Identification of an Epoxide Metabolite of Lycopene in Human Plasma Using 13C-Labeling and QTOF-MS
AbstractThe carotenoid lycopene is a bioactive component of tomatoes and is hypothesized to reduce risk of several chronic diseases, such as prostate cancer. The metabolism of lycopene is only beginning to be understood and some studies suggest that metabolites of lycopene may be partially responsible for bioactivity associated with the parent compound. The detection and characterization of these compounds in vivo is an important step in understanding lycopene bioactivity. The metabolism of lycopene likely involves both chemical and enzymatic oxidation. While numerous lycopene metabolites have been proposed, few have actually been identified in vivo following lycopene intake. Here, LC-QTOF-MS was used along with 13C-labeling to investigate the post-prandial oxidative metabolism of lycopene in human plasma. Previously reported aldehyde cleavage products were not detected, but a lycopene 1,2-epoxide was identified as a new candidate oxidative metabolite. View Full-Text
Share & Cite This Article
Cichon, M.J.; Moran, N.E.; Riedl, K.M.; Schwartz, S.J.; Clinton, S.K. Identification of an Epoxide Metabolite of Lycopene in Human Plasma Using 13C-Labeling and QTOF-MS. Metabolites 2018, 8, 24.
Cichon MJ, Moran NE, Riedl KM, Schwartz SJ, Clinton SK. Identification of an Epoxide Metabolite of Lycopene in Human Plasma Using 13C-Labeling and QTOF-MS. Metabolites. 2018; 8(1):24.Chicago/Turabian Style
Cichon, Morgan J.; Moran, Nancy E.; Riedl, Ken M.; Schwartz, Steven J.; Clinton, Steven K. 2018. "Identification of an Epoxide Metabolite of Lycopene in Human Plasma Using 13C-Labeling and QTOF-MS." Metabolites 8, no. 1: 24.
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.