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Cancers publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Discoveries in Targeted Therapies for Melanoma: From Molecular Mechanisms to Therapeutics

edited by Georg Thomas Wondrak

submission deadline 1 Nov 2025 | 2 articles | Viewed by 4944

Keywords: malignant melanoma; cutaneous melanoma; uveal melanoma; drug resistance; targeted therapeutics; immune checkpoint inhibitors; targeted therapeutics; BRAF inhibitors; MEK inhibitors; drug discovery; molecular targets; melanoma diagnostics; precision medicine

(This special issue belongs to the Section Cancer Therapy)

Advances in Thoracic Oncology Research

edited by

Domenico Galetta

submission deadline 1 Nov 2025 | 1 articles | Viewed by 2790

Keywords: lung cancer; mediastinal; thymic; neuroendocrine; robotic; VATS; chest wall; chemotherapy; immunotherapy; radiotherapy

(This special issue belongs to the Section Cancer Therapy)

Advances in Prostate Biopsy: From Innovative Imaging Modalities to Optimized Detection Strategies

edited by

Fabio Zattoni

submission deadline 1 Nov 2025 | 1 articles | Viewed by 921

Keywords: prostate biopsy; PSMA PET; systematic biopsies; targeted biopsies; transrectal biopsies; transperineal biopsies; cost-effectiveness; perilesional biopsy; PCa detection; imaging modalities

(This special issue belongs to the Section Methods and Technologies Development)

Protein Kinases and Signal Transduction Pathways in Regulating Tumor Growth

edited by

Ralf Landgraf

submission deadline 1 Nov 2025 | 1 articles | Viewed by 654

Keywords: protein kinases; protein kinase inhibitors; protein phosphatases; inositol kinases; signal integration; kinase– lipid interaction

(This special issue belongs to the Section Cancer Biomarkers)

Targeting TGF-β as a Marker and Pharmacological Target against Cancer

edited by

Elisabetta Aldieri

submission deadline 1 Nov 2025 | Viewed by 460

Keywords: TGF-β ; cancer; tumorigenesis; metastasis; epithelial– mesenchymal transition (EMT); marker; therapy

(This special issue belongs to the Section Tumor Microenvironment)

Neuro-Immune Orchestration in Brain Tumors: From Molecular Signatures to Therapeutic Innovation

edited by

Mitsugu Fujita

, Masasuke Ohno and Shunichiro Kuramitsu

submission deadline 1 Nov 2025 | Viewed by 294

Keywords: neuro-immunology; brain tumor microenvironment; immunotherapy; molecular signatures; tumor-immune interactions

(This special issue belongs to the Section Cancer Immunology and Immunotherapy)

Novel Research on the Diagnosis and Treatment of Melanoma

edited by Roberta Giuffrida, Stefania Guida,

Caterina Dianzani

and

Claudio Conforti

submission deadline 5 Nov 2025 | 4 articles | Viewed by 7556 | Submission Open

Keywords: melanoma; diagnosis; treatment; nevi; noninvasive imaging; targeted therapy; targeted diagnosis; immunotherapy

(This special issue belongs to the Section Clinical Research of Cancer)

Advancing Hepatocellular Imaging: Innovations in Diagnosis, Prognosis, and Treatment Response Assessment

edited by

Laurent Dercle

and Fatima Zohra Mokrane

submission deadline 5 Nov 2025 | Viewed by 578 | Submission Open

Keywords: hepatocellular imaging; diagnosis; prognosis; treatment

(This special issue belongs to the Section Cancer Therapy)

Advances of Particle Therapy in Prostate Cancer—2nd Edition

edited by

Xinning Wang

submission deadline 5 Nov 2025 | Viewed by 279 | Submission Open

Keywords: prostate cancer; particle therapy; radiation therapy; diagnosis; treatment; SBRT; IMRT

(This special issue belongs to the Section Cancer Therapy)

Interventional Oncology: Advances in Cancer Care

edited by

Mina S. Makary

submission deadline 7 Nov 2025 | 1 articles | Viewed by 4824 | Submission Open

Keywords: interventional oncology; image guided; cancer care; quality of life

(This special issue belongs to the Section Methods and Technologies Development)

