Next Article in Journal
GC-MS-Based Endometabolome Analysis Differentiates Prostate Cancer from Normal Prostate Cells
Next Article in Special Issue
Carbonic Anhydrases and Metabolism
Previous Article in Journal
Nanoparticle-Assisted Metabolomics
Previous Article in Special Issue
Coordinated Regulation of Metabolic Transporters and Migration/Invasion by Carbonic Anhydrase IX
Article Menu
Issue 1 (March) cover image

Export Article

Open AccessReview
Metabolites 2018, 8(1), 22; https://doi.org/10.3390/metabo8010022

An Update on the Metabolic Roles of Carbonic Anhydrases in the Model Alga Chlamydomonas reinhardtii

1
Faculty of Medicine and Life Sciences, University of Tampere, FI-33014 Tampere, Finland
2
Fimlab, Ltd., and Tampere University Hospital, FI-33520 Tampere, Finland
*
Author to whom correspondence should be addressed.
Received: 11 January 2018 / Revised: 28 February 2018 / Accepted: 10 March 2018 / Published: 13 March 2018
(This article belongs to the Special Issue Carbonic Anhydrases and Metabolism)
View Full-Text   |   Download PDF [2691 KB, uploaded 13 March 2018]   |  

Abstract

Carbonic anhydrases (CAs) are metalloenzymes that are omnipresent in nature. CAs catalyze the basic reaction of the reversible hydration of CO2 to HCO3 and H+ in all living organisms. Photosynthetic organisms contain six evolutionarily different classes of CAs, which are namely: α-CAs, β-CAs, γ-CAs, δ-CAs, ζ-CAs, and θ-CAs. Many of the photosynthetic organisms contain multiple isoforms of each CA family. The model alga Chlamydomonas reinhardtii contains 15 CAs belonging to three different CA gene families. Of these 15 CAs, three belong to the α-CA gene family; nine belong to the β-CA gene family; and three belong to the γ-CA gene family. The multiple copies of the CAs in each gene family may be due to gene duplications within the particular CA gene family. The CAs of Chlamydomonas reinhardtii are localized in different subcellular compartments of this unicellular alga. The presence of a large number of CAs and their diverse subcellular localization within a single cell suggests the importance of these enzymes in the metabolic and biochemical roles they perform in this unicellular alga. In the present review, we update the information on the molecular biology of all 15 CAs and their metabolic and biochemical roles in Chlamydomonas reinhardtii. We also present a hypothetical model showing the known functions of CAs and predicting the functions of CAs for which precise metabolic roles are yet to be discovered. View Full-Text
Keywords: carbonic anhydrases; CA gene family; Chlamydomonas reinhardtii; model alga; metabolic role; photosynthesis carbonic anhydrases; CA gene family; Chlamydomonas reinhardtii; model alga; metabolic role; photosynthesis
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Share & Cite This Article

MDPI and ACS Style

Aspatwar, A.; Haapanen, S.; Parkkila, S. An Update on the Metabolic Roles of Carbonic Anhydrases in the Model Alga Chlamydomonas reinhardtii. Metabolites 2018, 8, 22.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Metabolites EISSN 2218-1989 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top