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Biomedicines
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Recent Advances in Tumor Cell Migration
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Recent Advances in Tumor Cell Migration

A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Cell Biology and Pathology".

Deadline for manuscript submissions: closed (15 March 2024) | Viewed by 3014

Special Issue Editor

Dr. Patrizia Mancini

E-Mail Website
Guest Editor
Dipartimento di Medicina Sperimentale, Sapienza Università di Roma, Viale Regina Elena 324, 00161 Rome, Italy
Interests: cell migration; actin cytoskeleton organization; immunofluorescence microscopy analysis; growth factors; receptor tyrosine kinases; Src protein

Special Issue Information

Dear Colleagues,

Cell migration is a crucial step in many physiological events, as well as in the physiopathology of many diseases, such as cancer. Invasion and metastasis dissemination are dynamic processes regulated by cell–cell and cell–matrix adhesion changes, migration, cytoskeleton dynamics, invasion of surrounding tissues, and extracellular remodeling. Growth factors and cytokines produced in the tumor microenvironment regulate the migration of cancer cells by activating different signaling pathways that control the movement of cancer cells, including collective and single-cell migration, and their ability to modulate themselves according to their needs.

This Special Issue focuses on recent advances in the migratory behavior of cancer cells after stimulation with growth factors and/or cytokines. In particular, reports with morphological evaluation carried out with image analysis and relative quantization of cell migration in various biological models, combined with the molecular study which allows efficiently analyzing tumor cell migration, by taking into account their ability to mimic the in vivo reality, are welcome. Of importance are also the molecules involved in signal transduction that regulate tumor invasion and metastasis dissemination, to evaluate the possibility of using these substrates as new therapeutic targets.

Dr. Patrizia Mancini
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomedicines is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • tumor cell migration
  • actin cytoskeleton organization
  • growth factors
  • cytokines
  • cell-adhesion molecules
  • receptor tyrosine kinases

Published Papers (2 papers)

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Research

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23 pages, 17784 KiB  
Article
Interaction of Drug-Sensitive and -Resistant Human Melanoma Cells with HUVEC Cells: A Label-Free Cell-Based Impedance Study
by Giuseppina Bozzuto, Marisa Colone, Laura Toccacieli, Agnese Molinari, Annarica Calcabrini and Annarita Stringaro
Biomedicines 2023, 11(6), 1544; https://doi.org/10.3390/biomedicines11061544 - 26 May 2023
Cited by 2 | Viewed by 1293
Abstract
Cancer cell extravasation is a crucial step in cancer metastasis. However, many of the mechanisms involved in this process are only now being elucidated. Thus, in the present study we analysed the trans-endothelial invasion of melanoma cells by a high throughput label-free cell [...] Read more.
Cancer cell extravasation is a crucial step in cancer metastasis. However, many of the mechanisms involved in this process are only now being elucidated. Thus, in the present study we analysed the trans-endothelial invasion of melanoma cells by a high throughput label-free cell impedance assay applied to transwell chamber invasion assay. This technique monitors and quantifies in real-time the invasion of endothelial cells by malignant tumour cells, for a long time, avoiding artefacts due to preparation of the end point measurements. Results obtained by impedance analysis were compared with endpoint measurements. In this study, we used human melanoma M14 wild type (WT) cells and their drug resistant counterparts, M14 multidrug resistant (ADR) melanoma cells, selected by prolonged exposure to doxorubicin (DOX). Tumour cells were co-cultured with monolayers of human umbilical vein endothelial cells (HUVEC). Results herein reported demonstrated that: (i) the trans-endothelial migration of resistant melanoma cells was faster than sensitive ones; (ii) the endothelial cells appeared to be strongly affected by the transmigration of melanoma cells which showed the ability to degrade their cytoplasm; (iii) resistant cells preferentially adopted the transcellular invasion vs. the paracellular one; (iv) the endothelial damage mediated by tumour metalloproteinases seemed to be reversible. Full article
(This article belongs to the Special Issue Recent Advances in Tumor Cell Migration)
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Review

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34 pages, 786 KiB  
Review
Tumor Microenvironment Remodeling in Gastrointestinal Cancer: Role of miRNAs as Biomarkers of Tumor Invasion
by Valeria Lucarini, Daniela Nardozi, Valentina Angiolini, Monica Benvenuto, Chiara Focaccetti, Raffaele Carrano, Zein Mersini Besharat, Roberto Bei and Laura Masuelli
Biomedicines 2023, 11(6), 1761; https://doi.org/10.3390/biomedicines11061761 - 19 Jun 2023
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Abstract
Gastrointestinal (GI) cancers are the most frequent neoplasm, responsible for half of all cancer-related deaths. Metastasis is the leading cause of death from GI cancer; thus, studying the processes that regulate cancer cell migration is of paramount importance for the development of new [...] Read more.
Gastrointestinal (GI) cancers are the most frequent neoplasm, responsible for half of all cancer-related deaths. Metastasis is the leading cause of death from GI cancer; thus, studying the processes that regulate cancer cell migration is of paramount importance for the development of new therapeutic strategies. In this review, we summarize the mechanisms adopted by cancer cells to promote cell migration and the subsequent metastasis formation by highlighting the key role that tumor microenvironment components play in deregulating cellular pathways involved in these processes. We, therefore, provide an overview of the role of different microRNAs in promoting tumor metastasis and their role as potential biomarkers for the prognosis, monitoring, and diagnosis of GI cancer patients. Finally, we relate the possible use of nutraceuticals as a new strategy for targeting numerous microRNAs and different pathways involved in GI tumor invasiveness. Full article
(This article belongs to the Special Issue Recent Advances in Tumor Cell Migration)
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