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Biomedicines 2017, 5(3), 40; doi:10.3390/biomedicines5030040

In Vitro Testing of Crude Natural Plant Extracts from Costa Rica for Their Ability to Boost Innate Immune Cells against Staphylococcus aureus

1
Department of Physiological Chemistry, University of Veterinary Medicine Hannover, Bünteweg 17, 30559 Hannover, Germany
2
Botany & Microbiology Department, Cairo University, Giza 12613, Egypt
3
Department of Chemistry, University of Alabama in Huntsville, Huntsville, AL 35899, USA
4
Research Center for Emerging Infections and Zoonoses (RIZ), University of Veterinary Medicine Hannover, Bünteweg 17, 30559 Hannover, Germany
*
Author to whom correspondence should be addressed.
Received: 4 June 2017 / Revised: 24 June 2017 / Accepted: 28 June 2017 / Published: 5 July 2017
(This article belongs to the Special Issue Plant Derived Biomedicines)
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Abstract

The increasing occurrence of antibiotic-resistant Staphylococcus (S.) aureus tremendously limits the antibiotic-based treatment options; therefore, an open discussion of alternative treatment strategies is urgently needed. The use of naturally derived materials might become a more promising concept, not only as directly acting antimicrobials, but also for stimulation of the immune system. Costa Rican plant extracts were screened for their ability to enhance the antimicrobial activity of human blood-derived cells against S. aureus infections. We identified three plant extracts which significantly reduced the growth of S. aureus in the presence of human blood without directly acting as antibacterials: Byrsonima crassifolia acetone bark extract, Mandevilla veraguasensis acetone vine extract and Verbesina oerstediana acetone bark extract (VEOEBA). The effect of VEOEBA was studied in more detail, and revealed that VEOEBA increases the antimicrobial activity of neutrophils by enhancing the formation of neutrophil extracellular traps. View Full-Text
Keywords: monocytes; neutrophil; neutrophil extracellular trap; Byrsonima crassifolia; Mandevilla veraguasensis; Verbesina oerstediana monocytes; neutrophil; neutrophil extracellular trap; Byrsonima crassifolia; Mandevilla veraguasensis; Verbesina oerstediana
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Yaseen, R.; Branitzki-Heinemann, K.; Moubasher, H.; Setzer, W.N.; Naim, H.Y.; von Köckritz-Blickwede, M. In Vitro Testing of Crude Natural Plant Extracts from Costa Rica for Their Ability to Boost Innate Immune Cells against Staphylococcus aureus. Biomedicines 2017, 5, 40.

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