Special Issues

Cells publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Tumor Immune Responsiveness in the Era of T Cell Immunotherapy
edited by and
submission deadline 30 Jan 2026 | Viewed by 26 | Submission Open
Keywords: T cell-mediated immunity; cancer immune responsiveness; cytokine modulation
Ubiquitin Ligases in Health and Diseases
edited by Haitao Luan
submission deadline 30 Jan 2026 | Viewed by 11 | Submission Open
Keywords: ubiquitination; E3 ubiquitin ligase; Proteasome; protein degradation; cell cycle regulation; immune response; neurodegeneration; cancer; autoimmune disorders; therapeutic targeting
(This special issue belongs to the Section Cell Signaling)
Advanced Technology for Cellular Imaging
edited by Alessandro Grinzato, and
submission deadline 31 Jan 2026 | 7 articles | Viewed by 15754 | Submission Open
Keywords: electron tomography; fluorescence microscopy; live cell imaging; multimodal imaging; super resolution microscopy; cell– cell interaction
(This special issue belongs to the Section Cell Methods)
Molecular and Cellular Mechanisms of Cardiovascular and Metabolic Diseases
edited by
submission deadline 31 Jan 2026 | 5 articles | Viewed by 12539 | Submission Open
Keywords: mitochondrial dysfunction; endoplasmic reticulum (ER) stress; oxidative/nitrosative stress; diabetes; obesity; diet; atherosclerosis; hypertension; metabolomics; cell death; nutraceuticals/functional foods
(This special issue belongs to the Section Cells of the Cardiovascular System)
Emerging Targets and Therapeutic Potential Drugs in Tumor Progression and Therapeutic Resistance
edited by , and Yuancheng Li
submission deadline 31 Jan 2026 | 2 articles | Viewed by 4324 | Submission Open
Keywords: cancer; tumor progression; therapeutic resistance; molecular targets; tumor microenvironment; innovative therapies; targeted drug delivery; natural product
(This special issue belongs to the Section Cell Microenvironment)
Renewing Reasons to Believe in Gene Therapies for Epilepsy
edited by Casper Gøtzsche
submission deadline 31 Jan 2026 | 2 articles | Viewed by 3599 | Submission Open
Keywords: epilepsy; seizure; gene therapy; gene editing; disease modification; transformative; unmet need
(This special issue belongs to the Section Cells of the Nervous System)
Neuro-Oncological Advances in Stem Cell Research: A New Era in Brain Tumor Therapy submission deadline 31 Jan 2026 | Viewed by 190 | Submission Open
Keywords: brain tumor genetics and epigenetics; brain tumor stem cells; stem cell therapy against brain tumors; mesenchymal stem cells; iPSC; resistance to therapy
(This special issue belongs to the Section Stem Cells)
Diagnostic and Therapeutic Application of Extracellular Vesicles (EV) submission deadline 31 Jan 2026 | Viewed by 165 | Submission Open
Keywords: extracellular vesicles (EVs); diseases biomarkers; therapeutic targets; drugs delivery; engineered extracellular vesicles; EVs therapeutic applications
Single-Molecule Tracking for Live Cells
edited by
submission deadline 31 Jan 2026 | Viewed by 136 | Submission Open
Keywords: single-molecule level; many-molecule level; biological cell; diluted liquids; single-molecule localization microscopy; nanoscopy; modeling; diffusion; theory
Autophagy and Neurodegeneration: Unveiling Cellular Pathways in ALS and Beyond
edited by Valeria Gerbino
submission deadline 31 Jan 2026 | Viewed by 129 | Submission Open
Keywords: autophagy; neurodegeneration; amyotrophic lateral sclerosis (ALS); protein aggregation; cellular homeostasis; lysosomal dysfunction; neuronal health; therapeutic targets; molecular pathways; neuroprotective strategies
