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J. Dev. Biol. 2016, 4(3), 22; doi:10.3390/jdb4030022

Hedgehog Signalling in the Embryonic Mouse Thymus

Immunobiology Section, UCL Institute of Child Health, London WC1N 1EH, UK
These authors contributed equally to this work.
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Author to whom correspondence should be addressed.
Academic Editors: Henk Roelink and Simon J. Conway
Received: 14 June 2016 / Revised: 11 July 2016 / Accepted: 14 July 2016 / Published: 16 July 2016
(This article belongs to the Special Issue Hedgehog Signaling in Embryogenesis)
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Abstract

T cells develop in the thymus, which provides an essential environment for T cell fate specification, and for the differentiation of multipotent progenitor cells into major histocompatibility complex (MHC)-restricted, non-autoreactive T cells. Here we review the role of the Hedgehog signalling pathway in T cell development, thymic epithelial cell (TEC) development, and thymocyte–TEC cross-talk in the embryonic mouse thymus during the last week of gestation. View Full-Text
Keywords: thymus; Hedgehog; Shh; Ihh; T cell development; thymic epithelial cell (TEC); Gli3; Gli2; Gli1 thymus; Hedgehog; Shh; Ihh; T cell development; thymic epithelial cell (TEC); Gli3; Gli2; Gli1
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Barbarulo, A.; Lau, C.-I.; Mengrelis, K.; Ross, S.; Solanki, A.; Saldaña, J.I.; Crompton, T. Hedgehog Signalling in the Embryonic Mouse Thymus. J. Dev. Biol. 2016, 4, 22.

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