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Metabolites 2018, 8(2), 25; https://doi.org/10.3390/metabo8020025

Carbonic Anhydrases and Metabolism

Dipartimento Neurofarba, Sezione di Scienze Farmaceutiche, Laboratorio di Chimica Bioinorganica, Università degli Studi di Firenze, Polo Scientifico, Via U. Schiff 6, Sesto Fiorentino, 50019 Florence, Italy
Received: 18 March 2018 / Revised: 20 March 2018 / Accepted: 20 March 2018 / Published: 21 March 2018
(This article belongs to the Special Issue Carbonic Anhydrases and Metabolism)
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Abstract

Although the role of carbonic anhydrases (CAs, EC 4.2.1.1) in metabolism is well-established, pharmacological applications of this phenomenon started to be considered only recently. In organisms all over the phylogenetic tree, the seven CA genetic families known to date are involved in biosynthetic processes and pH modulation, which may influence metabolism in multiple ways, with both processes being amenable to pharmacologic intervention. CA inhibitors possess antiobesity action directly by inhibiting lipogenesis, whereas the hypoxic tumor metabolism is highly controlled by the transmembrane isoforms CA IX and XII, which contribute to the acidic extracellular environment of tumors and supply bicarbonate for their high proliferation rates. Many of the articles from this special issue deal with the role of cancer CAs in tumor metabolism and how these phenomena can be used for designing innovative antitumor therapies/imaging agents. The metabolic roles of CAs in bacteria and algae are also discussed. View Full-Text
Keywords: carbonic anhydrase; hypoxic tumor; metabolism; carboxylation; bicarbonate; pH regulation; antitumor agent; sulfonamide; bacterial enzymes carbonic anhydrase; hypoxic tumor; metabolism; carboxylation; bicarbonate; pH regulation; antitumor agent; sulfonamide; bacterial enzymes
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).
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Supuran, C.T. Carbonic Anhydrases and Metabolism. Metabolites 2018, 8, 25.

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