(This special issue belongs to the Section Cells of the Nervous System)
New Advances in Tissue Engineering and Regeneration submission deadline 31 Jan 2026 | Viewed by 95 | Submission Open
Keywords: tissue regeneration; tissue engineering; regenerative medicine; musculoskeletal tissues; biomaterials; stem cells; 3D bioprinting; scaffold design; cell therapy; organoids; translational research
(This special issue belongs to the Section Tissues and Organs)
Acute Myeloid Leukemia: Unraveling Molecular Drivers, Cellular Plasticity, and Therapeutic Vulnerabilities
edited by Fabio Guolo
submission deadline 31 Jan 2026 | Viewed by 51 | Submission Open
Keywords: acute myeloid leukemia (AML); hematologic malignancy; AML classification; myeloid precursors; hematopoiesis; high-risk AML; biomarkers
(This special issue belongs to the Section Cellular Immunology)
Human Organoids: A New Frontier in Disease Modeling
edited by and Umesh Kumar
submission deadline 31 Jan 2026 | Viewed by 46 | Submission Open
Keywords: 3D organ culture; embryonic stem cells; induced pluripotent stem cells; 3D bioprinting; personalized medicine; regenerative medicine
(This special issue belongs to the Section Tissues and Organs)
New Trends and Advances in Molecular Targeted Therapy for Cancer
edited by Dhivya Sridaran and
submission deadline 31 Jan 2026 | Viewed by 32 | Submission Open
Keywords: cancer targeted therapy; antibodies; small-molecule inhibitors; antibody– drug conjugates; combination therapies
(This special issue belongs to the Section Cell and Gene Therapy)
Examining the Cellular Biology of Adenovirus
edited by Susan J. Morris, Adam C. T. Gillman and Erwan Sallard
submission deadline 31 Jan 2026 | Viewed by 30 | Submission Open
Keywords: adenovirus; replication; maturation; transduction; tropism; intracellular trafficking; targeting; virus– host interactions; transcriptome
Genetics and Gene Regulation
edited by and
submission deadline 31 Jan 2026 | Viewed by 25 | Submission Open
Keywords: genetics; gene regulation; human diseases
Cell Behavior Under Blood Flow
edited by Alexander Gural, Ivana Pajic-Lijakovic and
submission deadline 31 Jan 2026 | Viewed by 23 | Submission Open
Keywords: blood flow; shear stress; red blood cells; white blood cells; platelets; endothelial cells; cell stimulation; mechanical stress
Cellular and Molecular Mechanisms in Immune Regulation—Second Edition
edited by Fábio Rinaldo Santori and Natalia B. Ivanova
submission deadline 31 Jan 2026 | Viewed by 17 | Submission Open
Keywords: innate immunity; dendritic cells; macrophages; T cells; B cells; cytokines; immunotherapy
(This special issue belongs to the Section Cellular Pathology)
The Language of Neural Cells: Decoding Molecular Signaling in Neurodevelopmental and Neuro-Oncological Disorders
edited by Marilena Briglia, and Adriana C. E. Graziano
submission deadline 31 Jan 2026 | Viewed by 16 | Submission Open
Keywords: neural cells; molecular signaling; neurodevelopmental disorders; neuro-oncological disorders; transcriptional dysregulation
(This special issue belongs to the Section Cells of the Nervous System)
Biochemical Mechanisms and Physiological Implication of Stem Cell Differentiation submission deadline 31 Jan 2026 | Viewed by 9 | Submission Open
Keywords: stem cells; differentiation; 3D cultures; co-cultures; biochemistry; physiology; epigenetics
(This special issue belongs to the Section Stem Cells)
Advances in the Role of Lipid Signaling in Diseases
edited by and
submission deadline 5 Feb 2026 | Viewed by 7 | Submission Open
Keywords: lipid signaling; membrane lipid dynamics; autophagy; disease pathology; mitochondria; transcription; protein degradation
