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Cancers publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Advances in Molecular Mechanisms of Gastrointestinal Tumors (2nd Edition)

edited by

Shihori Tanabe

submission deadline 25 Nov 2025 | 4 articles | Viewed by 4164 | Submission Open

Keywords: molecular mechanism; gastrointestinal tumor; gastric cancer; colorectal cancer; esophageal cancer; tumor microenvironment; molecular network; molecular pathway; pathway network; signal transduction

(This special issue belongs to the Section Molecular Cancer Biology)

Clinical Trials of Sarcoma

edited by Patrick Schlegel

submission deadline 25 Nov 2025 | 1 articles | Viewed by 2074 | Submission Open

Keywords: cancer; sarcoma; clinical trial

Advances in Brachytherapy in the Treatment of Tumors

edited by

Hideya Yamazaki

submission deadline 30 Nov 2025 | 12 articles | Viewed by 36268 | Submission Open

Keywords: brachytherapy; LDR; HDR; PDR; cervical cancer; prostate cancer; breast cancer

(This special issue belongs to the Section Cancer Therapy)

Novel Therapeutic Approaches for Cancer Treatment

edited by

Marzia Bruna Gariboldi

submission deadline 30 Nov 2025 | 13 articles | Viewed by 34811 | Submission Open

Keywords: cancer; small molecules; epigenetic drugs; drug delivery system; targeted therapy; personalized medicine; photodynamic therapy; photothermal therapy; sonodynamic therapy; drug repurposing; combination therapy

(This special issue belongs to the Section Cancer Therapy)

Radiomics and Imaging in Cancer Analysis

edited by

Marco Bertolini

and

Lidia Strigari

submission deadline 30 Nov 2025 | 13 articles | Viewed by 27016 | Submission Open

Keywords: radiomics; biomarker; cancer imaging; machine learning; oncology

(This special issue belongs to the Section Methods and Technologies Development)

Immunotherapy in the Management of Hematologic Malignancy

edited by Mohammad S. Hossain

submission deadline 30 Nov 2025 | 6 articles | Viewed by 22825 | Submission Open

Keywords: allo/auto HSCT; GvHD; immunotherapy; viral infection; hematologic malignancy

(This special issue belongs to the Section Cancer Immunology and Immunotherapy)

Recent Advances in Skin Cancers

edited by

Syril Keena T. Que

submission deadline 30 Nov 2025 | 2 articles | Viewed by 20124 | Submission Open

Keywords: cutaneous squamous cell carcinoma; staging; surgical treatment; immunotherapy; cemiplimab; adjuvant radiation; gene expression profile; Brigham and Women’ s Hospital tumor staging system; American Joint Committee on Cancer staging system

(This special issue belongs to the Section Cancer Therapy)

New Approaches in the Treatment of Hepatocellular Carcinoma and Liver Tumor

edited by Riccardo Inchingolo, Stavros Spiliopoulos and Riccardo Memeo

submission deadline 30 Nov 2025 | 11 articles | Viewed by 15188 | Submission Open

Keywords: hepatocellular carcinoma; cirrhosis; liver; interventional oncology; trans-arterial chemo embolization; selective internal radiation therapy; ablation; radiology

(This special issue belongs to the Section Cancer Therapy)

Sarcoma: Clinical Trials and Management

edited by

Mohammed M. Milhem

and

John Rieth

submission deadline 30 Nov 2025 | 6 articles | Viewed by 14271 | Submission Open

Keywords: soft tissue sarcoma; bone sarcoma; chemotherapy; immunotherapy; targeted therapy; radiotherapy; pediatric sarcoma; adult sarcoma

(This special issue belongs to the Section Clinical Research of Cancer)

Advancements in Surgical Approaches for Gynecological Cancers

edited by

Anna Myriam Perrone

and

Camelia Alexandra Coada

submission deadline 30 Nov 2025 | 10 articles | Viewed by 13644 | Submission Open

Keywords: gynecological cancers; minimally invasive surgery; advancements in oncological treatments; challenges; survival outcomes; complete surgical resection; management; cytoreduction; negative surgical margins

(This special issue belongs to the Section Cancer Therapy)