Advances in Medical Imaging for Cancer Detection and Diagnosis

edited by Claudia R. Mello-Thoms and Mark Anastasio

submission deadline 7 Nov 2025 | 1 articles | Viewed by 4364 | Submission Open

Keywords: photon-counting CT applications and developments; radiomics; AI and ML applications; collaborative CAD/AI; computational pathology; multimodality imaging of cancer; especially in vivo; emerging cancer imaging modalities; cancer imaging; machine learning; artificial intelligence; medical imaging

(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)

Hematological Malignancie: Progress and Challenges

edited by Lucas Coelho Arruda and Arwen Stikvoort

submission deadline 7 Nov 2025 | Viewed by 236 | Submission Open

Keywords: hematological malignancies; blood cancers; leukemia; lymphoma; multiple myeloma; immunotherapy; CAR-T-cell therapy; stem cell therapies; cell-based treatments; patient outcomes; immunoregulation; personalized medicine; molecular pathways; clinical Immunology

(This special issue belongs to the Section Cancer Therapy)

Genetics in Hematological Malignancies

edited by

Monika Lejman

submission deadline 10 Nov 2025 | 1 articles | Viewed by 1152 | Submission Open

Keywords: hematological malignancies; genomic alterations; personalized medicine; next-generation sequencing; epigenetics; biomarkers; leukemia; lymphoma; myeloma; genetic profiling

(This special issue belongs to the Section Molecular Cancer Biology)

Targeted Therapy of Pediatric Cancer (2nd Edition)

edited by

Günther H.S. Richter

submission deadline 10 Nov 2025 | Viewed by 482 | Submission Open

Keywords: leukemia; lymphoma; pediatric solid malignancies; targeted therapy; biomarker discovery; actionable mutations; drug vulnerabilities; combination therapy; immunotherapeutic approaches; preclinical studies

(This special issue belongs to the Section Pediatric Oncology)

Advances in Pleural and Peritoneal Mesothelioma

edited by

Rossella Bruno

submission deadline 10 Nov 2025 | Viewed by 256 | Submission Open

Keywords: pleural mesothelioma; peritoneal mesothelioma; differential diagnosis; biomarkers; next-generation sequencing; gene expression

(This special issue belongs to the Section Molecular Cancer Biology)

Minimally Invasive Surgery and Robotic Techniques in GI Cancer Treatment

edited by Luca Milone and Abid Qureshi

submission deadline 14 Nov 2025 | Viewed by 77 | Submission Open

Keywords: minimally invasive surgery; robotic surgery; gastrointestinal cancer; surgical oncology; laparoscopic surgery; advanced surgical technology; robotic-assisted procedures; AI in robotic surgery

(This special issue belongs to the Section Methods and Technologies Development)

Clinical Outcomes in Urologic Cancers

edited by

Simone Morra

and Pierre Karakiewicz

submission deadline 15 Nov 2025 | 19 articles | Viewed by 47003 | Submission Open

Keywords: bladder cancer; prostate cancer; kidney cancer; upper tract urothelial carcinoma; adrenocortical cancer

(This special issue belongs to the Section Clinical Research of Cancer)

Breast Cancer: Biomarkers of Diagnosis and Prognosis

edited by

Andrew R. Green

and Sarah J. Storr

submission deadline 15 Nov 2025 | 9 articles | Viewed by 18832 | Submission Open

Keywords: breast cancer; biomarker; diagnosis; prognosis

(This special issue belongs to the Section Cancer Biomarkers)

Brain Metastases: From Mechanisms to Treatment

edited by Dawen Zhao and Michael Chan

submission deadline 15 Nov 2025 | 7 articles | Viewed by 14638 | Submission Open

Keywords: brain metastasis; the tumor microenvironment; blood– tumor barrier; novel biomarkers and therapeutics; radiation therapy

(This special issue belongs to the Section Cancer Metastasis)

Benign and Malignant Neoplasms of the Head and Neck

edited by Charles C. L. Tong and Brett A. Miles

submission deadline 15 Nov 2025 | 4 articles | Viewed by 11667 | Submission Open

Keywords: laryngeal cancer; oral cavity and oropharynx cancer; nasal cavity and paransal sinus cancer; anterior and lateral skull base cancer; salivary gland cancer; melanoma

(This special issue belongs to the Section Cancer Therapy)

Immune-Related Adverse Events in Cancer Immunotherapy

edited by Kate Young and Anna Olsson-Brown

submission deadline 15 Nov 2025 | 4 articles | Viewed by 11203 | Submission Open

Keywords: check point inhibitors (CPIs); immunotherapy; irAEs; immune checkpoint inhibitors (ICIs); survivorship; long-term toxicity; steroid refractory; biologics; CAR-T; TILs