Role of Alpha-Synuclein in Neurodegenerative Diseases
edited by
submission deadline 10 Feb 2026 | Viewed by 72 | Submission Open
Keywords: Alpha-; Beta-; and Gamma-synuclein; synucleinopathies; neurodegeneration; neuroinflammation; authophagy; Parkinson's disease; non-motor symptoms; Alzheimer's disease; multiple system atrophy; psychiatric diseases
(This special issue belongs to the Section Cellular Aging)
Decoding Cellular Organization Through Spatial Omics
edited by Elizabeth Neumann
submission deadline 10 Feb 2026 | Viewed by 1 | Submission Open
Keywords: spatial proteomics; lipomics; cellular architecture; biomolecular interactions; bioinformatics; integrative biology
Exclusive Review Papers in Autophagy—Second Edition
edited by
submission deadline 15 Feb 2026 | 4 articles | Viewed by 11136 | Submission Open
Keywords: biquitination; autophagy; peroxisomes; macroautophagy; pexophagy; mitophagy; lysosome; vacuole; organellar homeostasis; posttranslational modifications; lipids; signaling cascades
(This special issue belongs to the Section Autophagy)
State-of-the-Art Research on Histone Deacetylases (HDACs) and Histone Acetyltransferases (HATs)
edited by
submission deadline 15 Feb 2026 | 3 articles | Viewed by 4823 | Submission Open
Keywords: histone deacetylases; cancer; metabolism; immunotherapy; tumor microenvironment; DNA damage response; cell cycle
(This special issue belongs to the Section Cell Nuclei: Function, Transport and Receptors)
Spotlight on Natural Killer Cells in Immuno-Oncology submission deadline 15 Feb 2026 | 1 articles | Viewed by 2093 | Submission Open
Keywords: natural killer (NK) cells; cancer stem cells (CSCs); poorly differentiated tumors; differentiation; aggressive tumors; suppressor cells
(This special issue belongs to the Section Cellular Immunology)
Cellular Mechanisms and Therapies of Hematologic Malignancies
edited by Sayantani Sinha and Stanley Chun-Wei Lee
submission deadline 15 Feb 2026 | Viewed by 18 | Submission Open
Keywords: AML; ALL and CLL; targeted therapy; combination therapy; small molecule inhibitors; immunotherapy; RNA in hematopoiesis; overcoming resistance
(This special issue belongs to the Section Cellular Pathology)
Cancers and Metabolic Diseases—the Molecular Players in the Game
edited by
submission deadline 15 Feb 2026 | Submission Open
Keywords: metabolism; bioenergetics; signaling; cytokines; molecular; mechanisms; receptors; design; therapeutics
Phosphodiesterases (PDEs): Therapeutic Targets in Human Health and Disease
edited by , , Michy P. Kelly and Leila Gobejishvili
submission deadline 20 Feb 2026 | 14 articles | Viewed by 23787 | Submission Open
Keywords: cyclic nucleotide phosphodiesterase; PDE; cAMP; cGMP; signal transduction
(This special issue belongs to the Section Cell Microenvironment)
Motor Neuron Diseases: From Molecular Basic Research to Diagnosis and Therapeutics Implications
edited by and Elisabetta Zucchi
submission deadline 20 Feb 2026 | 3 articles | Viewed by 4598 | Submission Open
Keywords: motor neuron; genetics; oxidative stress; misfolded protein aggregates; biomarkers; gene therapy
(This special issue belongs to the Section Cells of the Nervous System)
Ovarian Cancer and Endometriosis
edited by and
submission deadline 20 Feb 2026 | 2 articles | Viewed by 2114 | Submission Open
Keywords: ovarian cancer; endometriosis; microenvironment; cell-cell interaction; drug resistance; natural product
(This special issue belongs to the Section Cellular Pathology)
Molecular Insight into the Pathogenesis of Spontaneous Preterm Birth
edited by Khondoker M. Akram
submission deadline 20 Feb 2026 | 2 articles | Viewed by 1846 | Submission Open
