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Chromatography 2014, 1(3), 108-119; doi:10.3390/chromatography1030108
Review

Exhaled Breath Condensate for Proteomic Biomarker Discovery

1,* , 2
 and 3
Received: 8 May 2014; in revised form: 20 June 2014 / Accepted: 24 June 2014 / Published: 2 July 2014
View Full-Text   |   Download PDF [192 KB, uploaded 2 July 2014]
Abstract: Exhaled breath condensate (EBC) has been established as a potential source of respiratory biomarkers. Compared to the numerous small molecules identified, the protein content of EBC has remained relatively unstudied due to the methodological and technical difficulties surrounding EBC analysis. In this review, we discuss the proteins identified in EBC, by mass spectrometry, focusing on the significance of those proteins identified. We will also review the limitations surrounding mass spectral EBC protein analysis emphasizing recommendations to enhance EBC protein identifications by mass spectrometry. Finally, we will provide insight into the future directions of the EBC proteomics field.
Keywords: exhaled breath condensate; proteomics; mass spectrometry exhaled breath condensate; proteomics; mass spectrometry
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Harshman, S.W.; Grigsby, C.C.; Ott, D.K. Exhaled Breath Condensate for Proteomic Biomarker Discovery. Chromatography 2014, 1, 108-119.

AMA Style

Harshman SW, Grigsby CC, Ott DK. Exhaled Breath Condensate for Proteomic Biomarker Discovery. Chromatography. 2014; 1(3):108-119.

Chicago/Turabian Style

Harshman, Sean W.; Grigsby, Claude C.; Ott, Darrin K. 2014. "Exhaled Breath Condensate for Proteomic Biomarker Discovery." Chromatography 1, no. 3: 108-119.

Chromatography EISSN 2227-9075 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert