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Cancers publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Towards a Personalized Medicine for the Diagnosis and Management of Gynecological Cancers
edited by and Gabriele Centini
submission deadline 30 Jan 2026 | 3 articles | Viewed by 22598 | Submission Open
(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)
The Advance of Pencil Beam Scanning Proton Beam Therapy in Cancers
edited by , Richard A. Amos and Heng Li
submission deadline 30 Jan 2026 | 7 articles | Viewed by 17136 | Submission Open
Keywords: proton therapy; pencil beam scanning; robustness; adaptive radiotherapy; imaging guidance; radiobiological model; FLASH radiotherapy; spatially fractionated radiotherapy (SFRT); proton arc
(This special issue belongs to the Section Cancer Therapy)
Cancer Disparities: Biological, Social, and Environmental Determinants submission deadline 30 Jan 2026 | 3 articles | Viewed by 7829 | Submission Open
Keywords: cancer epidemiology; cancer etiology; environmental factors; screening and diagnostics; SDGs
(This special issue belongs to the Section Cancer Epidemiology and Prevention)
Advances in the Treatment of Upper Gastrointestinal Cancer
edited by Sang-ho Jeong and
submission deadline 30 Jan 2026 | 2 articles | Viewed by 6101 | Submission Open
Keywords: upper gastrointestinal cancer; surgery therapy; chemotherapy therapy; radiation therapy
(This special issue belongs to the Section Cancer Therapy)
Protein Structure and Cancer—2nd Edition submission deadline 30 Jan 2026 | Viewed by 264 | Submission Open
Keywords: protein structure dynamics; structural cancer biology; protein pathways in cancer; structure– function alterations; in silico protein structure prediction; protein interactions; cancer mutations and protein structure alterations
(This special issue belongs to the Section Molecular Cancer Biology)
Advances in Drug Delivery for Cancer Therapy submission deadline 31 Jan 2026 | 9 articles | Viewed by 45871 | Submission Open
Keywords: cancer; oncology; therapeutic target; drug resistance; immunotherapy; chemotherapy; small molecule inhibitors; drug delivery; nanoparticle
(This special issue belongs to the Section Cancer Drug Development)
How COVID-19 Affects Cancer Patients
edited by
submission deadline 31 Jan 2026 | 15 articles | Viewed by 37940 | Submission Open
Keywords: COVID-19; pandemic; cancer; impact; incidence; mortality; lethality; disparities; gender
(This special issue belongs to the Section Cancer Epidemiology and Prevention)
Surgical Advances in Cancer Treatments: Exploring Innovative Approaches and Emerging Perspectives submission deadline 31 Jan 2026 | 17 articles | Viewed by 37178 | Submission Open
Keywords: surgical oncology; surgical innovation; image-guided surgery; robotic-assisted surgery; multidisciplinary oncology; surgical outcomes research; precision surgery; healthcare economics; surgical training and simulation
(This special issue belongs to the Section Cancer Therapy)
Genetics and Epigenetics of Gynecological Cancer
edited by
submission deadline 31 Jan 2026 | 10 articles | Viewed by 33278 | Submission Open
Keywords: gynecologic cancers; epigenetics; genetics; immunogenetics; predisposing mutations; biomarkers; targeted therapies; chemoresistance
(This special issue belongs to the Section Cancer Pathophysiology)
CAR T Cells in Lymphoma and Multiple Myeloma submission deadline 31 Jan 2026 | 7 articles | Viewed by 29351 | Submission Open
Keywords: multiple myeloma; lymphoma; CAR T therapy; bi-specific antibodies; cellular therapy
(This special issue belongs to the Section Cancer Immunology and Immunotherapy)
Screening, Early Detection and Prevention of Hepato-Pancreato-Biliary (HPB) Cancers
edited by Zaed Z.R. Hamady
submission deadline 31 Jan 2026 | 7 articles | Viewed by 26989 | Submission Open
Keywords: hepatobiliary cancer; pancreatic cancer; early detection; diagnosis; screening; prevention
(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)
Thyroid Cancer: Diagnosis, Prognosis and Treatment (2nd Edition) submission deadline 31 Jan 2026 | 9 articles | Viewed by 20746 | Submission Open
Keywords: thyroid cancer; ultrasound; molecular imaging; fine-needle aspiration cytology; thyroidectomy; radioactive iodine; radioiodine-refractory thyroid cancer; tyrosine kinase inhibitors
(This special issue belongs to the Section Cancer Therapy)
Empowering Cancer Survivors: A Comprehensive Approach to Supportive Care Through Pharmacological and Non-Pharmacological Approaches Including Exercise, Physical Activity and Nutrition
edited by Kellie Toohey
submission deadline 31 Jan 2026 | 11 articles | Viewed by 17980 | Submission Open
Keywords: cancer; physical activity; exercise; supportive care; holistic care; rehabilitation
(This special issue belongs to the Section Cancer Survivorship and Quality of Life)
Pathology and Treatment of Triple-Negative Breast Cancer
edited by
submission deadline 31 Jan 2026 | 4 articles | Viewed by 13340 | Submission Open
(This special issue belongs to the Section Cancer Pathophysiology)
Implementation of Physical Activity Promotion in Cancer Care
edited by Sarah Hardcastle
submission deadline 31 Jan 2026 | 4 articles | Viewed by 11309 | Submission Open
Keywords: physical activity; cancer survivors; behaviour change; interventions; cancer care; implementation; health
(This special issue belongs to the Section Cancer Survivorship and Quality of Life)
Gynecological Cancer: Prevention, Diagnosis, Prognosis and Treatment
edited by Joanna P. Kacperczyk-Bartnik, Tibor Andrea Zwimpfer and
submission deadline 31 Jan 2026 | 8 articles | Viewed by 10368 | Submission Open
Keywords: gynecological cancer; ovarian cancer; cervical cancer; endometrial cancer; early diagnosis; cancer prevention; prognosis; molecular mechanisms; personalized medicine; novel therapies
(This special issue belongs to the Section Clinical Research of Cancer)
Recent Advances and Challenges in Breast Cancer Surgery: 2nd Edition submission deadline 31 Jan 2026 | 6 articles | Viewed by 10128 | Submission Open
Keywords: breast cancer surgery; axillary management; sentinel node oncoplastic surgery; reconstructive surgery; surgical technology; cancer risk reduction surgery; radio-guided surgery
(This special issue belongs to the Section Cancer Therapy)
Biomarkers and Targeted Therapy in Malignant Pleural Mesothelioma
edited by
submission deadline 31 Jan 2026 | 4 articles | Viewed by 8623 | Submission Open
Keywords: malignant mesothelioma; target therapy; biomarkers
(This special issue belongs to the Section Cancer Biomarkers)
Recent Advances in Oncology Imaging: 2nd Edition
edited by and
submission deadline 31 Jan 2026 | 4 articles | Viewed by 8582 | Submission Open
Keywords: medical imaging; cancer; oncology; molecular imaging; theragnostics
(This special issue belongs to the Section Methods and Technologies Development)
Cancer Screening and Primary Care
edited by Marievelisse Soto-Salgado
submission deadline 31 Jan 2026 | 6 articles | Viewed by 7788 | Submission Open
Keywords: screening amenable cancers; screening; primary care; disparities in cancer care; cancer outcomes
(This special issue belongs to the Section Cancer Epidemiology and Prevention)
Exploring Skin Cancer: Insights into New Diagnostic, Prognostic, and Therapeutic Strategies
edited by
submission deadline 31 Jan 2026 | 5 articles | Viewed by 7551 | Submission Open
Keywords: melanoma; non-melanoma skin cancer; NMSC; Merkel cell carcinoma; tumor microenvironment; prognosis; treatment
