protein aggregation; protein degradation; neuroinflammation; targeted therapies; genetics; precision medicine

(This special issue belongs to the Section Cellular Neuroscience)

Macrophages in Cancer: Immunosuppression, Immunoregulation, and Immunotherapy

edited by

Abdullah Saeed

submission deadline 5 Jun 2026 | 3 articles | Viewed by 12256 | Submission Open

Keywords: macrophage; immunosuppression; immunoregulation; immunotherapy; tumor immune microenvironment

(This special issue belongs to the Section Cellular Immunology)

Novel Insights into Molecular Mechanisms and Therapy of Myeloma

edited by

Yusuke Furukawa

and

Jian Wu

submission deadline 10 Jun 2026 | 7 articles | Viewed by 18800 | Submission Open

Keywords: multiple myeloma; CAR-T therapy; relapse; methylation; drug resistance; treatment strategy; molecular mechanism; novel target; biomarker

(This special issue belongs to the Section Cellular Pathology)

Advances in Pulmonary Fibrosis

edited by Sergio Piñeiro Hermida

submission deadline 10 Jun 2026 | 1 articles | Viewed by 1359 | Submission Open

Keywords: pulmonary fibrosis; animal models; biomarkers; experimental therapeutics

(This special issue belongs to the Section Cellular Pathology)

Molecular Mechanisms of Cardiac Repair and Regeneration

edited by Mahesh Thirunavukkarasu

submission deadline 10 Jun 2026 | Viewed by 119 | Submission Open

Keywords: cardiac repair and regeneration; cardiomyocyte; cardiac fibrosis; signaling pathways; immune regulation; extracellular vesicles; stem cell therapies; epigenetics; biomarkers

(This special issue belongs to the Section Cells of the Cardiovascular System)

The Metabolic Edge: How Cancer Cells Adapt, Survive, and Resist Therapy

edited by

Frank Schnütgen

submission deadline 10 Jun 2026 | Viewed by 99 | Submission Open

Keywords: cancer metabolism; metabolic rewiring; therapy resistance; metabolic plasticity; nutrient uptake; mitochondrial remodeling; tumor microenvironment; metabolic vulnerabilities

(This special issue belongs to the Section Cellular Metabolism)

Lipid Mediators in Cardiometabolic Regulation and Disease

edited by Adeniyi Michael Adebesin

submission deadline 10 Jun 2026 | Viewed by 53 | Submission Open

Keywords: lipid mediators; lipoprotein; fatty acid metabolites; cellular membranes; cardiometabolic regulation; cellular metabolism; adipogenesis; signaling pathways; receptors; lipid transport proteins

(This special issue belongs to the Section Cellular Metabolism)

The Role of Oxidative Stress in Cardiovascular Diseases—2nd Edition

edited by

Liya Yin

and

Chuanxi Cai

submission deadline 15 Jun 2026 | 1 articles | Viewed by 3881 | Submission Open

Keywords: oxidative stress; antioxidants; apoptosis; atherosclerosis; blood vessel; heart failure; hypertension; inflammation; mitochondria; microcirculation; reactive oxygen species

(This special issue belongs to the Section Cells of the Cardiovascular System)

Cellular Origin of Glioma: From Triggers to Treatments

edited by Katherine Karakoula

submission deadline 15 Jun 2026 | Viewed by 383 | Submission Open

Keywords: glioblastoma; brain tumour; tumour heterogeneity; targeted therapy; glioma stem cells

Novel Insights into Developing Therapeutic Strategies for Neurological Disorders

edited by

Hui Jin Shin

, Joanna A. Korecka and

Yu-Han Huang

submission deadline 15 Jun 2026 | Viewed by 227 | Submission Open

Keywords: neurological disorders; RNA therapeutics; gene therapy; antisense oligonucleotides; gene editing; cell therapy; precision medicine; neurodegenerative diseases; neurodevelopmental disorders; neurogenetic disorders

Regulation of Hormone Secretion from Islets in Health and Disease

edited by

Md Shahidul Islam

submission deadline 15 Jun 2026 | Viewed by 217 | Submission Open

Keywords: islet hormone secretion; paracrine signaling; autocrine regulation; intra-islet communication; islet cell plasticity; transdifferentiation; multi-hormonal dysregulation; circadian regulation; single-cell omics; islet inflammation and immune crosstalk

Genomics and Cellular Mechanisms in Ovarian Cancer

edited by Hao Huang

submission deadline 15 Jun 2026 | Viewed by 161 | Submission Open

Keywords: ovarian cancer; tumor heterogeneity; genomics and epigenomics; therapy resistance; tumor microenvironment

(This special issue belongs to the Section Tissues and Organs)

Bone and Soft Tissue Tumors: Molecular Mechanisms and Emerging Therapeutics

edited by

Marcel Trautmann

submission deadline 15 Jun 2026 | Viewed by 133 | Submission Open

Keywords: sarcoma; bone and soft tissue tumors; molecular pathology; dysregulated signaling pathways; genetic and epigenetic alterations; therapeutic resistance; novel molecular biomarkers; therapeutic strategies; in vitro and in vivo models

Overcoming Resistance to Immune Checkpoint Inhibitors in Cancer: Mechanisms, Models, and Therapeutic Strategies

edited by Nai-Yun Sun,

Yoshimasa Tanaka

and

Hsin-Fang Tu

submission deadline 15 Jun 2026 | Viewed by 100 | Submission Open

Keywords: immune checkpoint inhibitors; primary resistance; acquired resistance; tumor microenvironment; immune exhaustion; preclinical cancer models; genetic and epigenetic alterations; excluded/desert tumors; inflamed tumors; cancer immunotherapy

Molecular Mechanism of Liver Transplantation

edited by Carmen Peralta and Juan Carlos Cutrin

submission deadline 20 Jun 2026 | 1 articles | Viewed by 4436 | Submission Open

Keywords: liver transplantation; ischemia-reperfusion injury; signaling pathways; graft dysfunction; sterile inflammation; liver regeneration; fatty grafts; normothermic machine perfusion; defatting strategies

(This special issue belongs to the Section Tissues and Organs)

Decoding the Complexity of Angiogenesis: Insights into Vascular Formation and Disease

edited by

Kay-Dietrich Wagner

submission deadline 20 Jun 2026 | 3 articles | Viewed by 3526 | Submission Open

Keywords: angiogenesis; vasculogenesis; development; physiological angiogenesis; pathophysiology; cell– cell communication; cell signaling

(This special issue belongs to the Section Cells of the Cardiovascular System)

Displaying special issue 451-500 on page 10 of 14.

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