CRISPR/Cas System-Based Biosensors

Dear Colleagues,

In recent years, the CRISPR/Cas system-based biosensors have attracted much attention in medical diagnoses, food safety, agricultural progress, and environmental monitoring. Furthermore, the CRISPR/Cas based analytic methods have evolved into versatile analytical platforms owing to their good sensitivity, high selectivity, and fast detection efficiency. A series of nucleic acid and non-nucleic acid detection biosensors based on the CRISPR platform have been developed. The high-performance CRISPR biosensors in combination with fluorescence, colorimetry, potentiometry, lateral flow assay have become the mainstream research trend. Newly discovered CRISPR/Cas systems and the engineering of the existing CRISPR/Cas systems would aid to increase the specificity, sensitivity, or stability of the diagnostic tools. To finish the clinical transition of diagnostics from their research use has also been the hot topic in recent years, and the CRISPR/Cas approaches will emerge as more promising and robust tools for various disease diagnoses and point-of-care tests in the future.

For this Special Issue, we welcome original research papers as well as reviews on the current developments in the design of high-sensitivity and reproducible systems with CRISPR/Cas-based biosensing technologies in the application of cancer and infectious diseases diagnoses. This includes the design of state-of-the-art CRISPR/Cas-based biosensing strategies. Theoretical research on the CRISPR/Cas-based biosensing mechanism is also encouraged. The design and development of lab-on-a-chip devices, wearable and plug-and-play biosensors, and portable/handheld CRISPR/Cas-based platforms for point-of-care applications are of special interest. Reviews should provide an in-depth examination of the most recent research in a specific context or discuss the existing and future obstacles for the commercial application of CRISPR detection technology and explore development opportunities and directions.

Prof. Dr. Shiping Song
Dr. Jing Su
Guest Editors

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• CRISPR/Cas system
• biosensor
• biochip
• lab on a chip
• portable biosensing device
• wearable biosensing device
• POCT
• disease diagnosis