Next Article in Journal / Special Issue
Alcohol, Aldehydes, Adducts and Airways
Previous Article in Journal
The RNA Splicing Response to DNA Damage
Previous Article in Special Issue
Chronic Ethanol Exposure: Pathogenesis of Pulmonary Disease and Dysfunction
Article Menu

Export Article

Open AccessReview
Biomolecules 2015, 5(4), 2978-2986; doi:10.3390/biom5042978

Update on Alcoholic Hepatitis

1
Department of Internal Medicine, UC Davis Medical Center, Sacramento, CA 95817, USA
2
Department of Internal Medicine, Northern California VA System, Mather, CA 95655, USA
Academic Editors: Natalia Osna and Kusum Kharbanda
Received: 6 September 2015 / Revised: 26 October 2015 / Accepted: 29 October 2015 / Published: 2 November 2015
(This article belongs to the Collection Multi-Organ Alcohol-Related Damage: Mechanisms and Treatment)
View Full-Text   |   Download PDF [78 KB, uploaded 2 November 2015]

Abstract

Alcoholic liver disease is one of the most prevalent liver diseases worldwide, and a major cause of morbidity and mortality. Alcoholic hepatitis is a severe form of liver injury in patients with alcohol abuse, can present as an acute on chronic liver failure associated with a rapid decline in liver synthetic function, and consequent increase in mortality. Despite therapy, about 30%–50% of patients with severe alcoholic hepatitis eventually die. The pathogenic pathways that lead to the development of alcoholic hepatitis are complex and involve oxidative stress, gut dysbiosis, and dysregulation of the innate and adaptive immune system with injury to the parenchymal cells and activation of hepatic stellate cells. As accepted treatment approaches are currently limited, a better understanding of the pathophysiology would be required to generate new approaches that improve outcomes. This review focuses on recent advances in the diagnosis, pathogenesis of alcoholic hepatitis and novel treatment strategies. View Full-Text
Keywords: steatohepatitis; alcoholic liver injury; oxidative stress; TNFα; IL22 steatohepatitis; alcoholic liver injury; oxidative stress; TNFα; IL22
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Torok, N.J. Update on Alcoholic Hepatitis. Biomolecules 2015, 5, 2978-2986.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Biomolecules EISSN 2218-273X Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top