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Cancers publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Molecular Imaging in Oncology: Recent Advances

edited by

Lioe-Fee de Geus-Oei

submission deadline 15 Sep 2025 | 12 articles | Viewed by 33694

Keywords: nuclear medicine; molecular imaging; PET; oncology; cancer; SPECT; precision medicine; personalized medicine; biomarker; targeted radionuclide therapies; personalized dosimetry

(This special issue belongs to the Section Methods and Technologies Development)

Recent Advances in Basic and Clinical Colorectal Cancer Research

edited by

Seiichi Shinji

and

Tomio Arai

submission deadline 15 Sep 2025 | 9 articles | Viewed by 32577

Keywords: anti-cancer therapies; animal models; in vitro assays; clinical trials; clinical oncology; translational medicine; metastasis; immune escape; mutation; targeted therapy

(This special issue belongs to the Section Clinical Research of Cancer)

Dermoscopy in Skin Cancer

edited by

Elisa Zavattaro

and

Paola Savoia

submission deadline 15 Sep 2025 | 9 articles | Viewed by 23192

Keywords: dermoscopy; skin cancer; differential diagnosis; dermoscopy patterns; non-invasive diagnostic tool

(This special issue belongs to the Section Methods and Technologies Development)

Cancer Genetics and Epigenetics: Their Roles and Clinical Implications

edited by

Armita Bahrami

and

Ying Qing

submission deadline 15 Sep 2025 | 5 articles | Viewed by 19625

Keywords: cancer genetics; cancer epigenetics; carcinogenesis; cancer prognosis; cancer therapeutics; genetic mutations; DNA methylation; histone modifications; RNA methylation

(This special issue belongs to the Section Molecular Cancer Biology)

Emerging Trends in Global Cancer Epidemiology: 2nd Edition

edited by Syed Ahsan Raza

submission deadline 15 Sep 2025 | 7 articles | Viewed by 18906

Keywords: cancer epidemiology; global cancer research; incidence; prevention and control strategies; risk factors; data sources and methods; social and environmental impact; population health; emerging trends; survival and mortality

(This special issue belongs to the Section Cancer Epidemiology and Prevention)

Multi-Omics Analysis in the Study of Carcinogenesis

edited by

Dimiter Avtanski

submission deadline 15 Sep 2025 | 3 articles | Viewed by 14246

Keywords: carcinogenesis; cancer initiation and progression; oncology research; multi-omics analyses; genomics; transcriptomics; proteomics; metabolomics

(This special issue belongs to the Section Cancer Pathophysiology)

Radioligand Therapy (RLT) in Neuroendocrine Neoplasms

edited by

Grzegorz Kamiński

submission deadline 15 Sep 2025 | 4 articles | Viewed by 9217

Keywords: neuroendocrine neoplasms (NENs); neuroendocrine tumors (NETs); radioligand therapy (RLT); peptide receptor radionuclide therapy (PRRT)

(This special issue belongs to the Section Cancer Therapy)

Skin Cancers of the Head and Neck

edited by

Cherie-Ann Nathan

and

Shaun A. Nguyen

submission deadline 15 Sep 2025 | 4 articles | Viewed by 8167

Keywords: non-melanoma skin cancer (NMSC); squamous cell carcinoma (SCC); basal cell carcinoma (BCC); melanoma; genomic profiling; immunotherapy

(This special issue belongs to the Section Cancer Therapy)

Artificial Intelligence and MRI Characterization of Tumors: 2nd Edition

edited by

Eliodoro Faiella

Paolo Soda

Domiziana Santucci

and Ermanno Cordelli

submission deadline 15 Sep 2025 | 1 articles | Viewed by 5950

Keywords: cancer; MRI; CT; PET 18F-FDG; PET/CT scintigraphy; artificial intelligence (AI); radiomics convolutional neural networks (CNN)

(This special issue belongs to the Section Methods and Technologies Development)

Genetics of Endometrial Cancer: Latest Insights and Innovations in Research

edited by Ekaterina Olkhov-Mitsel

submission deadline 15 Sep 2025 | 1 articles | Viewed by 2559

Keywords: endometrial carcinoma; genomic landscape; genetic aberrations; molecular biomarkers; hereditary predisposition to cancer; next-generation sequencing; targetable mutations; somatic mutations

(This special issue belongs to the Section Methods and Technologies Development)

MicroRNA and Cancer Immunology

edited by

Behzad Mansoori

submission deadline 15 Sep 2025 | 1 articles | Viewed by 2505

Keywords: microRNA; miRNA; tumor microenvironment; biomarkers; cancer immunology; cancer treatment; therapeutic target; tumor angiogenesis; tumor metastasis

(This special issue belongs to the Section Tumor Microenvironment)

Oxidative Stress and Cancer: Possible Beneficial and Antioxidant Strategies (2nd Edition)

edited by

Rita Rezzani

submission deadline 15 Sep 2025 | 1 articles | Viewed by 1869

Keywords: oxidative; stress; antioxidant; melatonin; carcinogenesis

(This special issue belongs to the Section Molecular Cancer Biology)

Advances in the Treatment of Relapsed and Refractory Multiple Myeloma: Novel Agents, Immunotherapies and Beyond: 2nd Edition

edited by

Klaus Podar

and

Xavier Leleu

submission deadline 15 Sep 2025 | 2 articles | Viewed by 1866

Keywords: myeloma relapse setting; drug development; treatment sequences; immunotherapy

(This special issue belongs to the Section Cancer Immunology and Immunotherapy)

The Role of Epstein–Barr Virus in Human Cancers

edited by

Lucia Mundo

, Cristiana Bellan and

Stefano Lazzi

submission deadline 15 Sep 2025 | Viewed by 347

Keywords: Epstein– Barr virus; cancer; EBV-driven malignancies; tumour microenvironment; immune response; immunotherapy

(This special issue belongs to the Section Infectious Agents and Cancer)

Endothelial Cells in Inflammation, Tissue Repair, Ageing and Cancer: 2nd Edition

edited by

Constantinos Mikelis

submission deadline 15 Sep 2025 | Viewed by 244

Keywords: ageing; angiogenesis; cancer; cytokines; endothelial cells; growth factors; inflammation; tissue repair

(This special issue belongs to the Section Tumor Microenvironment)

Advances in T-Cell Immunotherapy for Acute Myeloid Leukemia

edited by

Pau Montesinos

submission deadline 15 Sep 2025 | Viewed by 211

Keywords: T-cell engager; AML; minimal residual disease; relapse/refractory; high-risk MDS; toxicity; antigen; CAR-T cell; myelosuppression; cytokine release syndrome

(This special issue belongs to the Section Cancer Immunology and Immunotherapy)

Neuroendocrine Neoplasms: Pathogenesis, Diagnostics, and Therapy

edited by

Beata Jabłońska

submission deadline 17 Sep 2025 | 1 articles | Viewed by 3420 | Submission Open

Keywords: neuroendocrine neoplasms; pathogenesis; diagnostics; therapy

(This special issue belongs to the Section Cancer Therapy)

The Clinical Trials and Management of Acute Myeloid Leukemia

edited by

Margaret T. Kasner

submission deadline 19 Sep 2025 | 4 articles | Viewed by 9730 | Submission Open

Keywords: acute myeloid leukemia; clinical trials; translational research; targeted therapies; novel agents

(This special issue belongs to the Section Clinical Research of Cancer)

New Insights into Urologic Oncology

edited by Justin H. Hwang and Song Yi Bae

submission deadline 20 Sep 2025 | 18 articles | Viewed by 46594 | Submission Open

Keywords: urologic cancer; therapeutic resistance; heterogeneity; genomic alterations; lineage plasticity; epigenetic reprogramming

(This special issue belongs to the Section Cancer Therapy)

Research Progress of Cutaneous Squamous and Basal Cell Carcinomas (Volume II)

edited by

Moran Amit

Frederico O. Gleber-Netto

and Neil D. Gross

submission deadline 20 Sep 2025 | 5 articles | Viewed by 17539 | Submission Open

Keywords: tumor immune microenvironment; cutaneous squamous cell carcinoma; immunodeficiency; biomarkers; therapeutics; ultraviolet

(This special issue belongs to the Section Cancer Immunology and Immunotherapy)

Communication and Accessibility in the Tumor Microenvironment as a Therapeutic Target

edited by

Gema Jiménez-González

and Carmen Griñán-Lisón

submission deadline 20 Sep 2025 | 3 articles | Viewed by 9452 | Submission Open

Keywords: tumor microenvironment; cellular communication; tumor secretome; signaling; extracellular matrix; cancer treatment; targeted treatment

(This special issue belongs to the Section Cancer Therapy)

Multimodality Imaging for More Precise Radiotherapy

edited by

Valeria Faccenda

Denis Panizza

and Stefano Arcangeli

submission deadline 20 Sep 2025 | 4 articles | Viewed by 7061 | Submission Open

Keywords: multimodality imaging; radiotherapy; stereotactic radiotherapy

(This special issue belongs to the Section Cancer Therapy)

Immunotherapy of Non-Small Cell Lung Cancer

edited by Aakash P. Desai

submission deadline 20 Sep 2025 | 2 articles | Viewed by 5404 | Submission Open

Keywords: antibody drug conjugates; ADCs; non-small cell lung cancer; NSCLC; interstitial lung disease; ILD; TROP2; ERBB2

(This special issue belongs to the Section Cancer Immunology and Immunotherapy)

Molecular Pathology Insights in Thyroid Cancer

edited by Salma Khan

submission deadline 20 Sep 2025 | Viewed by 239 | Submission Open

Keywords: non-coding RNAs; epigenetics; biomarkers; BRAF mutations; RAS mutations; targeted therapy; precision medicine; genomic profiling; tumor heterogeneity; therapeutic resistance

(This special issue belongs to the Section Cancer Pathophysiology)

Cancer Pain: From Basic Research to Drug Discovery and Clinical Studies (2nd Edition)

edited by

Arpad Szallasi

submission deadline 20 Sep 2025 | Viewed by 212 | Submission Open

Keywords: cancer pain; drug discovery; clinical trials; management

(This special issue belongs to the Section Cancer Survivorship and Quality of Life)

Clinical and Translational Research in Hematological Malignancies

edited by

Elaine Yee Lin Chung

submission deadline 20 Sep 2025 | Viewed by 157 | Submission Open

Keywords: acute myeloid leukemia (AML); acute lymphoblastic leukemia (ALL); diffuse large B-cell lymphoma (DLBCL); follicular lymphoma (FL); marginal zone lymphoma (MZL); mantle cell lymphoma (MCL); multiple myeloma (MM); CAR-T; antibody– drug conjugate (ADC); venetoclax; FLT3 inhibitors; IDH inhibitors

(This special issue belongs to the Section Clinical Research of Cancer)

State of the Art and Advances in Kaposi Sarcoma

edited by

Athanasia Tourlaki

submission deadline 23 Sep 2025 | Viewed by 270 | Submission Open

Keywords: Kaposi sarcoma; human herpes virus 8 (HHV-8); oncogenesis; chemotherapy; targeted therapy; immunotherapy

(This special issue belongs to the Section Clinical Research of Cancer)

Rare Breast Tumors

edited by

Maggie Banys-Paluchowski

and

Maria Luisa Gasparri

submission deadline 25 Sep 2025 | 8 articles | Viewed by 14725 | Submission Open

Keywords: rare breast tumors; rare histology; breast cancer; phylloides tumor; male breast cancer; CUP syndrome; breast implant-associated anaplastic large cell lymphoma; diabetic mastopathy; metaplastic breast cancer; apocrine breast cancer; inflammatory breast cancer; medullary breast cancer; mucinous breast cancer; adenoid cystic carcinoma of the breast; lymphoma of the breast; basal type breast cancer; angiosarcoma of the breast breast neuroendocrine tumors; brain metastases; PET imaging agents (FES; FFNP; and FDHT); microinvasive breast cancer; supraclavicular and contralateral axillary lymph node involvement; ectopic breast tissue; pregnancy-associated breast cancer

(This special issue belongs to the Section Cancer Therapy)

Genomics and Transcriptomics in Sarcoma

edited by George Jour and Jose G. Mantilla

submission deadline 25 Sep 2025 | 2 articles | Viewed by 1625 | Submission Open

Keywords: transcriptomics; single-cell RNA sequencing; machine learning; sarcoma

(This special issue belongs to the Section Molecular Cancer Biology)

Metastatic Progression of Human Melanoma: 2nd Edition

edited by

Jozsef Timar

and

Andrea Ladányi

submission deadline 25 Sep 2025 | 1 articles | Viewed by 1298 | Submission Open

Keywords: human melanoma; metastasis models; oncogenic signaling; organ metastasis; genomics; immune microenvironment; prognosticators; predictors of target therapies

(This special issue belongs to the Section Cancer Pathophysiology)

Giant-Cell-Containing Tumors of Bone—New Insights into Pathobiology, the Clinical Setting and Targeted Therapies

edited by

Ramses Forsyth

and

Pancras Hogendoorn

submission deadline 30 Sep 2025 | 11 articles | Viewed by 33639 | Submission Open

Keywords: giant-cell-containing tumors of bone (GCCTB); giant cell tumor of bone (GCTB); giant cell tumor in Paget's disease; malignant giant cell tumor; giant cell reparative granuloma; fibrohistiocytic tumors and lesions; chondroblastoma; brown tumor; non-ossifying fibroma; chrondromyxoid fibroma; aneurysmal bone cyst; langerhans cell histiocytosis; osteosarcoma; clear cell chondrosarcoma; metastatic carcinoma

(This special issue belongs to the Section Molecular Cancer Biology)

State of the Art and New Approaches to Spinal Cord Tumors

edited by Cédric Y. Barrey and Gabriele Capo

submission deadline 30 Sep 2025 | 8 articles | Viewed by 28469 | Submission Open

Keywords: neurosurgery; spinal cord tumors; ependymoma; microsurgery; neuromonitoring; neuroradiology; neurorehabilitation; neurohistology; neuro-oncology; intramedullary tumors

(This special issue belongs to the Section Methods and Technologies Development)

Gynecologic Cancer: Risk Factors, Interception and Prevention

edited by Brandy Heckman-Stoddard and Goli Samimi

submission deadline 30 Sep 2025 | 9 articles | Viewed by 20142 | Submission Open

Keywords: ovarian cancer; endometrial cancer; cervical cancer; HPV; cancer prevention; gynecologic cancer risk reduction; gynecologic cancer interception; gynecologic cancer clinical trials

(This special issue belongs to the Section Cancer Epidemiology and Prevention)

Novel Approaches and Advances in Interventional Oncology

edited by

Thomas Vogl

and

Hamzah Adwan

submission deadline 30 Sep 2025 | 11 articles | Viewed by 18840 | Submission Open

Keywords: interventional oncological treatments; combination treatments; hypo- and hyper-thermal ablation; transarterial chemoembolization; transarterial chemoperfusion; transarterial embolization; selective internal radiotherapy; immunotherapy

(This special issue belongs to the Section Methods and Technologies Development)

Hematologic Malignancies and Related Disorders: Challenges from Diagnosis to Treatment

edited by

Ioanna Sakellari

and

Eleni Gavriilaki

submission deadline 30 Sep 2025 | 8 articles | Viewed by 16229 | Submission Open

Keywords: hematopoietic cell transplantation; cell therapy; acute myeloid leukemia; graft-versus-host disease; hematologic malignancies; thrombosis; complement; lymphoma; myeloma; COVID-19

(This special issue belongs to the Section Cancer Therapy)

Patient-Centered Outcomes of Colorectal Cancer Surgery

edited by Ira L. Leeds and Zhaomin Xu

submission deadline 30 Sep 2025 | 7 articles | Viewed by 14588 | Submission Open

Keywords: colorectal cancer; quality of life; postoperative outcomes

(This special issue belongs to the Section Clinical Research of Cancer)

The Tumor Microenvironment and Molecular Aberrations Convey Immune Evasion (Volume II)

edited by

Huey-Jen Lin

submission deadline 30 Sep 2025 | 4 articles | Viewed by 13153 | Submission Open

Keywords: CD8+ tumor-infiltrating lymphocytes; cytotoxic T lymphocytes -associated protein 4; dendritic cells; immune evasion; hypoxia-inducible factors; myeloid-derived suppressor cells; natural killer; programmed death receptor and ligand; regulatory T cells; tumor-associated macrophages; tumor microenvironment

(This special issue belongs to the Section Cancer Immunology and Immunotherapy)

Robot-Assisted Radical Prostatectomy for Urologic Cancer: State of the Art

edited by Jakub Dobruch

submission deadline 30 Sep 2025 | 7 articles | Viewed by 10580 | Submission Open

Keywords: prostate cancer; bladder cancer; upper urinary tract tumors; kidney cancer; testicular tumors; molecular markers; lymph node metastasis; diagnosis; radical treatment; systemic treatment

(This special issue belongs to the Section Methods and Technologies Development)

Monoclonal Antibodies in Lymphoma

edited by Donato Mannina

submission deadline 30 Sep 2025 | 3 articles | Viewed by 8297 | Submission Open

Keywords: monoclonal antibodies; immunotherapy; drug immunoconiugates; bispecific antibodies; checkpoints inhibitors; NHL; HL; CLL

(This special issue belongs to the Section Cancer Immunology and Immunotherapy)

Urogenital Neoplasms Pathology

edited by

Carlo Introini

submission deadline 30 Sep 2025 | 4 articles | Viewed by 7292 | Submission Open

Keywords: urethroscopy; bladder cancer; prostate cancer; renal cancer; robotic surgery; laparoscopy; prostate biopsy

(This special issue belongs to the Section Cancer Pathophysiology)

