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Retinoids and Cardiac Development
AbstractRetinoic acid (RA), a derivative of vitamin A, is involved in signal transduction during vertebrate organogenesis. Retinoids through binding to nuclear receptors called RA receptors (RARs) and retinoid X receptors (RXRs) regulate various processes during cardiogenesis. Deregulated retinoid signaling thus has later consequences leading to cardiac malformations. In this review, we will summarize and discuss our current knowledge on the role of RA signaling during heart development, especially during patterning of the heart fields. We have also integrated recent experiments essential for our understanding of the role of RA signaling during epicardial development and myocardial growth.
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Zaffran, S.; Robrini, N.E.; Bertrand, N. Retinoids and Cardiac Development. J. Dev. Biol. 2014, 2, 50-71.View more citation formats
Zaffran S, Robrini NE, Bertrand N. Retinoids and Cardiac Development. Journal of Developmental Biology. 2014; 2(1):50-71.Chicago/Turabian Style
Zaffran, Stéphane; Robrini, Nicolas E.; Bertrand, Nicolas. 2014. "Retinoids and Cardiac Development." J. Dev. Biol. 2, no. 1: 50-71.