Special Issues

Cells publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Systemic Sclerosis: Cellular Mechanisms, Innovative Diagnostics and Advanced Therapeutics
edited by Muhammad Soyfoo
submission deadline 25 Jun 2026 | Viewed by 93 | Submission Open
Keywords: systemic sclerosis; fibrosis; myofibroblasts; immune dysregulation; endothelial dysfunction; extracellular matrix (ECM); autoimmune disease
Inflammation and Atherosclerosis: Emerging Mechanisms, Biomarkers and Therapeutic Opportunities
edited by Victoria McGilligan
submission deadline 25 Jun 2026 | Viewed by 77 | Submission Open
Keywords: atherosclerosis; inflammation; inflammatory biomarkers; anti-inflammatory therapies; plaque vulnerability; diagnostics and prognostics
The Dual Role of Extracellular Vesicles in Neurodegeneration: Disease Biomarkers and Drug Delivery Platforms Within the Matrix Microenvironment submission deadline 25 Jun 2026 | Viewed by 71 | Submission Open
Keywords: extracellular vesicles; neurodegenerative diseases; extracellular matrix; biomarkers; therapeutic applications; drug delivery
(This special issue belongs to the Section Intracellular and Plasma Membranes)
Diabetes-Induced Organ Damage: Cellular Mechanisms and Therapeutic Opportunities submission deadline 30 Jun 2026 | 8 articles | Viewed by 41845 | Submission Open
Keywords: diabetes mellitus; vascular lesions; nephropathy; cardiomyopathy; neuropathy; retinopathy; therapeutic opportunities
(This special issue belongs to the Section Tissues and Organs)
New Research on Immunity and Inflammation in Cardiovascular Disease
edited by Pavel Poredoš
submission deadline 30 Jun 2026 | 7 articles | Viewed by 14205 | Submission Open
Keywords: inflammation; atherosclerosis; coronary artery disease; peripheral arterial disease; cerebrovascular disease; venous thromboembolic disease; circulating biomarkers; anti-innflammatory treatment of cardiovascular disease
(This special issue belongs to the Section Cells of the Cardiovascular System)
Exclusive Review Papers in Parkinson's Research
edited by and Ronald F. Pfeiffer
submission deadline 30 Jun 2026 | 2 articles | Viewed by 12276 | Submission Open
Keywords: Parkinson’ s disease; alpha-synuclein; substantia nigra; mitochondria; non-motor symptoms; dopamine; levodopa
(This special issue belongs to the Section Cellular Aging)
Role of Calpains in Health and Diseases
edited by and Peter A. Greer
submission deadline 30 Jun 2026 | 6 articles | Viewed by 9566 | Submission Open
Keywords: calpain; physiology; biochemistry; disease; mutation; target; inhibitor
(This special issue belongs to the Section Cellular Pathology)
Emerging Topics in Smooth Muscle Cell Fate and Plasticity in Atherosclerosis submission deadline 30 Jun 2026 | 5 articles | Viewed by 7022 | Submission Open
Keywords: vascular smooth muscle cells; lineage tracing; fate mapping; VSMC plasticity; (single cell) (spatial) omics; vascular heterogeneity; atherosclerosis
(This special issue belongs to the Section Cellular Pathology)
Pathology and Treatments of Amyotrophic Lateral Sclerosis (ALS)
edited by Laxman Gangwani
submission deadline 30 Jun 2026 | 2 articles | Viewed by 6443 | Submission Open
Keywords: amyotrophic lateral sclerosis (ALS); pathology; molecular mechanisms; treatments; symptom management; biological mechanisms; risk factors; innovative treatments
(This special issue belongs to the Section Cellular Pathology)
Myocardial Ischemia/Reperfusion Injury: Mechanisms and New Directions in Cardioprotection
edited by Sauri Hernandez-Resendiz
submission deadline 30 Jun 2026 | 2 articles | Viewed by 6432 | Submission Open
Keywords: myocardial infarction; heart failure; ischemia/reperfusion injury; no-reflow phenomenon; oxidative stress; cell death; cardiac metabolism; mitochondrial quality control; inflammation; cardioprotection
(This special issue belongs to the Section Tissues and Organs)
Study on Immune Activity of Natural Products
edited by Xiu-Min Li
submission deadline 30 Jun 2026 | 3 articles | Viewed by 3600 | Submission Open
Keywords: natural products; bioactive compounds; immune activity; immunomodulation; inflammation; autoimmune diseases; immunotherapy; therapeutic potential
MicroRNAs: Regulators of Cellular Fate
edited by
submission deadline 30 Jun 2026 | 2 articles | Viewed by 2344 | Submission Open
Keywords: microRNA targets; microRNA conservation; microRNA pathway; microRNA mimics; microRNA antagonist; disease biomarker
AMPK: From Mechanisms to New Therapies submission deadline 30 Jun 2026 | 2 articles | Viewed by 1845 | Submission Open
Keywords: metabolism; AMPK; cancer; biosensors; reproduction; metabolic disorders; therapies
The Role of T Cells and Cellular Signalling in Immune Diseases
edited by Daniela Gallo
submission deadline 30 Jun 2026 | 1 articles | Viewed by 1534 | Submission Open
Keywords: T cells; autoimmune disorders; autoimmune endocrine disorders; targeted therapies
(This special issue belongs to the Section Cellular Immunology)
Emerging Topics in Cachexia
edited by Gabriela Salim Ferreira De Castro
submission deadline 30 Jun 2026 | 1 articles | Viewed by 1276 | Submission Open
Keywords: cachexia; skeletal muscle loss; adipose tissue loss; inflammation; sarcopenia; cancer; body composition; biomarkers
Protein and RNA Regulation in Cells
edited by and
submission deadline 30 Jun 2026 | 2 articles | Viewed by 1218 | Submission Open
Keywords: gene expression; post-transcriptional regulation; post-translational modifications; non-coding RNAs; regulatory networks; protein degradation; RNA decay
Understanding Nasal Inflammation: The Interplay of Diagnosis, Endotypes, and Environmental Shifts
edited by Simonetta Masieri and
submission deadline 30 Jun 2026 | 1 articles | Viewed by 978 | Submission Open
Keywords: rhinology; allergy; immunology; environment; pollution; microbiome; inflammation; united airway disease; lymphocyte cells; interleukins
(This special issue belongs to the Section Tissues and Organs)
Extracellular Vesicles and Cell Therapies in Regenerative Nephrology and Urology
edited by and Ciro Tetta
submission deadline 30 Jun 2026 | 1 articles | Viewed by 836 | Submission Open
Keywords: extracellular vesicles (EVs); microRNA (miRNA); acute kidney injury (AKI); chronic kidney disease (CKD); glomerulonephritis; kidney transplantation; fibrosis; mesenchymal stromal cells (MSCs); engineered EVs; single-cell and spatial omics; machine learning and artificial intelligence; ; precision nephrology; GMP manufacturing; regenerative medicine; biomarkers; artificial intelligence (AI)
(This special issue belongs to the Section Cell Microenvironment)
Cellular and Molecular Mechanisms in Gastrointestinal Diseases submission deadline 30 Jun 2026 | Viewed by 551 | Submission Open
Keywords: gastrointestinal pathophysiology  ; epithelial– mesenchymal transition (EMT)  ; inflammation and immune regulation  ; tumor microenvironment  ; cell signaling pathways  ; stem cell biology in GI tract  ; molecular biomarkers  ; organoids and disease modeling  ; microbiome– host interactions  ; drug discovery
(This special issue belongs to the Section Tissues and Organs)
Retinoic Acid and Retinoid X Receptors - Series II submission deadline 30 Jun 2026 | Viewed by 523 | Submission Open
Keywords: nuclear receptor signaling; retinoic acid receptor; retinoid X receptor; pharmacology; structure/function relationships; genomic and non-genomic signaling; post-translational modification; homeostasis and disease; development; origin and evolution
(This special issue belongs to the Section Cell Nuclei: Function, Transport and Receptors)
Kidney and Lung Disorders: The Role of Tubular and Alveolar Epithelia in Health, Disease, Infection, and Organ Crosstalk
edited by Aparna Renigunta and
submission deadline 30 Jun 2026 | Viewed by 405 | Submission Open
Keywords: renal tubular disorders; alveolar lung diseases; transport mechanism; intracellular signaling; viral infection; crosstalk; dialysis; ventilation
Thoracic Tumors: Decoding Cellular Heterogeneity, Tumor Microenvironment Crosstalk, and Therapeutic Vulnerabilities
edited by and Dragana Jovanovic
submission deadline 30 Jun 2026 | 1 articles | Viewed by 373 | Submission Open
Keywords: NSCLC; SCLC; mesothelioma; thymoma; thymic carcinoma; immunotherapy; molecular therapy; chemotherapy
(This special issue belongs to the Section Cell Microenvironment)
Cellular and Molecular Mechanisms in Reproductive Biology and Fertility
edited by and Antonio Malvasi
submission deadline 30 Jun 2026 | Viewed by 330 | Submission Open
Keywords: gametogenesis; fertilization; fertility; endocrinology; implantation; gametogenesis regulation; embryo– maternal interaction; reproductive signaling; IVF; in vitro fertilization; ovarian stimulation
(This special issue belongs to the Section Reproductive Cells and Development)
Recent Advances in Extracellular-Intracellular Communication and Cancer Therapies
edited by Ana Rita Carlos
submission deadline 30 Jun 2026 | Viewed by 314 | Submission Open
Keywords: extracellular matrix; ECM– cell communication; integrins; cytoskeleton; cancer therapies
Nuclear Pore Complex in Nanomedicine: Third Edition
edited by
submission deadline 30 Jun 2026 | Viewed by 300 | Submission Open
Keywords: intracellular transport; NPC; mitosis; nano; cancer; brain
Crossroad Between Oxidative Stress and DNA Damage and Repair in Stroke
edited by , and Moorthi Ponnusamy
submission deadline 30 Jun 2026 | Viewed by 264 | Submission Open
Keywords: oxidative stress; DNA damage; DNA repair; stroke; ischemic stroke; neuroinflamamtion; intracranial hemorrhagic stroke; neuronal death
(This special issue belongs to the Section Cellular Neuroscience)
The Cross-Talk Between Obesity and Metabolism
edited by
submission deadline 30 Jun 2026 | Viewed by 254 | Submission Open
Keywords: obesity; metabolic disorders; insulin resistance; adipose tissue; inflammation; glucose metabolism; lipid metabolism; cardiovascular disease; type 2 diabetes; therapeutic targets
The Role of PPARs in Disease - Volume IV submission deadline 30 Jun 2026 | Viewed by 232 | Submission Open
Keywords: PPAR; immune function; liver; adipose tissue; cardiovascular system; muscle; brain; neurological disease; psychiatric diseases; cancer; transcriptional regulation; ligands; agonists/antagonists
(This special issue belongs to the Section Cells of the Cardiovascular System)
Hematopoietic Cell Lines as Models for Leukemia and Lymphoma
edited by Stefan Nagel
submission deadline 30 Jun 2026 | Viewed by 219 | Submission Open
Keywords: hematopoiesis; leukemia; lymphoma; transcription factor; homeobox genes
Neuromuscular Disorders: Advances in Cellular and Molecular Understanding, Emerging Therapies, and Outcome Measures
edited by and
submission deadline 30 Jun 2026 | Viewed by 206 | Submission Open
Keywords: neuromuscular disorders; pathophysiology; biomarkers; treatment; impairment and disability measures; outcome measures
(This special issue belongs to the Section Tissues and Organs)
Cellular and Molecular Mechanisms of Hepatobiliary Diseases submission deadline 30 Jun 2026 | Viewed by 185 | Submission Open
Keywords: hepatobiliary diseases; bile metabolism; hepatobiliary models; artificial intelligence; cholestatic diseases; systems medicine; spatio-temporal liver models
(This special issue belongs to the Section Tissues and Organs)
Extracellular Vesicles in Neurodegenerative Diseases: From Biomarker Discovery to Precision Therapeutics
edited by Mangesh Dattu Hade
submission deadline 30 Jun 2026 | Viewed by 179 | Submission Open
Keywords: neurodegenerative diseases; extracellular vesicles; Alzheimer's disease; Parkinson's disease; multiple sclerosis; blood– brain barrier; neuroinflammation; biomarker discovery; EV-based therapeutics; precision medicine
(This special issue belongs to the Section Cellular Aging)
Mitochondrial Dynamics and Remodelling
edited by Edmund Carvalho
submission deadline 30 Jun 2026 | Viewed by 159 | Submission Open
Keywords: mitochondrial dynamics; fission; fusion; mitophagy; cristae remodeling; bioenergetics; ER– mitochondria contacts; immune reprogramming; signaling pathways; therapeutic targeting
Nuclear Organization and Nucleocytoplasmic Transport in Neuronal Development and Disease: Mechanisms and Therapeutic Opportunities submission deadline 30 Jun 2026 | Viewed by 147 | Submission Open
Keywords: nuclear organization; nucleocytoplasmic transport; neuronal development; neurodegeneration; nuclear pore complex (NPC); nuclear lamina; RNA trafficking; chromatin regulation; therapeutic targeting; neurodevelopmental disorders
(This special issue belongs to the Section Cellular Neuroscience)
Cellular Signalling Pathways in the Endocrine Pancreas and Diabetes
edited by
submission deadline 30 Jun 2026 | Viewed by 146 | Submission Open
Keywords: diabetes; cell signalling; molecular mechanisms; cell stress; endocrine pancreas; β -cells
(This special issue belongs to the Section Cell Signaling)
Translating Extracellular Vesicle Science submission deadline 30 Jun 2026 | Viewed by 144 | Submission Open
Keywords: extracellular vesicles (EVs); EV isolation; EV purification; EV characterization; EV images; EV tracking; EV-based diagnostics; EV-based monitoring; EV therapeutics; blood biomarkers; translational medicine; exosomes; cell signaling
Bone and Tooth Biology: Development and Regeneration
edited by Xiaofang Wang
submission deadline 30 Jun 2026 | Viewed by 144 | Submission Open