(This special issue belongs to the Section Cancer Immunology and Immunotherapy)

Overcoming Pitfalls in the Detection and Definition of Clinically Significant Prostate Cancer: Strategies to Improve Screening and Diagnosis

edited by

Fabio Zattoni

submission deadline 15 Nov 2025 | 2 articles | Viewed by 5612 | Submission Open

Keywords: prostate cancer; PSA; magnetic resonance of the prostate; prostatic tissue-based biomarkers; prostate biopsy; prostate cancer screening

(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)

Radiotherapy for Thoracic Malignancies: New Advances and Challenges: 2nd Edition

edited by

Eric C. Ko

submission deadline 15 Nov 2025 | 3 articles | Viewed by 4293 | Submission Open

Keywords: radiotherapy; stereotactic body radiation therapy; non-small cell lung cancer; immunotherapy; thoracic oncology

(This special issue belongs to the Section Cancer Therapy)

Advances in Therapeutic Approaches Targeting Pediatric and Adult Glioma

edited by Siddhartha Mitra and

Senthilnath Lakshmanachetty

submission deadline 15 Nov 2025 | 1 articles | Viewed by 3498 | Submission Open

Keywords: glioma; high-grade glioma; glioblastoma; DIPG; ependymoma; immunotherapy; targeted therapy; combination therapies; small-molecule inhibitors

(This special issue belongs to the Section Cancer Therapy)

Advances in Radiomic, Genomic and Radiogenomic Techniques in Pediatric Medulloblastoma

edited by Marwa Ismail

submission deadline 15 Nov 2025 | 1 articles | Viewed by 2654 | Submission Open

Keywords: medulloblastoma; pediatrics; radiomics; genomics; segmentation; deep learning; classification; risk-stratification; molecular subgroups

(This special issue belongs to the Section Cancer Therapy)

Recent Advances in Trachea, Bronchus and Lung Cancer Management: 2nd Edition

edited by

Serafeim Chrysovalantis Kotoulas

, Dionisios G. Spyratos and

Athanasia Pataka

submission deadline 15 Nov 2025 | 1 articles | Viewed by 938 | Submission Open

Keywords: trachea; bronchus and lung cancer; non-small cell lung cancer (NSCLC); small cell lung cancer (SCLC); cancer management; clinical suspicion; diagnosis; treatment; prevention

(This special issue belongs to the Section Cancer Epidemiology and Prevention)

Nanomedicine and Nanobiotechnology in Cancer

edited by

Anne-Marie Caminade

submission deadline 15 Nov 2025 | Viewed by 608 | Submission Open

Keywords: nanomedicine; nanobiotechnology; nanodevices; nanoimaging; 3D models; drug delivery; nanotechnologies for translational medicine; pre-clinical and clinical phases; from bench to bedside

(This special issue belongs to the Section Methods and Technologies Development)

New Advances in the Treatment of Pediatric Solid Tumors

edited by

Myriam Weyl Ben-Arush

and Oz Mordechai

submission deadline 20 Nov 2025 | 3 articles | Viewed by 6912 | Submission Open

Keywords: pediatric oncology; solid tumors; precision medicine; immunotherapy; artificial intelligence; innovative therapies

(This special issue belongs to the Section Pediatric Oncology)

Cancer Treatment: Present and Future of Radioligand Therapy

edited by

Egesta Lopci

and

Akram N. Al-Ibraheem

submission deadline 20 Nov 2025 | 2 articles | Viewed by 5751 | Submission Open

Keywords: radioligand therapy; PRLT; FAPI; PSMA; CXCR4; GRPR; GLP-1R; RLT; novel radiopharmaceutical; cancer theranostics

(This special issue belongs to the Section Cancer Therapy)

Thyroid Cancer: New Advances from Diagnosis to Therapy: 2nd Edition

edited by

Michael Kreißl

submission deadline 20 Nov 2025 | 5 articles | Viewed by 5217 | Submission Open

Keywords: thyroid scintigraphy; thyroid nodules; thyroid cancer; multikinase inhibitors; precision oncology; radioiodine

(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)

Existing and Emerging Biomarkers for Immune Checkpoint Immunotherapy in Solid Tumors (2nd Edition)

edited by Nuria Romero-Laorden

submission deadline 20 Nov 2025 | 2 articles | Viewed by 4187 | Submission Open

Keywords: immunotherapy; checkpoint inhibitors; biomarkers; immune biomarkers; PD-L1; TMB; solid tumors