Keywords: pathogenesis of preterm birth; placental dysfunctions in preterm birth; environmental impacts on placental function in preterm birth; vaginal dysbiosis in preterm birth
(This special issue belongs to the Section Cellular Pathology)
T Cells in Inflammation and Cancer
edited by
submission deadline 20 Feb 2026 | 1 articles | Viewed by 1281 | Submission Open
Keywords: T cell; immunity; disease; infection; cancer; inflammation; pathology; immunotherapy
(This special issue belongs to the Section Cellular Immunology)
Autophagic Signatures in Health and Disease: Molecular Insights and Clinical Applications submission deadline 20 Feb 2026 | Viewed by 21 | Submission Open
Keywords: autophagy; pathology; physiology; therapy; methods
(This special issue belongs to the Section Autophagy)
Natural Products and Their Derivatives Against Human Disease
edited by
submission deadline 25 Feb 2026 | 4 articles | Viewed by 6290 | Submission Open
Keywords: natural products; immunomodulatory; diseases; molecular mechanism of immunity
(This special issue belongs to the Section Plant, Algae and Fungi Cell Biology)
Molecular, Cellular and Biochemical Approaches of Anti-Cancer Drugs submission deadline 25 Feb 2026 | Viewed by 12 | Submission Open
Keywords: anti-cancer drugs; chemosensitizers; multidrug resistance; cellular techniques; nanoparticle delivery; in silico studies; in vivo studies; targeted therapies; cancer progression; bioactive compounds
Molecular and Cellular Mechanisms of Ischemic Stroke
edited by Milani Deb-Chatterji
submission deadline 25 Feb 2026 | Submission Open
Keywords: ischemic stroke; neuroinflammation; blood– brain barrier; neurovascular unit; molecular targets for stroke therapy
Mitophagy and Mitochondrial Quality Control in Neurodegenerative Disorders
edited by Mohamed Eldeeb
submission deadline 27 Feb 2026 | 1 articles | Viewed by 659 | Submission Open
Keywords: protein degradation; protein quality control; proteasome; ubiquitin; autophagy; mitophagy; mitochondrial quality control; mitochondrial import; proteolysis; neurodegeneration
(This special issue belongs to the Section Mitochondria)
Targeting of Cancer Cells with Small Molecule Drugs
edited by
submission deadline 27 Feb 2026 | Viewed by 25 | Submission Open
Keywords: small molecule drugs; cancer cell targeting; targeted cancer therapy; drug delivery systems; precision oncology
(This special issue belongs to the Section Cellular Pathology)
Cellular Pathology: Emerging Discoveries and Perspectives in the USA submission deadline 28 Feb 2026 | 1 articles | Viewed by 632 | Submission Open
Keywords: cellular pathology; diseases; mechanisms
(This special issue belongs to the Section Cellular Pathology)
Signal Transduction and Targeted Therapy for Tumors submission deadline 28 Feb 2026 | Viewed by 394 | Submission Open
Keywords: cancer progression; metastasis; invasion; cancer signaling; cell communication; cancer neuroscience; tumor angiogenesis; target therapy; immunotherapy; drug resistance; anti-tumor therapy
(This special issue belongs to the Section Cell Signaling)
Role of RNA as Regulator, Therapeutic Target and Probe for Early Disease Diagnosis
edited by
submission deadline 28 Feb 2026 | Viewed by 315 | Submission Open
Keywords: coding RNAs; non-coding RNAs (ncRNAs); regulatory RNAs; RNA-based diagnostics; disease biomarkers; RNA monitoring techniques; molecular probes; RNA interference (RNAi)
(This special issue belongs to the Section Cell Nuclei: Function, Transport and Receptors)
Osteoporosis Treatment: Targeting Osteoclast and Osteoblast Function with microRNA Therapeutics submission deadline 28 Feb 2026 | Viewed by 231 | Submission Open
