Prostate Cancer Progression

Dear Colleagues, 

Prostate cancer (PC) is one of the most prevalent malignancies of the present day. While most cases are diagnosed at a localized stage, a considerable number of patients with intermediate or high-risk localized, locally advanced or metastatic cancer die from the disease itself each year. Although therapeutic advances have been introduced in the field of metastatic PC in recent years, androgen deprivation therapy (ADT) remains the leading therapeutic backbone for metastatic PC. However, most patients develop castration resistance. The exact mechanisms driving the progression from androgen-dependent PC to castration-resistant prostate cancer (CRPC) are not completely understood.In recent years, the treatment landscape of metastatic CRPC (mCRPC) has substantially improved due to the availability of different agents. However, fast tumor progression, cross-resistance, the use of these substances in earlier (hormone-sensitive) stages of the disease, and patient-related factors should be taken into account when assessing which is the optimal treatment sequencing in the setting of mCRPC. This Special Issue aims, on one hand, to better understand the biological mechanisms of tumor progression and, on the other hand, to elucidate recent clinical developments in the treatment of both localized and metastatic disease.

Dr. Isabel Heidegger-Pircher
Guest Editor

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