The Application of Laparo-Endoscopic and Robotic Surgery in Cancer Treatments and Research

edited by Yutaro Kato

submission deadline 30 Sep 2025 | 3 articles | Viewed by 5876 | Submission Open

Keywords: cancer; minimally invasive surgery; laparoscopic surgery; endoscopic surgery; robotic surgery; telesurgery; periop-erative outcomes; oncologic outcomes; clinicopathology; molecular biology

(This special issue belongs to the Section Cancer Therapy)

Development, Validation and Application of Advanced Biomarkers in Cerebral Tumours

edited by Alan Jackson

submission deadline 30 Sep 2025 | 3 articles | Viewed by 5419 | Submission Open

(This special issue belongs to the Section Cancer Biomarkers)

Surgical Oncology for Hepato-Pancreato-Biliary Cancer

edited by Zaed Z. R. Hamady

submission deadline 30 Sep 2025 | 5 articles | Viewed by 4495 | Submission Open

Keywords: pancreatic cancer; liver cancer; liver metastases; surgical oncology; multidisciplinary approach

(This special issue belongs to the Section Clinical Research of Cancer)

Adjuvant Therapy for Pancreatic Cancer

edited by Sonam Kumari

submission deadline 30 Sep 2025 | 2 articles | Viewed by 4206 | Submission Open

Keywords: chemotherapy; pancreatic resections; overall survival; gemcitabine; pancreatic ductal adenocarcinoma

(This special issue belongs to the Section Cancer Therapy)

Systematic Reviews and Meta-Analyses of Genitourinary Cancers (2nd Edition)

edited by

Giorgio Treglia

and Ursula Maria Vogl

submission deadline 30 Sep 2025 | 4 articles | Viewed by 4034 | Submission Open

Keywords: systematic review; meta-analysis; oncology; genitourinary cancers; diagnosis; therapy

(This special issue belongs to the Section Systematic Review or Meta-Analysis in Cancer Research)

The Development and Application of Imaging Biomarkers in Cancer

edited by

Abhishek Mahajan

submission deadline 30 Sep 2025 | 2 articles | Viewed by 3959 | Submission Open

Keywords: imaging biomarkers; oncology; cancer imaging; artificial intelligence

(This special issue belongs to the Section Cancer Therapy)

Neurosurgery Research on Brain Tumors: A Focus on Gliomas and Other Intra-axial Brain Tumors

edited by

Andrea Di Cristofori

, Carlo Giussani, Cesare Zoia and Daniele Bongetta

submission deadline 30 Sep 2025 | 2 articles | Viewed by 3659 | Submission Open

Keywords: neurosurgery; glioma; neuropsychology; neurophysiological monitoring; intraoperative imaging (including iMRI and iOUS); neuroanatomy; outcome; prognosis and quality of life; MRI (including fMRI; MR spectroscopy; perfusion and DTI tractography); radiogenomics; multimodal treatments; druggable targets; artificial intelligence and deep learning

(This special issue belongs to the Section Clinical Research of Cancer)

Cancer Risk Factors and Prognosis in Transplant Patients

edited by

Georgios Tsoulfas

submission deadline 30 Sep 2025 | 3 articles | Viewed by 3117 | Submission Open

Keywords: post-transplant malignancy; transplant oncology; liver transplantation; multidisciplinary care; artificial intelligence; precision medicine; immunosuppression; transplant immunology; cancer immunology; cancer diagnosis

(This special issue belongs to the Section Cancer Epidemiology and Prevention)

Merkel Cell Carcinoma: From Molecular Mechanisms to Clinical Therapy—a Selection of Papers from the 8th Nordic/1st European MCC Meeting

edited by

Jürgen C. Becker

Nicole Fischer

, John Paoli and

Weng-Onn Lui

submission deadline 30 Sep 2025 | 2 articles | Viewed by 2924 | Submission Open

Keywords: merkel cell carcinoma; molecular biology; virology; immunology; biomarkers; epidemiology; primary treatment (surgery; radiation therapy); immunotherapy; targeted therapy; clinical trials

(This special issue belongs to the Section Cancer Immunology and Immunotherapy)

Graft-Versus-Host Disease (GVHD) After Hematopoietic Cell Transplantation (HCT)

edited by Monzr M. Al-Malki

submission deadline 30 Sep 2025 | 1 articles | Viewed by 1609 | Submission Open

Keywords: graft-versus-host disease (GVHD); hematopoietic stem cell transplantation; risk factors

(This special issue belongs to the Section Cancer Immunology and Immunotherapy)

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