Advances in the Use of PET/CT and MRI in Prostate Cancer
edited by Carmelo Caldarella
submission deadline 31 Jan 2026 | 3 articles | Viewed by 5827 | Submission Open
Keywords: PET/CT; MRI; prostate cancer; radiomic; receptor-targeted radiopharmaceuticals
(This special issue belongs to the Section Methods and Technologies Development)
The Role of Apoptosis and Autophagy in Cancer
edited by
submission deadline 31 Jan 2026 | 3 articles | Viewed by 5548 | Submission Open
Keywords: apoptosis; cell death; tumor
(This special issue belongs to the Section Molecular Cancer Biology)
Clinical Studies and Outcomes in Urologic Cancer
edited by Nikolaos Pyrgidis
submission deadline 31 Jan 2026 | 5 articles | Viewed by 5481 | Submission Open
Keywords: urologic cancer; clinical outcomes; prostate cancer; urothelial cancer; kidney cancer; survival analysis; treatment response; quality of life; novel therapies; oncology
(This special issue belongs to the Section Clinical Research of Cancer)
Prediction of Melanoma
edited by
submission deadline 31 Jan 2026 | 3 articles | Viewed by 4481 | Submission Open
Keywords: melanoma; melanoma genetics; biomarkers; predictive tools; risk prediction; risk factors; artificial intelligence
(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)
Post-Neoadjuvant Strategies in Breast Cancer (2nd Edition)
edited by , Tanja Fehm and
submission deadline 31 Jan 2026 | 1 articles | Viewed by 3967 | Submission Open
Keywords: chemotherapy; prospective trials; clinical investigation; breast tumor; local recurrence; overall survival
(This special issue belongs to the Section Cancer Therapy)
Minimally Invasive Approaches in Urological Oncology: Current Trends and Innovations submission deadline 31 Jan 2026 | 4 articles | Viewed by 3726 | Submission Open
Keywords: minimally invasive; robotic; laparoscopic; uro-oncology; prostate cancer; bladder cancer; kidney cancer; testicular cancers; quality of life; penile cancer
(This special issue belongs to the Section Clinical Research of Cancer)
Recent Advances in Nanomedicine-Based Cancer Immunotherapy
edited by Navin Kumar Verma, and
submission deadline 31 Jan 2026 | 1 articles | Viewed by 2991 | Submission Open
Keywords: cancer nano-therapy; nano-enabled therapeutic; immune checkpoint inhibitors; tumor immunosuppression; adoptive cell therapy; CAR T-cell therapy; tumor-infiltrating lymphocyte therapy; monoclonal antibody therapy for cancer; cancer vaccines; immune system modulators
(This special issue belongs to the Section Cancer Immunology and Immunotherapy)
Computational Research in Cancer Neuroscience
edited by Shaolei Teng
submission deadline 31 Jan 2026 | 1 articles | Viewed by 2972 | Submission Open
Keywords: machine learning; large language models; protein structure modeling; omics data analysis; neural– cancer communication; tumor microenvironments; personalized medicine; targeted therapies; cancer neuroscience
(This special issue belongs to the Section Methods and Technologies Development)
Novel Perspectives in Hepato-Biliary and Pancreatic Cancer
edited by Tudor Mocan and Emil-Ioan Moiș
submission deadline 31 Jan 2026 | 2 articles | Viewed by 2970 | Submission Open
Keywords: HCC; cholangiocarcinoma; surgery; biliary drainage; pancreatic cancer; combination therapies
(This special issue belongs to the Section Cancer Therapy)
Advances and Future Developments in Liver Transplantation for Cancers: 2nd Edition
edited by
submission deadline 31 Jan 2026 | 2 articles | Viewed by 2833 | Submission Open
Keywords: machine perfusion; marginal graft; split liver; immunotherapy; auxiliary liver transplantation; digital twin; modeling; organoid
(This special issue belongs to the Section Transplant Oncology)
