Abstract: Congenital heart disease (CHD) affects the intricate structure and function of the heart and is one of the leading causes of death in newborns. The genetic basis of CHD is beginning to emerge. Our laboratory has been engaged in identifying mutations in genes linked to CHD both in families and in sporadic cases. Over the last two decades, we have employed linkage analysis, targeted gene sequencing and genome wide association studies to identify genes involved in CHDs. Cardiac specific genes that encode transcription factors and sarcomeric proteins have been identified and linked to CHD. Functional analysis of the relevant mutant proteins has established the molecular mechanisms of CHDs in our studies.
This is an open access article distributed under the
Creative Commons Attribution License which permits unrestricted use, distribution,
and reproduction in any medium, provided the original work is properly cited.
Export to BibTeX
MDPI and ACS Style
Ghosh, T.K.; Granados-Riveron, J.T.; Buxton, S.; Setchfield, K.; Loughna, S.; Brook, J.D. Studies of Genes Involved in Congenital Heart Disease. J. Cardiovasc. Dev. Dis. 2014, 1, 134-145.
Ghosh TK, Granados-Riveron JT, Buxton S, Setchfield K, Loughna S, Brook JD. Studies of Genes Involved in Congenital Heart Disease. Journal of Cardiovascular Development and Disease. 2014; 1(1):134-145.
Ghosh, Tushar K.; Granados-Riveron, Javier T.; Buxton, Sarah; Setchfield, Kerry; Loughna, Siobhan; Brook, J. D. 2014. "Studies of Genes Involved in Congenital Heart Disease." J. Cardiovasc. Dev. Dis. 1, no. 1: 134-145.