The New Challenge of Curing AML: Analysis of Mechanisms of Resistance of Target Drugs and Future Perspectives

edited by

Debora Capelli

submission deadline 30 Nov 2025 | 4 articles | Viewed by 12113 | Submission Open

Keywords: AML; FLT3 inhibitors; BCL2 inhibitor; MCL1; IDH1-2 inhibitors; venetoclax; CAR-T; anti-CD123 monoclonal antibodies; anti-CD33 monoclonal antibodies; anti-PD-1 and -PD-L1

(This special issue belongs to the Section Tumor Microenvironment)

Targeted Therapies in Pancreatic Cancer—Current Landscape and Future Directions

edited by Yongwoo Dave Seo

submission deadline 30 Nov 2025 | 3 articles | Viewed by 11742 | Submission Open

Keywords: pancreatic cancer; precision oncology; targeted therapies; immunotherapy; KRAS inhibitors; novel clinical trial design

(This special issue belongs to the Section Cancer Therapy)

Advances in Esophageal Cancer Treatment

edited by

B.P.L. (Bas) Wijnhoven

Richard Skipworth

, Pieter Van der Sluis and

Tania Triantafyllou

submission deadline 30 Nov 2025 | 3 articles | Viewed by 10683 | Submission Open

Keywords: gastric cancer; esophageal cancer; esophagectomy; chemotherapy; radiotherapy; immunotherapy; perioperative management; artificial intelligence

(This special issue belongs to the Section Cancer Therapy)

Novel Advances in Surgery for Prostate Cancer

edited by

Vincenzo De Marco

submission deadline 30 Nov 2025 | 3 articles | Viewed by 10003 | Submission Open

Keywords: prostate cancer; radical prostatectomy; robot-assisted surgery; robotic platform; technology; single port; alternative approaches; focal therapy

(This special issue belongs to the Section Clinical Research of Cancer)

Research on Fluorescence-Guided Surgery in Cancer Treatment

edited by

Julius Höhne

submission deadline 30 Nov 2025 | 4 articles | Viewed by 9827 | Submission Open

Keywords: fluorescence-guided surgery; fluorescent agents; tumor fluorescence; tumor margin detection; residual tumor assessment; glioma surgery; fluorescein sodium; 5-aminolevulinic acid; confocal endomicroscopy; Raman spectroscopy

(This special issue belongs to the Section Cancer Therapy)

Cell Therapy in Solid Cancers: Current and Future Landscape

edited by Wenwee Ma, Jan Joseph Melenhorst and Li Yin

submission deadline 30 Nov 2025 | 2 articles | Viewed by 9094 | Submission Open

Keywords: cell therapy; solid tumors; immunotherapy; CAR-T; NK cell

(This special issue belongs to the Section Cancer Therapy)

Enhancing Precision in Cancer Treatment: AI-Driven Innovations in Imaging

edited by Andra Valentina Krauze

submission deadline 30 Nov 2025 | 4 articles | Viewed by 8061 | Submission Open

Keywords: precision medicine; artificial intelligence; medical imaging; cancer treatment; AI-driven innovations

(This special issue belongs to the Section Methods and Technologies Development)

Evolution of B-Cell Malignancy Therapy and Treatment Resistance: Where Are We Headed? (2nd Edition)

edited by Jianguo Tao, Jeffrey W. Craig and Michael E. Williams

submission deadline 30 Nov 2025 | 3 articles | Viewed by 7771 | Submission Open

Keywords: B-cell malignancy; drug resistance; novel therapy; TME; chemoimmunotherapy; targeted agents; immunotherapeutic approaches

(This special issue belongs to the Section Cancer Therapy)

Targeting Tumor Microenvironment in Cancer: An Impact on Therapeutic Efficacy

edited by

Inamul Haque

submission deadline 30 Nov 2025 | 2 articles | Viewed by 7327 | Submission Open

Keywords: VEGF/VEGFR-targeted therapy; immune checkpoint blockade; recent advances and challenges in tumor microenvironment targeting; targeting cancer stem cells; tumor microenvironment and its therapeutic implications; microbiome

(This special issue belongs to the Section Cancer Therapy)

Surgical Treatment of Abdominal Tumors

edited by

Konstantinos Perivoliotis

and Ioannis Baloyiannis

submission deadline 30 Nov 2025 | 3 articles | Viewed by 5285 | Submission Open

Keywords: abdominal; abdominal wall; tumors; surgery; cancer; malignancy; oncology; intraperitoneal; extraperitoneal

(This special issue belongs to the Section Clinical Research of Cancer)