(This special issue belongs to the Section Cancer Immunology and Immunotherapy)

Improving the Quality of Life in Patients with Gynecological Cancer

edited by Vasilios Pergialiotis

submission deadline 20 Nov 2025 | 1 articles | Viewed by 2651 | Submission Open

Keywords: gynecologic oncology; minimal invasive surgery; ovarian cancer; ERAS protocol; perioperative care; immunonutrition; cervical cancer

(This special issue belongs to the Section Cancer Survivorship and Quality of Life)

Aberrant Cytokine Receptor Signaling in Hematological Cancers and Proliferative Disorders

edited by

Alister C. Ward

submission deadline 20 Nov 2025 | 1 articles | Viewed by 915 | Submission Open

Keywords: cytokine receptor; signaling; leukemia; lymphoma; myeloproliferative neoplasm; hematology; oncology

(This special issue belongs to the Section Tumor Microenvironment)

Salivary and Tissue Biomarkers in Head and Neck Cancers: Diagnostic and Prognostic Role

edited by

Eugenia Allegra

and

Maria Rita Bianco

submission deadline 20 Nov 2025 | Viewed by 190 | Submission Open

Keywords: head and neck cancer; biomarker; early diagnosis and prognosis

(This special issue belongs to the Section Cancer Biomarkers)

The Pathologic Diagnosis and Clinical Therapy of Neuroendocrine Tumors: 2nd Edition

edited by

Salvatore Tafuto

Ottavia Clemente

and

Annabella Di Mauro

submission deadline 20 Nov 2025 | Viewed by 8 | Submission Open

Keywords: neuroendocrine neoplasms; molecular mechanisms; cancer pathogenesis; tumorigenesis; diagnosis; molecular and cellular heterogeneity; predictive biomarkers; animal models and of neuroendocrine cancer; diagnostic clinical oncology; genomic characterization; clinical biomarkers; biomarkers of drug response; epigenetic biomarkers; targeted therapy; tumor immunity; molecular oncology; clinical therapy

Epigenetic and Metabolic Alterations in the Tumor Microenvironment: 2nd Edition

edited by

Ciro Isidoro

and

Danny N. Dhanasekaran

submission deadline 21 Nov 2025 | 1 articles | Viewed by 2187 | Submission Open

Keywords: tumor microenvironment; hypoxia; inflammation; cytokines; epigenetics; metabolic cross-talk; cancer stroma cells; epigenetic alterations; cancer cell dormancy; cancer cell proliferation; cancer cell migration; cancer cell stemness

(This special issue belongs to the Section Tumor Microenvironment)

Quality of Life in Patients with Brain Tumors

edited by Priya U. Kumthekar, Akanksha Sharma and Margaret Johnson

submission deadline 23 Nov 2025 | 1 articles | Viewed by 1599 | Submission Open

Keywords: quality of life; palliative care; patient reported outcomes; survivorship; caregiver distress; symptom management

(This special issue belongs to the Section Cancer Survivorship and Quality of Life)

Advances in Molecular Mechanisms of Gastrointestinal Tumors (2nd Edition)

edited by

Shihori Tanabe

submission deadline 25 Nov 2025 | 3 articles | Viewed by 3173 | Submission Open

Keywords: molecular mechanism; gastrointestinal tumor; gastric cancer; colorectal cancer; esophageal cancer; tumor microenvironment; molecular network; molecular pathway; pathway network; signal transduction

(This special issue belongs to the Section Molecular Cancer Biology)

Clinical Trials of Sarcoma

edited by Patrick Schlegel

submission deadline 25 Nov 2025 | 1 articles | Viewed by 1903 | Submission Open

Keywords: cancer; sarcoma; clinical trial

Neurosurgical Advances in Brain Tumor Surgery

edited by Camilla Bonaudo, Alessandro Della Puppa and

Antonello Grippo

submission deadline 28 Nov 2025 | 2 articles | Viewed by 2970 | Submission Open

Keywords: brain lesions/tumors; preoperative mapping; neuro-oncology; navigated TMS (n TMS); brain stimulation; optical imaging; cognitive mapping; awake surgery; functional mapping; functional preservation; intraoperative monitoring; neurophysiological monitoring

(This special issue belongs to the Section Clinical Research of Cancer)

