Special Issue "Chiral Building Blocks via Asymmetric Catalysis"

A special issue of Catalysts (ISSN 2073-4344).

Deadline for manuscript submissions: closed (15 January 2018)

Special Issue Editors

Guest Editor
Prof. Dr. Vito Capriati

Dipartimento di Farmacia-Scienze del Farmaco, Università di Bari “Aldo Moro”, Consorzio C.I.N.M.P.I.S., Via E. Orabona 4, I-70125 Bari, Italy
Website | E-Mail
Phone: +39-080-544-2174
Interests: Functionalized organolithiums; Lithium carbenoid chemistry; Organoboron chemistry; Organofluorine chemistry; Cross-coupling reactions; Heterocyclic chemistry; Strained cycles; Green chemistry; Deep eutectic solvents; Asymmetric synthesis
Guest Editor
Dr. Paola Vitale

Dipartimento di Farmacia-Scienze del Farmaco, Università degli Studi di Bari "A. Moro", Consorzio C.I.N.M.P.I.S., Via E. Orabona 4, I-70125 Bari, Italy
Website | E-Mail
Phone: +39-080-544-2734
Interests: Asymmetric synthesis; Applied biocatalysis; Whole cells biocatalysis; Sustainable chemistry; Green chemistry; Synthesis of bioactive heterocycles; COX inhibitors; Isoxazoles, Isoxazolines; Heterocyclic chemistry

Special Issue Information

Dear Colleagues,

The preparation of natural/un-natural products and synthetic, optically-active pharmaceutical agents, displaying selective biological activity, is a central challenge in chemistry.

A feature common to these compounds is chirality, generally due to the presence of stereocenters. In this context, asymmetric catalysis plays a fundamental role in forging new chemical bonds in a stereocontrolled manner, and, thus, in the preparation of crucial, stereodefined building blocks, which are either important precursors in the synthesis of pharmacologically- and biologically-active compounds or key players for use in drug discovery.

This present Special Issue is aimed at covering a collection of high-caliber papers focusing on novel asymmetric, enantioselective synthetic approaches, and methodologies for the preparation of chiral building blocks, even on a large scale. Contributions from all areas of (transition) metal-, organo-, photoredox- and biocatalysis, also using unconventional and environmentally-friendly reaction media, would be of great interest.

Short communications, full original papers and review articles on emergent and original catalytic approaches for the synthesis of building blocks are welcome as well.

Prof. Dr. Vito Capriati
Dr. Paola Vitale
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Catalysts is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1300 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Chiral Building Blocks
  • Asymmetric Catalysis
  • (transition) metal-catalysis
  • organo-catalysis
  • photoredox-catalysis
  • biocatalysis
  • unconventional reaction media
  • environmentally-friendly synthesis
  • Active Pharmaceutical Ingredients (APIs) synthesis

Published Papers (2 papers)

View options order results:
result details:
Displaying articles 1-2
Export citation of selected articles as:

Research

Jump to: Review

Open AccessFeature PaperCommunication Whole-Cell Biocatalyst for Chemoenzymatic Total Synthesis of Rivastigmine
Catalysts 2018, 8(2), 55; https://doi.org/10.3390/catal8020055
Received: 16 January 2018 / Revised: 26 January 2018 / Accepted: 29 January 2018 / Published: 31 January 2018
Cited by 2 | PDF Full-text (2297 KB) | HTML Full-text | XML Full-text
Abstract
Biocatalytic processes are increasingly playing a key role in the development of sustainable asymmetric syntheses, which are central to pharmaceutical companies for the production of chiral enantiopure drugs. This work describes a simple and economically viable chemoenzymatic process for the production of (
[...] Read more.
Biocatalytic processes are increasingly playing a key role in the development of sustainable asymmetric syntheses, which are central to pharmaceutical companies for the production of chiral enantiopure drugs. This work describes a simple and economically viable chemoenzymatic process for the production of (S)-rivastigmine, which is an important drug for the treatment of mild to moderate dementia of the Alzheimer’s type. The described protocol involves the R-regioselective bioreduction of an aromatic ketone by Lactobacillus reuteri DSM 20016 whole cells in phosphate buffered saline (PBS) (37 °C, 24 h) as a key step. Biocatalytic performance of baker’s yeast whole cells in water and in aqueous eutectic mixtures have been evaluated and discussed as well. The route is scalable, environmentally friendly, and the target drug is obtained via four steps in overall 78% yield and 98% ee. Full article
(This article belongs to the Special Issue Chiral Building Blocks via Asymmetric Catalysis)
Figures

Graphical abstract

Review

Jump to: Research

Open AccessFeature PaperReview One-Pot Combination of Metal- and Bio-Catalysis in Water for the Synthesis of Chiral Molecules
Catalysts 2018, 8(2), 75; https://doi.org/10.3390/catal8020075
Received: 22 January 2018 / Revised: 7 February 2018 / Accepted: 8 February 2018 / Published: 10 February 2018
Cited by 1 | PDF Full-text (6004 KB) | HTML Full-text | XML Full-text
Abstract
During the last decade, the combination of different metal- and bio-catalyzed organic reactions in aqueous media has permitted the flourishing of a variety of one-pot asymmetric multi-catalytic reactions devoted to the construction of enantiopure and high added-value chemicals under mild reaction conditions (usually
[...] Read more.
During the last decade, the combination of different metal- and bio-catalyzed organic reactions in aqueous media has permitted the flourishing of a variety of one-pot asymmetric multi-catalytic reactions devoted to the construction of enantiopure and high added-value chemicals under mild reaction conditions (usually room temperature) and in the presence of air. Herein, a comprehensive account of the state-of-the-art in the development of catalytic networks by combining metallic and biological catalysts in aqueous media (the natural environment of enzymes) is presented. Among others, the combination of metal-catalyzed isomerizations, cycloadditions, hydrations, olefin metathesis, oxidations, C-C cross-coupling and hydrogenation reactions, with several biocatalyzed transformations of organic groups (enzymatic reduction, epoxidation, halogenation or ester hydrolysis), are discussed. Full article
(This article belongs to the Special Issue Chiral Building Blocks via Asymmetric Catalysis)
Figures

Figure 1

Back to Top