Growth Factors and Receptor Tyrosine Kinases in Development, Regeneration, and Tumorigenesis (2nd Edition)

edited by

Carl-Henrik Heldin

submission deadline 30 Nov 2025 | 1 articles | Viewed by 4735 | Submission Open

Keywords: receptor; tyrosine kinase; growth factor; signal transduction; development regeneration tumorigenesis

(This special issue belongs to the Section Molecular Cancer Biology)

Novel Computational Approaches for Molecular Target Discovery in Colorectal Cancer

edited by

Giovanni Crisafulli

submission deadline 30 Nov 2025 | 1 articles | Viewed by 4459 | Submission Open

Keywords: colorectal cancer; genetics; bioinformatics; therapeutic targets; cancer evolution; personalized medicine; patient stratification; technological advancements; precision oncology; big data; computational approach

(This special issue belongs to the Section Methods and Technologies Development)

Tissue-Agnostic Drug Development in Cancer (2nd Edition)

edited by Shivaani Kummar and

Kyaw Thein

submission deadline 30 Nov 2025 | 1 articles | Viewed by 3886 | Submission Open

Keywords: tissue-agnostic drug development; pembrolizumab; microsatellite instability-high (MSI-H); tumor mutational burden-high (TMB-H); dostarlimab-gxly; larotrectinib; entrectinib; neurotrophic tyrosine kinase (NTRK)-fusion-positive solid tumors; dabrafenib and trametinib; selpercatinib; rearranged during transfection (RET) gene fusion; precision medicine

(This special issue belongs to the Section Cancer Drug Development)

Molecular Pathways in Cancers (2nd Edition)

edited by

Ion Cristóbal

and

Marta Rodríguez Moreno

submission deadline 30 Nov 2025 | 2 articles | Viewed by 3607 | Submission Open

Keywords: highly prevalent cancers; tumor microenvironment; oncogenesis; progression; novel targeted therapy; prognosis

(This special issue belongs to the Section Molecular Cancer Biology)

Image Analysis and Machine Learning in Cancers: 2nd Edition

edited by

Helder C. R. De Oliveira

and

Arianna Mencattini

submission deadline 30 Nov 2025 | 2 articles | Viewed by 3247 | Submission Open

Keywords: cancer detection and diagnosis system; machine learning; deep learning; medical imaging analysis; few-shot deep learning; attention segmentation; feature extraction; probabilistic models; explainability; image fusion; generative adversarial network

(This special issue belongs to the Section Methods and Technologies Development)

Calcium Signaling in Cancer Cell Progression

edited by

Amantini Consuelo

submission deadline 30 Nov 2025 | 1 articles | Viewed by 2856 | Submission Open

Keywords: interorganellar Ca2+ communication; membrane contact sites; tumor progression; intracellular Ca2+ flux; cation channels; calcium dysregulation; cell fate; targeted therapy

(This special issue belongs to the Section Cancer Pathophysiology)

Tumor Microenvironment in Primary Liver Cancer 2nd edition

edited by

Stefania Mantovani

and

Barbara Oliviero

submission deadline 30 Nov 2025 | 1 articles | Viewed by 2738 | Submission Open

Keywords: liver cancer; hepatocellular carcinoma; cholangiocarcinoma; tumor immunology; immune system; tumor microenvironment; NK cells; cancer-associated fibroblast; extracellular vesicles; secretome

(This special issue belongs to the Section Tumor Microenvironment)

Epigenetics in Cancer and Drug Therapeutics

edited by Bethsebie Sailo and Anup R. Sharma

submission deadline 30 Nov 2025 | 1 articles | Viewed by 2059 | Submission Open

Keywords: cancer epigenetics; chromatin remodeling complexes; histone modifiers; DNA methylation; molecular target; cancer therapy

(This special issue belongs to the Section Molecular Cancer Biology)

The Advance of Clinical Therapy and Prognosis in Gastrointestinal Cancer

edited by Liliana Streba and Michael Schenker

submission deadline 30 Nov 2025 | 1 articles | Viewed by 2044 | Submission Open

Keywords: gastrointestinal cancer; tumorigenesis; microbiome; early detection; molecular mechanisms; personalized medicine; novel therapeutics; translational research; clinical application; diagnostic innovations

(This special issue belongs to the Section Clinical Research of Cancer)

