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Biomedicines 2017, 5(3), 38; doi:10.3390/biomedicines5030038

New Paradigm for a Targeted Cancer Therapeutic Approach: A Short Review on Potential Synergy of Gold Nanoparticles and Cold Atmospheric Plasma

1
Department of Biotechnology, School of Science, Kathmandu University, Dhulikhel 45200, Nepal
2
Department of Chemical Science and Engineering, Kathmandu University, Dhulikhel 45200, Nepal
*
Author to whom correspondence should be addressed.
Received: 30 April 2017 / Revised: 16 June 2017 / Accepted: 27 June 2017 / Published: 1 July 2017
(This article belongs to the Special Issue Photodynamic Therapy in Cancer)
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Abstract

Application of Gold nanoparticles and Cold Atmospheric plasma as a targeted therapeutic adjunct has been widely investigated separately in cancer therapy. Gold nanoparticles, with their biocompatibility, lower cytotoxicity and superior efficacy, are becoming substantially more significant in modern cancer therapy. Likewise, cold atmospheric plasma, with rich reactive species including reactive oxygen species (ROS) and reactive nitrogen species (RNS), is being explored to selectively target and kill cancer cells, making them a promising anticancer agent. Recent scientific studies have shown that there is a potential synergy between these two aspects. Induction of apoptosis/necrosis due to oxidative stress may be a probable mechanism of their cytotoxic effect. The synergetic effect of the two therapeutic approaches could be tantamount to maximized targeted efficacy on the treatment of diseases like cancer. View Full-Text
Keywords: gold nanoparticles; atmospheric cold plasma; tumor-specific targeted therapy gold nanoparticles; atmospheric cold plasma; tumor-specific targeted therapy
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Aryal, S.; Bisht, G. New Paradigm for a Targeted Cancer Therapeutic Approach: A Short Review on Potential Synergy of Gold Nanoparticles and Cold Atmospheric Plasma. Biomedicines 2017, 5, 38.

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