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Cosmetics 2016, 3(2), 16; doi:10.3390/cosmetics3020016

Integrated Testing Strategies for Skin Sensitization Hazard and Potency Assessment—State of the Art and Challenges

Procter & Gamble, Brussels Innovation Center, 1853 Strombeek-Bever, Belgium
Academic Editors: Emanuela Corsini and David Basketter
Received: 23 March 2016 / Revised: 8 April 2016 / Accepted: 11 April 2016 / Published: 19 April 2016
(This article belongs to the Special Issue Cosmetic Contact Allergens)
View Full-Text   |   Download PDF [183 KB, uploaded 19 April 2016]

Abstract

The paper provides an overview of existing Integrated Testing Strategies (ITS) for assessing hazard and potency of skin sensitization. The ITS research is active, diverse and constantly evolving as new assays are being developed and new mechanistic insights are discovered. Despite the need to assess potency, the majority of the ITS approaches developed to date assess hazard only. Reasons for this situation are analyzed and include, for example, the dynamic range of existing alternative assays versus the range of in vivo responses, but also sporadic use of kinetic information and molar units. Depending on the application, regulatory or product development, standardized and nonstandard ITS approaches will be developed. Challenges to practical applications, with focus on regulatory are discussed. View Full-Text
Keywords: integrated testing strategy; skin sensitization; hazard and potency integrated testing strategy; skin sensitization; hazard and potency
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Jaworska, J. Integrated Testing Strategies for Skin Sensitization Hazard and Potency Assessment—State of the Art and Challenges. Cosmetics 2016, 3, 16.

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