Clinical Efficacy of Drug Therapy in Gastrointestinal Cancers

edited by

Francesco Tonelli

and

Enrico Mini

submission deadline 30 Nov 2025 | 2 articles | Viewed by 2028 | Submission Open

Keywords: classical chemotherapy; targeted therapeutics; immunotherapy; adjuvant therapy; neoadjuvant therapy; induction therapy; multidisciplinary treatments; gastric cancer; colorectal cancer

(This special issue belongs to the Section Clinical Research of Cancer)

New and Future Focused Therapies for Thyroid Cancer

edited by

Alessandro Antonelli

, Poupak Fallahi, Silvia Martina Ferrari and Giusy Elia

submission deadline 30 Nov 2025 | 1 articles | Viewed by 1935 | Submission Open

Keywords: aggressive differentiated thyroid carcinoma; anaplastic thyroid cancer; tyrosine kinase inhibitors; immunotherapy; personalized medicine

(This special issue belongs to the Section Cancer Therapy)

Advances in Castration-Resistant Prostate Cancer Treatment

edited by

Eswar Shankar

and

Balaji Chandrasekaran

submission deadline 30 Nov 2025 | 1 articles | Viewed by 1826 | Submission Open

Keywords: androgen receptor; CRPC; chemoresistance; combination therapy; small molecules; chemoprevention; ubiquitination

(This special issue belongs to the Section Cancer Therapy)

Surgery in Metastatic Cancer (2nd Edition)

edited by

Ulrich Ronellenfitsch

submission deadline 30 Nov 2025 | 1 articles | Viewed by 1333 | Submission Open

Keywords: metastatic cancer; surgery; metastasectomy; indication; timing

(This special issue belongs to the Section Cancer Therapy)

Epstein-Barr Virus-Associated Cancers: From Pathogenesis to Treatment (2nd Edition)

edited by

Kwok-Wai Lo

submission deadline 30 Nov 2025 | 1 articles | Viewed by 1033 | Submission Open

Keywords: EBV; lymphomas; Burkitt lymphoma; Hodgkin lymphoma; NK/T cell lymphoma; nasopharyngeal carcinoma; gastric cancer; biomarkers; immunotherapy; targeted therapy

(This special issue belongs to the Section Infectious Agents and Cancer)

Radiotherapy for Head and Neck Squamous Cell Carcinoma (2nd Edition)

edited by Cesare Guida and Ida D'Onofrio

submission deadline 30 Nov 2025 | 1 articles | Viewed by 1021 | Submission Open

Keywords: head and neck squamous cell carcinoma; radiotherapy; biomarker; chemoradiotherapy; head and neck cancers

(This special issue belongs to the Section Cancer Therapy)

Clinical and Surgical Therapy for Colorectal Cancer

edited by Laura Koskenvuo

submission deadline 30 Nov 2025 | 1 articles | Viewed by 894 | Submission Open

Keywords: colorectal cancer; rectal cancer; anterior resection; minimally invasive surgery; robotic surgery; surgical oncology; neoadjuvant therapy; adjuvant therapy; quality of life; gut microbiome

(This special issue belongs to the Section Cancer Therapy)

Recent Advances in the Molecular Genetics of Sarcomas

edited by Wei Jiang

submission deadline 30 Nov 2025 | Viewed by 501 | Submission Open

Keywords: sarcoma; bone and soft tissue; molecular genetics; molecular pathology; classification

(This special issue belongs to the Section Molecular Cancer Biology)

Mesothelioma: Diagnosis and Therapy

edited by Avinash Aujayeb

submission deadline 30 Nov 2025 | Viewed by 389 | Submission Open

Keywords: malignant pleural mesothelioma; diagnostics; immunotherapy treatment; surgical treatments; intrapleural therapy

(This special issue belongs to the Section Cancer Therapy)

Disparities in Thoracic Oncology Patients

edited by Jeffrey B. Velotta and

Nestor Villamizar

submission deadline 30 Nov 2025 | Viewed by 329 | Submission Open

Keywords: lung cancer; disparities; thoracic oncology

(This special issue belongs to the Section Cancer Epidemiology and Prevention)

Non-Coding RNAs and Extracellular Vesicles in Cancer Crosstalk: Diagnostic and Therapeutic Implications 2nd Edition

edited by

Simona Taverna

and

Giuseppe Cammarata

submission deadline 30 Nov 2025 | Viewed by 307 | Submission Open

Keywords: extracellular vesicles; exosomes; cancer; inflammation; non-coding RNA; microRNAs; circular-RNAs; PIWI-RNAs; lnc-RNAs

