Next Article in Journal
Evidence of Aortopathy in Mice with Haploinsufficiency of Notch1 in Nos3-Null Background
Previous Article in Journal
Acknowledgement to Reviewers of the Journal of Cardiovascular Development and Disease in 2014
Previous Article in Special Issue
Studies of Genes Involved in Congenital Heart Disease
Article Menu

Export Article

Open AccessReview
J. Cardiovasc. Dev. Dis. 2015, 2(1), 2-16; doi:10.3390/jcdd2010002

Cellular Mechanisms of Drosophila Heart Morphogenesis

Development, Aging and Regeneration Program, Sanford-Burnham Medical Research Institute, 10901 N. Torrey Pines Road, La Jolla, CA 92037, USA
*
Author to whom correspondence should be addressed.
Academic Editor: Silke R. Sperling
Received: 6 December 2014 / Revised: 7 February 2015 / Accepted: 11 February 2015 / Published: 16 February 2015
View Full-Text   |   Download PDF [780 KB, uploaded 17 February 2015]   |  

Abstract

Many of the major discoveries in the fields of genetics and developmental biology have been made using the fruit fly, Drosophila melanogaster. With regard to heart development, the conserved network of core cardiac transcription factors that underlies cardiogenesis has been studied in great detail in the fly, and the importance of several signaling pathways that regulate heart morphogenesis, such as Slit/Robo, was first shown in the fly model. Recent technological advances have led to a large increase in the genomic data available from patients with congenital heart disease (CHD). This has highlighted a number of candidate genes and gene networks that are potentially involved in CHD. To validate genes and genetic interactions among candidate CHD-causing alleles and to better understand heart formation in general are major tasks. The specific limitations of the various cardiac model systems currently employed (mammalian and fish models) provide a niche for the fly model, despite its evolutionary distance to vertebrates and humans. Here, we review recent advances made using the Drosophila embryo that identify factors relevant for heart formation. These underline how this model organism still is invaluable for a better understanding of CHD. View Full-Text
Keywords: Drosophila; cardiogenesis; morphogenesis; tinman; Cdc42; congenital heart disease; non-muscle myosin; zipper Drosophila; cardiogenesis; morphogenesis; tinman; Cdc42; congenital heart disease; non-muscle myosin; zipper
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Vogler, G.; Bodmer, R. Cellular Mechanisms of Drosophila Heart Morphogenesis. J. Cardiovasc. Dev. Dis. 2015, 2, 2-16.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
J. Cardiovasc. Dev. Dis. EISSN 2308-3425 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top