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J. Dev. Biol. 2014, 2(2), 72-83; doi:10.3390/jdb2020072
Article

Retinoic Acid, under Cerebrospinal Fluid Control, Induces Neurogenesis during Early Brain Development

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Received: 16 January 2014; in revised form: 6 March 2014 / Accepted: 18 March 2014 / Published: 8 April 2014
(This article belongs to the Special Issue Retinoids in Development)
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Abstract: One of the more intriguing subjects in neuroscience is how a precursor or stem cell is induced to differentiate into a neuron. Neurogenesis begins early in brain development and suddenly becomes a very intense process, which is related with the influence of Retinoic Acid. Here, using a biological test (F9-1.8 cells) in chick embryos, we show that “in vivo” embryonic cerebrospinal fluid regulates mesencephalic-rombencephalic Isthmic Retinoic Acid synthesis and this effect has a direct influence on mesencephalic neuroepithelial precursors, inducing a significant increase in neurogenesis. This effect is mediated by the Retinol Binding Protein present in the embryonic cerebrospinal fluid. The knowledge of embryonic neurogenetic stimulus could be useful in the control of adult brain neurogenesis.
Keywords: embryonic cerebrospinal fluid; retinoic acid; mesencephalic-rombencephalic isthmus; neuroepithelial precursors; neurogenesis embryonic cerebrospinal fluid; retinoic acid; mesencephalic-rombencephalic isthmus; neuroepithelial precursors; neurogenesis
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Alonso, M.I.; Carnicero, E.; Carretero, R.; De la Mano, A.; Moro, J.A.; Lamus, F.; Martín, C.; Gato, A. Retinoic Acid, under Cerebrospinal Fluid Control, Induces Neurogenesis during Early Brain Development. J. Dev. Biol. 2014, 2, 72-83.

AMA Style

Alonso MI, Carnicero E, Carretero R, De la Mano A, Moro JA, Lamus F, Martín C, Gato A. Retinoic Acid, under Cerebrospinal Fluid Control, Induces Neurogenesis during Early Brain Development. Journal of Developmental Biology. 2014; 2(2):72-83.

Chicago/Turabian Style

Alonso, M. I.; Carnicero, Estela; Carretero, Raquel; De la Mano, Aníbal; Moro, Jose A.; Lamus, Francisco; Martín, Cristina; Gato, Angel. 2014. "Retinoic Acid, under Cerebrospinal Fluid Control, Induces Neurogenesis during Early Brain Development." J. Dev. Biol. 2, no. 2: 72-83.

J. Dev. Biol. EISSN 2221-3759 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert