Special Issue "Chiral Building Blocks via Asymmetric Catalysis"

A special issue of Catalysts (ISSN 2073-4344).

Deadline for manuscript submissions: 15 January 2018

Special Issue Editors

Guest Editor
Prof. Dr. Vito Capriati

Dipartimento di Farmacia-Scienze del Farmaco, Università di Bari “Aldo Moro”, Consorzio C.I.N.M.P.I.S., Via E. Orabona 4, I-70125 Bari, Italy
Website | E-Mail
Phone: +39-080-544-2174
Interests: Functionalized organolithiums; Lithium carbenoid chemistry; Organoboron chemistry; Organofluorine chemistry; Cross-coupling reactions; Heterocyclic chemistry; Strained cycles; Green chemistry; Deep eutectic solvents; Asymmetric synthesis
Guest Editor
Dr. Paola Vitale

Dipartimento di Farmacia-Scienze del Farmaco, Università degli Studi di Bari "A. Moro", Consorzio C.I.N.M.P.I.S., Via E. Orabona 4, I-70125 Bari, Italy
Website | E-Mail
Phone: +39-080-544-2734
Interests: Asymmetric synthesis; Applied biocatalysis; Whole cells biocatalysis; Sustainable chemistry; Green chemistry; Synthesis of bioactive heterocycles; COX inhibitors; Isoxazoles, Isoxazolines; Heterocyclic chemistry

Special Issue Information

Dear Colleagues,

The preparation of natural/un-natural products and synthetic, optically-active pharmaceutical agents, displaying selective biological activity, is a central challenge in chemistry.

A feature common to these compounds is chirality, generally due to the presence of stereocenters. In this context, asymmetric catalysis plays a fundamental role in forging new chemical bonds in a stereocontrolled manner, and, thus, in the preparation of crucial, stereodefined building blocks, which are either important precursors in the synthesis of pharmacologically- and biologically-active compounds or key players for use in drug discovery.

This present Special Issue is aimed at covering a collection of high-caliber papers focusing on novel asymmetric, enantioselective synthetic approaches, and methodologies for the preparation of chiral building blocks, even on a large scale. Contributions from all areas of (transition) metal-, organo-, photoredox- and biocatalysis, also using unconventional and environmentally-friendly reaction media, would be of great interest.

Short communications, full original papers and review articles on emergent and original catalytic approaches for the synthesis of building blocks are welcome as well.

Prof. Dr. Vito Capriati
Dr. Paola Vitale
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Catalysts is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


Chiral Building Blocks,

Asymmetric Catalysis,

(transition) metal-catalysis,




unconventional reaction media,

environmentally-friendly synthesis,

Active Pharmaceutical Ingredients (APIs) synthesis

Published Papers

This special issue is now open for submission, see below for planned papers.

Planned Papers

The below list represents only planned manuscripts. Some of these manuscripts have not been received by the Editorial Office yet. Papers submitted to MDPI journals are subject to peer-review.

Article type: Review article
Tentative Title: One-pot tandem combination of metal- and bio-catalysis in water for the synthesis of chiral molecules
Authors: Nicolas Ríos-Lombardía, Javier González-Sabín and Joaquín García-Álvarez.
Abstract: In recent years chemists have tried to emulate Mother Nature by the development of novel one-pot asymmetric multi-catalytic reactions to construct enantiomerically enriched molecules in a new cleaner and more efficient manner, also fulfilling important Green Chemistry Principles related with the minimization of waste-production, time-consuming and tedious purification steps associated with traditional multi-step processes. In particular, two different catalytic worlds (metal-catalysis and bio-catalysis) have recently converged in the development of new methodologies merging the advantages of both areas.
Thus, the combination of organometallic compounds and enzymes in aqueous media has crossed the frontiers between well-established metal-catalyzed organic reactions (Pd-catalyzed C-C coupling, Wacker oxidation and C-H activation; Cu(I)-catalyzed click chemistry; Ru-catalyzed olefin metathesis; or Au-catalyzed cyclizations) and several biocatalyzed organic transformations (enzymatic reduction, halogenation, ester hydrolysis or epoxidations).

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