Advances in Brachytherapy in the Treatment of Tumors

edited by

Hideya Yamazaki

submission deadline 30 Nov 2025 | 12 articles | Viewed by 34340 | Submission Open

Keywords: brachytherapy; LDR; HDR; PDR; cervical cancer; prostate cancer; breast cancer

(This special issue belongs to the Section Cancer Therapy)

Novel Therapeutic Approaches for Cancer Treatment

edited by

Marzia Bruna Gariboldi

submission deadline 30 Nov 2025 | 13 articles | Viewed by 31279 | Submission Open

Keywords: cancer; small molecules; epigenetic drugs; drug delivery system; targeted therapy; personalized medicine; photodynamic therapy; photothermal therapy; sonodynamic therapy; drug repurposing; combination therapy

(This special issue belongs to the Section Cancer Therapy)

Radiomics and Imaging in Cancer Analysis

edited by

Marco Bertolini

and

Lidia Strigari

submission deadline 30 Nov 2025 | 13 articles | Viewed by 24117 | Submission Open

Keywords: radiomics; biomarker; cancer imaging; machine learning; oncology

(This special issue belongs to the Section Methods and Technologies Development)

Immunotherapy in the Management of Hematologic Malignancy

edited by Mohammad S. Hossain

submission deadline 30 Nov 2025 | 6 articles | Viewed by 22255 | Submission Open

Keywords: allo/auto HSCT; GvHD; immunotherapy; viral infection; hematologic malignancy

(This special issue belongs to the Section Cancer Immunology and Immunotherapy)

Recent Advances in Skin Cancers

edited by

Syril Keena T. Que

submission deadline 30 Nov 2025 | 2 articles | Viewed by 18713 | Submission Open

Keywords: cutaneous squamous cell carcinoma; staging; surgical treatment; immunotherapy; cemiplimab; adjuvant radiation; gene expression profile; Brigham and Women’ s Hospital tumor staging system; American Joint Committee on Cancer staging system

(This special issue belongs to the Section Cancer Therapy)

Sarcoma: Clinical Trials and Management

edited by

Mohammed M. Milhem

and

John Rieth

submission deadline 30 Nov 2025 | 6 articles | Viewed by 13120 | Submission Open

Keywords: soft tissue sarcoma; bone sarcoma; chemotherapy; immunotherapy; targeted therapy; radiotherapy; pediatric sarcoma; adult sarcoma

(This special issue belongs to the Section Clinical Research of Cancer)

New Approaches in the Treatment of Hepatocellular Carcinoma and Liver Tumor

edited by Riccardo Inchingolo, Stavros Spiliopoulos and Riccardo Memeo

submission deadline 30 Nov 2025 | 10 articles | Viewed by 12285 | Submission Open

Keywords: hepatocellular carcinoma; cirrhosis; liver; interventional oncology; trans-arterial chemo embolization; selective internal radiation therapy; ablation; radiology

(This special issue belongs to the Section Cancer Therapy)

Advancements in Surgical Approaches for Gynecological Cancers

edited by

Anna Myriam Perrone

and

Camelia Alexandra Coada

submission deadline 30 Nov 2025 | 9 articles | Viewed by 12057 | Submission Open

Keywords: gynecological cancers; minimally invasive surgery; advancements in oncological treatments; challenges; survival outcomes; complete surgical resection; management; cytoreduction; negative surgical margins

(This special issue belongs to the Section Cancer Therapy)

The New Challenge of Curing AML: Analysis of Mechanisms of Resistance of Target Drugs and Future Perspectives

edited by

Debora Capelli

submission deadline 30 Nov 2025 | 4 articles | Viewed by 11447 | Submission Open

Keywords: AML; FLT3 inhibitors; BCL2 inhibitor; MCL1; IDH1-2 inhibitors; venetoclax; CAR-T; anti-CD123 monoclonal antibodies; anti-CD33 monoclonal antibodies; anti-PD-1 and -PD-L1

(This special issue belongs to the Section Tumor Microenvironment)

Immune Landscape of Renal Cell Carcinoma

edited by

Scott S. Tykodi

and Yuexin Xu

submission deadline 30 Nov 2025 | 4 articles | Viewed by 10319 | Submission Open

Keywords: renal cell carcinoma; solid tumor; immunotherapy; immune checkpoint inhibitor; T cell; tumor microenvironment; biomarkers; tumor antigen; immune surveillance

(This special issue belongs to the Section Cancer Immunology and Immunotherapy)

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