Keywords: osteoporosis; microRNA; osteoblasts; osteoclasts; osteocytes; fracture; bone remodeling
(This special issue belongs to the Section Tissues and Organs)
Parkinson's Disease: Advances in Molecular Understanding and Emerging Therapies
edited by and Sara Elfarrash
submission deadline 28 Feb 2026 | Viewed by 139 | Submission Open
Keywords: Parkinson’ s disease; atypical Parkinsonism; neurodegeneration; neuroinflammation; alpha-synuclein; disease models; brain organoids; human induced pluripotent stem cells (iPSCs); transcriptomics; proteomics; multi-omics; spatial biology; multiplex imaging; PD genetics
(This special issue belongs to the Section Cellular Aging)
Kidney Disease: The Role of Cellular Mechanisms in Renal Pathology
edited by
submission deadline 28 Feb 2026 | Viewed by 103 | Submission Open
Keywords: kidney fibrosis; acute kidney injury (AKI); chronic kidney disease (CKD); epithelial-to-mesenchymal transition (EMT); renal cell populations; stem cell therapy; renal regeneration; inflammation in kidney disease; cell-based models; renal repair mechanisms
(This special issue belongs to the Section Tissues and Organs)
Recent Advances in Microfluidics and Organoids for Biomedical Applications
edited by Lionel Fernel Gamarra
submission deadline 28 Feb 2026 | Viewed by 49 | Submission Open
Keywords: microfluidics; organoids; biomimetic models; organ-on-a-chip; tissue engineering; pharmacology; biosensors; computational modeling; artificial intelligence; nanomedicine; personalized medicine; bioprinting; in silico; induced pluripotent stem cells (iPSCs); mesenchymal and pluripotent stem cells
(This special issue belongs to the Section Tissues and Organs)
Molecular Insights into Inherited Metabolic Disorders
edited by Paul Gissen
submission deadline 28 Feb 2026 | Viewed by 35 | Submission Open
Keywords: metabolic disorders; enzyme defects; protein misfolding; metabolic pathways; cellular metabolism; molecular pathology; disease mechanisms; therapeutic targets; organelle dysfunction; metabolic networks
(This special issue belongs to the Section Cellular Metabolism)
Cellular and Molecular Mechanisms in Gynecological Disorders—Second Edition
edited by
submission deadline 28 Feb 2026 | Viewed by 31 | Submission Open
Keywords: uterus; ovary; fallopian tubes; cervix; vagina; endometriosis; polycystic ovary syndrome; primary ovarian insufficiency; ovarian cysts; adenomyosis; endometriosis; leiomyoma (uterine fibroids); pathways; endometrial cancer; leiomyosarcoma; breast cancer; cell atlas; biomarkers; stem cells; transcriptome; proteomics; epigenome; female infertility
(This special issue belongs to the Section Cellular Pathology)
The Lipid Metabolism and Signaling in Dry Eye Disease
edited by Ni Made Airanthi Kusuma Widjaja-Adhi and Marcin Golczak
submission deadline 28 Feb 2026 | Viewed by 28 | Submission Open
Keywords: lipid metabolism; meibogenesis; dry eye disease (DED); meibomian gland dysfunction (MGD); ocular surface; neuroinflammation; tear film; lipidomics; spatial transcriptomics; therapeutics development; molecular mechanisms
Cellular and Molecular Mechanisms in Sepsis: Pathogenesis, Immune Response, and Therapeutic Strategies
edited by and
submission deadline 28 Feb 2026 | Viewed by 19 | Submission Open
Keywords: sepsis; cytokine signaling; immune cell dynamics; epigenetic regulation; metabolic reprogramming; non-coding RNAs; redox signaling; receptor polymorphisms; systems immunology; single-cell omics
(This special issue belongs to the Section Cellular Pathology)
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