Molecular Targets in Campylobacter Infections

Dear Colleagues,

Zoonotic Campylobacter jejuni is a major cause of foodborne bacterial infections worldwide. The bacterium triggers campylobacteriosis in the human gut, which can progress to serious secondary disorders after infection, including reactive arthritis and Guillain-Barré syndrome. In this scenario, the pathogen targets various host cell factors, including certain cell surface receptors, endocytic machinery, cytoskeleton and inflammasome formation by virulence-associated bacterial determinants such as the flagellum, protein adhesins, cytolethal distending toxin, lipooligosaccharide, serine protease HtrA, M24, etc. These factors are involved in several pathogenicity-linked properties that can be divided into bacterial motility, chemotaxis, attachment, invasion, intracellular survival, cellular transmigration and can spread into deeper tissues. In the current Special Issue of Biomolecules, we invite research papers and review articles concerning all kinds of interactions between these bacteria and host cells.

Prof. Dr. Steffen Backert
Guest Editor

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