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Cosmetics 2016, 3(2), 14; doi:10.3390/cosmetics3020014

Safety Evaluation of Cosmetic Ingredients Regarding Their Skin Sensitization Potential

Henkel AG & Co. KGaA, D-40191 Düsseldorf, Germany
Academic Editors: Emanuela Corsini and David Basketter
Received: 29 February 2016 / Revised: 21 March 2016 / Accepted: 23 March 2016 / Published: 30 March 2016
(This article belongs to the Special Issue Cosmetic Contact Allergens)
View Full-Text   |   Download PDF [1060 KB, uploaded 30 March 2016]   |  

Abstract

Up to today, product safety evaluation in the EU is predominantly based on data/information on their individual ingredients. Consequently, the quality and reliability of individual ingredient data is of vital interest. In this context, the knowledge about skin sensitization potential is an explicit need for both hazard and risk assessment. Proper skin sensitization data of the individual chemicals is essential, especially when dermal contact is intended, like for cosmetics. In some cases, e.g., in the presence of irritating chemicals, the combination of individual ingredients may also need to be evaluated to cover possible mixture effects. Today, it seems unlikely or even impossible that skin sensitization in humans can be adequately described by a single test result or even by a simple combination of a few data points (in vivo or in vitro). It is becoming evident that a set of data (including human data and market data) and knowledge about the ingredient’s specific sensitizing potency needs to be taken into account to enable a reliable assessment of skin sensitization. A more in-depth understanding on mechanistic details of the Adverse-Outcome-Pathway of skin sensitization could contribute key data for a robust conclusion on skin sensitization. View Full-Text
Keywords: AOP; Adverse-Outcome-Pathway; in vitro; IATA; post-validation; potency AOP; Adverse-Outcome-Pathway; in vitro; IATA; post-validation; potency
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Steiling, W. Safety Evaluation of Cosmetic Ingredients Regarding Their Skin Sensitization Potential. Cosmetics 2016, 3, 14.

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