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Vet. Sci. 2014, 1(1), 63-76; doi:10.3390/vetsci1010063
Review

Respiratory Animal Models in the Common Marmoset (Callithrix jacchus)

1,2
, 1,2
 and 1,*
Received: 23 April 2014; in revised form: 6 June 2014 / Accepted: 10 June 2014 / Published: 20 June 2014
(This article belongs to the Special Issue Animal Models of Disease)
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Abstract: Common marmosets (Callithrix jacchus) are small non-human primates (NHPs) that are often used for respiratory research. Translational animal models of various pulmonary diseases in marmosets have been developed in favor of models in old world monkeys (OWM, e.g., rhesus or cynomolgus monkeys). The marmoset has the size of a rat (350–450 g), is easier to handle, and the husbandry, care, and management of colonies is much easier compared to OWMs. In contrast to rodents, marmosets provide a high homology to humans, which become especially visible in lung architecture and branching pattern. Features of inflammatory (e.g., COPD) pulmonary diseases can be modeled in marmosets as well the species is used to study bacterial and viral infection. Models for human melioidosis, tuberculosis, anthrax, as well as infections with SARS-associated coronavirus (SARS-CoV), influenza A virus and adenovirus are already established. Toxicological studies often use marmoset monkeys for the advantage of immunological identical twins that are produced by a Callitrichinae-specific placentation type, which ultimately causes blood chimerism. Relatively new approaches in gene therapy use marmosets for respiratory disease research. In this review we will give an overview of existing respiratory marmoset models and their impact on biomedical research.
Keywords: marmoset; non-human primate; animal models; respiratory diseases marmoset; non-human primate; animal models; respiratory diseases
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Curths, C.; Knauf, S.; Kaup, F.-J. Respiratory Animal Models in the Common Marmoset (Callithrix jacchus). Vet. Sci. 2014, 1, 63-76.

AMA Style

Curths C, Knauf S, Kaup F-J. Respiratory Animal Models in the Common Marmoset (Callithrix jacchus). Veterinary Sciences. 2014; 1(1):63-76.

Chicago/Turabian Style

Curths, Christoph; Knauf, Sascha; Kaup, Franz-Josef. 2014. "Respiratory Animal Models in the Common Marmoset (Callithrix jacchus)." Vet. Sci. 1, no. 1: 63-76.

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