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Biomedicines 2017, 5(2), 18; doi:10.3390/biomedicines5020018

The Protective Effects of p-Coumaric Acid on Acute Liver and Kidney Damages Induced by Cisplatin

1
Department of Nutrition and Dietetics, High School of Health, Agri İbrahim Cecen University, Agri 04100, Turkey
2
Department of Medical Laboratory, Health Services Vocational Training School, Atatürk University, Erzurum 25240, Turkey
3
Department of Pathology, Faculty of Medicine, Atatürk University, Erzurum 25240, Turkey
4
Department of Biochemistry, Faculty of Pharmacy, Atatürk University, Erzurum 25240, Turkey
5
Department of Chemistry, Faculty of Science, Atatürk University, Erzurum 25240, Turkey
*
Authors to whom correspondence should be addressed.
Academic Editors: Solomon Habtemariam and Giovanni Lentini
Received: 19 February 2017 / Revised: 24 April 2017 / Accepted: 25 April 2017 / Published: 28 April 2017
(This article belongs to the Special Issue Plant Derived Biomedicines)
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Abstract

In this study, we aimed to investigate the effects of p-Coumaric acid (PCA) on cisplatin (CIS)-induced hepatotoxicity and nephrotoxicity in Wistar adult rats for 24 h compared to untreated control groups. In this experiment, 40 Wistar adult rats were utilized and divided randomly into five groups. After 24 h of CIS administration, liver and kidneys were harvested and assessed by H&E staining. Also, markers for oxidative stress and antioxidants were analyzed in theses tissues. Compared to the control group, accumulation of malondialdehyde was increased in groups treated CIS, whereas superoxide dismutase activities and glutathione levels were distinctly diminished in this group. The study’s histopathological findings such as hydropic degeneration, vascular congestion, sinusoidal dilatation in hepatocytes and tubular necrosis in kidneys were in accordance with the results of markers for oxidative stress. PCA may prevent hepatotoxicity and nephrotoxicity by increased antioxidant enzymes and reduced oxidant parameters. View Full-Text
Keywords: hepatotoxicity; nephrotoxicity; p-Coumaric acid; antioxidant activity; oxidative stress hepatotoxicity; nephrotoxicity; p-Coumaric acid; antioxidant activity; oxidative stress
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Ekinci Akdemir, F.N.; Albayrak, M.; Çalik, M.; Bayir, Y.; Gülçin, İ. The Protective Effects of p-Coumaric Acid on Acute Liver and Kidney Damages Induced by Cisplatin. Biomedicines 2017, 5, 18.

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