(This special issue belongs to the Section Cancer Therapy)

Gastric Cancers: Molecular Mechanisms, Novel Targets and Immunotherapies: From Bench to Clinical Therapeutics (2nd Edition)

edited by

Shumei Song

and

Jaffer A. Ajani

submission deadline 30 Nov 2025 | Viewed by 259 | Submission Open

Keywords: novel oncogene targets; interplay among cancer; stroma; and immune cells; tumor microenvironment (TME); immune biomarker; immunotherapy; new therapeutic modality; translational research; clinical trials

(This special issue belongs to the Section Molecular Cancer Biology)

New Approaches in Modulating Transcription Factors for Cancer Therapy: 2nd Edition

edited by

Sarah Walker

submission deadline 30 Nov 2025 | Viewed by 254 | Submission Open

Keywords: transcription factors; cancer treatment; degraders; inhibitors

(This special issue belongs to the Section Cancer Therapy)

Integrin Beta-1 Signaling in Cancers

edited by Adama Sidibé and Bernhard Wehrle-Haller

submission deadline 30 Nov 2025 | Viewed by 167 | Submission Open

Keywords: integrin beta-1; cancer cell; tissue stroma; fibrosis; talin-1; paxillin; kinases; acetyltransferases; FAK; SRC kinase; SFK; cell proliferation; adhesion; migration; drug resistance

(This special issue belongs to the Section Molecular Cancer Biology)

Gastrointestinal and Its Associated Malignancies: Diagnosis, Targets and Therapies

edited by Ganji P. Nagaraju and

Seema Kumari

submission deadline 1 Dec 2025 | 3 articles | Viewed by 9630 | Submission Open

Keywords: GI cancers; oncogenesis; diagnosis; target identification; biomarkers; therapy

(This special issue belongs to the Section Cancer Therapy)

Clinical Studies in Gastrointestinal Malignancies

edited by

Ulrich Ronellenfitsch

submission deadline 1 Dec 2025 | 4 articles | Viewed by 7607 | Submission Open

Keywords: gastrointestinal cancers; clinical studies; multimodal treatment; study design; outcomes

(This special issue belongs to the Section Clinical Research of Cancer)

Post-transcriptional Regulation of Cancer-Related Processes

edited by

Cyril Sobolewski

submission deadline 1 Dec 2025 | 1 articles | Viewed by 3544 | Submission Open

Keywords: microRNAs; long-non-coding RNA; RNA-binding proteins; stress granules; P-bodies

(This special issue belongs to the Section Tumor Microenvironment)

Latest Breakthroughs in Tumor Immune Microenvironment: From Cellular Discovery to Cutting-Edge Technology

edited by

Ira-Ida Skvortsova

Johjong Huang

and

Hsin-Hua Lee

submission deadline 5 Dec 2025 | 5 articles | Viewed by 12981 | Submission Open

Keywords: tumor microenvironment; natural food extracts; molecular markers; abscopal effect; RT technology; prognosis; side effects and abscopal effects

(This special issue belongs to the Section Tumor Microenvironment)

Mesothelioma—from Diagnosis to Treatment

edited by

Nobukazu Fujimoto

submission deadline 5 Dec 2025 | 4 articles | Viewed by 11235 | Submission Open

Keywords: asbestos; BAP-1; CAR-T; CTLA-4; immunotherapy; mesothelioma; PD-1; PD-L1

(This special issue belongs to the Section Cancer Therapy)

Paradigm Shifts in Gynaecological Oncology Surgery

edited by

Faiza Gaba

submission deadline 5 Dec 2025 | 3 articles | Viewed by 6219 | Submission Open

Keywords: gynecological surgery; genomics risk management; survivorship health economics

(This special issue belongs to the Section Cancer Epidemiology and Prevention)

NK Cells in the Tumor Microenvironment: Immunosuppressive Mechanisms and Therapy

edited by

Alexander Barrow

and Julian Vivian

submission deadline 5 Dec 2025 | 2 articles | Viewed by 3965 | Submission Open

Keywords: immunosuppression; activation; inhibition; receptor; NK-CAR; checkpoint; adoptive cell therapy; immunotherapy; tumor microenvironment; nanoparticles

(This special issue belongs to the Section Cancer Immunology and Immunotherapy)

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