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Chromatography 2014, 1(3), 108-119; doi:10.3390/chromatography1030108

Exhaled Breath Condensate for Proteomic Biomarker Discovery

1,* , 2
Received: 8 May 2014 / Revised: 20 June 2014 / Accepted: 24 June 2014 / Published: 2 July 2014
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Exhaled breath condensate (EBC) has been established as a potential source of respiratory biomarkers. Compared to the numerous small molecules identified, the protein content of EBC has remained relatively unstudied due to the methodological and technical difficulties surrounding EBC analysis. In this review, we discuss the proteins identified in EBC, by mass spectrometry, focusing on the significance of those proteins identified. We will also review the limitations surrounding mass spectral EBC protein analysis emphasizing recommendations to enhance EBC protein identifications by mass spectrometry. Finally, we will provide insight into the future directions of the EBC proteomics field.
Keywords: exhaled breath condensate; proteomics; mass spectrometry exhaled breath condensate; proteomics; mass spectrometry
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Harshman, S.W.; Grigsby, C.C.; Ott, D.K. Exhaled Breath Condensate for Proteomic Biomarker Discovery. Chromatography 2014, 1, 108-119.

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