Cancers Hijack Immune Surveillance and Tumor Microenvironment Leading to Immune Evasion
edited by , Viktor Umansky and
submission deadline 31 Jan 2026 | 1 articles | Viewed by 2677 | Submission Open
Keywords: anti-tumor immunity; cancer immunotherapy; immune evasion; immune response modulation; immunosuppression; immune surveillance; manipulating IR components function and migration; metabolic modulation of the TME; metabolic reprogramming; tumor-associated immune cells; tumor microenvironment (TME)
(This special issue belongs to the Section Cancer Immunology and Immunotherapy)
Head and Neck Cancer: Survivorship Challenges and Therapeutic Approaches
edited by , Avraham Eisbruch and
submission deadline 31 Jan 2026 | 1 articles | Viewed by 2161 | Submission Open
Keywords: head and neck cancer; supportive care; survivorship care; physiotherapy; quality of life; lifestyle interventions
(This special issue belongs to the Section Cancer Therapy)
Radiosensitivity and Radiotoxicity in Cancer submission deadline 31 Jan 2026 | 1 articles | Viewed by 2008 | Submission Open
Keywords: radiation therapy; clinical outcome; radiosensitivity; radiotoxicity; biomarkers; bioinformatics; systems biology
(This special issue belongs to the Section Methods and Technologies Development)
Advanced Strategies in the Care of Hepatocellular Carcinoma Patients (2nd Edition) submission deadline 31 Jan 2026 | 1 articles | Viewed by 1681 | Submission Open
Keywords: hepatocellular carcinoma; hepatic resection; hepatectomy; liver resection; liver surgery; parenchymal-sparing liver surgery; intraoperative ultrasound; liver-specific magnetic resonance imaging; trans-arterial therapy; liver function; FibroScan
(This special issue belongs to the Section Cancer Survivorship and Quality of Life)
Advanced Glycation End-Products and Its Receptors in Cancer Progression
edited by Bhaumik B. Patel
submission deadline 31 Jan 2026 | 1 articles | Viewed by 1557 | Submission Open
Keywords: advanced glycation end products; toxic advanced glycation end products; receptor for advanced glycation end products (RAGEs); glycosaminoglycans; cancer; cancer stem cells (CSCs); tumor immune microenvironment (TME)
(This special issue belongs to the Section Tumor Microenvironment)
Emerging Technologies in Thoracic Surgery
edited by Filippo Lococo and
submission deadline 31 Jan 2026 | 1 articles | Viewed by 1413 | Submission Open
Keywords: lung cancer; molecular biology; liquid biopsy; immunotherapy; precision surgery; minimally invasive surgery; new technologies; artificial intelligence
(This special issue belongs to the Section Methods and Technologies Development)
New Insights into Pheochromocytoma and Paraganglioma
edited by
submission deadline 31 Jan 2026 | 2 articles | Viewed by 1247 | Submission Open
Keywords: pheochromocytoma; paraganglioma; diagnosis; genetics; imaging; long-term follow-up; standards
(This special issue belongs to the Section Clinical Research of Cancer)
The Biology of Hepatocellular Carcinoma: Implications for Genomic and Immune Therapies (2nd Edition)
edited by
submission deadline 31 Jan 2026 | 1 articles | Viewed by 915 | Submission Open
Keywords: hepatocellular carcinoma; diagnosis; treatment; molecular targeted agent; immune checkpoint inhibitor; artificial intelligence
(This special issue belongs to the Section Molecular Cancer Biology)
New Insights in Nanomedicine and Targeted Drugs for Breast Cancer
edited by , Gennaro Sanità, Alessandro Venuta and Rosarita Nasso
submission deadline 31 Jan 2026 | Viewed by 499 | Submission Open
Keywords: breast cancer; nanoparticles; active targeting; BC; nanomedicine
(This special issue belongs to the Section Cancer Drug Development)
The Cancer Stem Cells and the Quiescence
edited by
submission deadline 31 Jan 2026 | Viewed by 448 | Submission Open
Keywords: cancer stem cells; new markers; organoid cultures; cancer cell dormancy and quiescence; metastasis; animal models; metabolism; drug resistance
(This special issue belongs to the Section Molecular Cancer Biology)
Lymph Node Involvement in Cervical Cancer: From Single Isolated Tumor Cell to Macrometastasis
edited by , and Thomas Gaillard
submission deadline 31 Jan 2026 | Viewed by 401 | Submission Open
Keywords: cervical cancer; lymph nodes; metastasis; isolated Tumor Cells; sentinel lymph node; non-sentinel lymph node; tumor-draining lymph nodes; microenvironment; one-step nucleic acid amplification; imaging
(This special issue belongs to the Section Tumor Microenvironment)
Diagnosis and Biomarkers for Hematologic Malignancies submission deadline 31 Jan 2026 | Viewed by 260 | Submission Open
Keywords: hematologic malignancies; diagnosis; biomarkers
(This special issue belongs to the Section Cancer Biomarkers)
Recent Advances in the Molecular Biology of Urologic Cancers: Integrative Insights from Pathogenesis to Clinical Applications
edited by
submission deadline 31 Jan 2026 | 1 articles | Viewed by 252 | Submission Open
Keywords: urologic cancers; molecular biology; pathogenesis; precision medicine; biomarkers; multi-omics; targeted therapies; immunotherapy; translational research; clinical applications
(This special issue belongs to the Section Molecular Cancer Biology)
Transformative Drug Innovations Reshaping Myeloma Treatment
edited by Despina Fotiou
submission deadline 31 Jan 2026 | Viewed by 184 | Submission Open
Keywords: multiple myeloma; cellular therapy; immunotherapy
(This special issue belongs to the Section Cancer Therapy)
Conversion Surgery for Initially Unresectable, Locally Advanced, Metastatic or Recurrent Gastrointestinal Cancers
edited by
submission deadline 31 Jan 2026 | Viewed by 179 | Submission Open
Keywords: conversion surgery; locally advanced disease; metastatic disease; chemotherapy; radiotherapy; immunotherapy; heptobiliary-pancreatic cancers; gastrointestinal tract cancers
(This special issue belongs to the Section Clinical Research of Cancer)
Immune Profiling in Gastrointestinal Cancers: Implications for Precision Immunotherapy
edited by
submission deadline 31 Jan 2026 | Viewed by 166 | Submission Open
Keywords: gastrointestinal cancer; immune profiling; immunocompetent cells; personalized immunotherapy; biomarkers; precision medicine; tumor microenvironment; tumor-infiltrating lymphocytes; immune checkpoint inhibitors; microbiota– immunity interactions; single-cell analysis; spatial transcriptomics
(This special issue belongs to the Section Cancer Immunology and Immunotherapy)
Personalized Cancer Therapy: Strategies for Overcoming On-Target and Bypass Resistance
edited by
submission deadline 31 Jan 2026 | Viewed by 129 | Submission Open
Keywords: resistance mechanisms; biomarker; oncogene dependency; target therapy; personalized therapy
(This special issue belongs to the Section Molecular Cancer Biology)
Advances in Thoracic Oncology Research
edited by
submission deadline 1 Feb 2026 | 2 articles | Viewed by 3230 | Submission Open
Keywords: lung cancer; mediastinal; thymic; neuroendocrine; robotic; VATS; chest wall; chemotherapy; immunotherapy; radiotherapy
(This special issue belongs to the Section Cancer Therapy)
Therapy for HER2 Breast Cancer
edited by and Sandra M. Swain
submission deadline 1 Feb 2026 | Viewed by 208 | Submission Open
Keywords: antibody– drug conjugate; trastuzumab; pertuzumab; tyrosine kinase inhibitor; trastuzumab deruxtecan
(This special issue belongs to the Section Cancer Therapy)
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