Keywords: bone; tooth; osteogenesis; odontogenesis; enamel; dentin; cementum; amelogenesis; dentinogenesis; regeneration; stem cells  
Synaptic Condensates: Liquid–Liquid Phase Separation of Pre- and Postsynaptic Scaffold Proteins in Synapse Development and Memory Formation
edited by Norbert Bencsik and
submission deadline 30 Jun 2026 | Viewed by 142 | Submission Open
Keywords: liquid– liquid phase separation (LLPS); synaptic plasticity; synapse development; postsynaptic density (PSD); scaffold proteins; synaptic dysfunction; neural circuits
(This special issue belongs to the Section Cellular Neuroscience)
Molecular Basis of Gynecological Disorders and Associated Infertility submission deadline 30 Jun 2026 | Viewed by 134 | Submission Open
Keywords: gynecological disorders; endometriosis; polycystic ovary syndrome (PCOS); cervical cancer; ovarian cancer; uterine and vaginal pathologies
(This special issue belongs to the Section Cellular Pathology)
Sex Hormone-Driven Cancers: Molecular Pathogenesis, Metabolic Reprogramming, and Therapeutic Frontiers submission deadline 30 Jun 2026 | Viewed by 125 | Submission Open
Keywords: sex hormones; androgen; estrogen; progesterone; breast cancer; ovarian cancer; endometrial cancer; prostate cancer; metabolic reprogramming; tumor microenvironment; drug resistance; cancer metabolism; metastasis
(This special issue belongs to the Section Cellular Pathology)
Advances in Cell-Based Studies and Therapeutic Approaches for Tissue Regeneration—Second Edition submission deadline 30 Jun 2026 | Viewed by 125 | Submission Open
Keywords: soft/hard tissue regeneration; therapeutic approaches; cell culture studies; inflammation-based diseases; degenerative diseases
(This special issue belongs to the Section Tissues and Organs)
Tau Pathobiology and Excitotoxicity in Neurodegeneration and Epilepsy
edited by Janet Van Eersel
submission deadline 30 Jun 2026 | Viewed by 116 | Submission Open
Keywords: tau; excitotoxicity; dementia; epilepsy; seizures; hyperexcitation
Advances in the Biology and Treatment of T-Cell Lymphoma submission deadline 30 Jun 2026 | Viewed by 111 | Submission Open
Keywords: T-cell lymphoma; cancer biology; oncogenic signaling; cellular mechanisms; cell– cell interactions; targeted therapy
(This special issue belongs to the Section Cellular Immunology)
The Immunology of Allergy and Asthma submission deadline 30 Jun 2026 | Viewed by 110 | Submission Open
Keywords: type 2 immunity; rhinitis; food allergy; anaphylaxis; drug allergy; dermatitis; eczema; airway inflammation; IgE response; tissue remodelling; disease remission
Neural Stem Cells and Progenitors: Mechanisms of Neurogenesis and Regenerative Potential
edited by Lidia De Filippis and Maurizio Gelati
submission deadline 30 Jun 2026 | Viewed by 107 | Submission Open
Keywords: neural stem cells; cancer stem cells; neuroregeneration; neurodegenerative diseases; CNS; neurorepair; neurogenesis; neuroinflammation
Organs-on-Chips and Organoids: From Disease Modeling to Advanced Therapeutics
edited by
submission deadline 30 Jun 2026 | Viewed by 106 | Submission Open
Keywords: organs-on-chips; organoids; disease modeling; tissue engineering; cellular reprogramming; regenerative medicine
Plant Stress Biology Under Biotic and Abiotic Environment submission deadline 30 Jun 2026 | Viewed by 105 | Submission Open
Keywords: abiotic stress; microscopy; molecular biology; photosynthesis; phytohormnes; plant-pathogen interaction; plant physiology; plant biology; transcriptomics
(This special issue belongs to the Section Plant, Algae and Fungi Cell Biology)
Multifaceted Nature of Immune Responses to Viral Infection
edited by Homayon Ghiasi and Susmit Suvas
submission deadline 30 Jun 2026 | Viewed by 105 | Submission Open
Keywords: viral infection; innate and adaptive immunity; protection; RNA and DNA viruses; autoimmunity; immune escape
Inflammation in Target Organs—Second Edition
edited by
submission deadline 30 Jun 2026 | Viewed by 102 | Submission Open
Keywords: inflammation; fibrosis; cardio-renal; vascular; liver; brain
(This special issue belongs to the Section Cellular Immunology)
Melatonin in Neuroprotection: Mechanisms, Mitochondria, and Therapeutic Potential submission deadline 30 Jun 2026 | Viewed by 99 | Submission Open
Keywords: neurodegenerative disorders; melatonin; neuroprotection; mitochondria; oxidative stress; neuroinflammation; mitochondrial dynamics; therapeutic potential
(This special issue belongs to the Section Mitochondria)
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