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J. Dev. Biol. 2014, 2(3), 174-197; doi:10.3390/jdb2030174
Review

Retinoic Acid Signaling during Early Spinal Cord Development

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Received: 9 April 2014 / Revised: 18 June 2014 / Accepted: 18 June 2014 / Published: 26 June 2014
(This article belongs to the Special Issue Retinoids in Development)
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Abstract

Retinoic acid signaling is required at several steps during the development of the spinal cord, from the specification of generic properties to the final acquisition of neuronal subtype identities, including its role in trunk neural crest development. These functions are associated with the production of retinoic acid in specific tissues and are highly dependent on context. Here, we review the defects associated with retinoic acid signaling manipulations, mostly in chick and mouse models, trying to separate the different processes where retinoic acid signaling is involved and to highlight common features, such as its ability to promote transitions along the neuronal differentiation cascade.
Keywords: retinoic acid; spinal cord; neural tube; axis elongation; neural crest; motor neuron; dorso-ventral pattern; rostro-caudal pattern; neurogenesis retinoic acid; spinal cord; neural tube; axis elongation; neural crest; motor neuron; dorso-ventral pattern; rostro-caudal pattern; neurogenesis
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Diez del Corral, R.; Morales, A.V. Retinoic Acid Signaling during Early Spinal Cord Development. J. Dev. Biol. 2014, 2, 174-197.

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J. Dev. Biol. EISSN 2221-3759 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert