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Biology 2015, 4(4), 715-734; doi:10.3390/biology4040715

Neutrophil Development, Migration, and Function in Teleost Fish

1
Department of Biological Sciences, University of Alberta, Edmonton, AB T6G2P5, Canada
2
Department of Agricultural, Food and Nutritional Science, University of Alberta, Edmonton, AB T6G2P5, Canada
*
Author to whom correspondence should be addressed.
Academic Editor: Brian Dixon
Received: 28 September 2015 / Revised: 30 October 2015 / Accepted: 30 October 2015 / Published: 6 November 2015
(This article belongs to the Special Issue Current Understanding of Fish Immune Systems)
View Full-Text   |   Download PDF [5191 KB, uploaded 6 November 2015]   |  

Abstract

It is now widely recognized that neutrophils are sophisticated cells that are critical to host defense and the maintenance of homeostasis. In addition, concepts such as neutrophil plasticity are helping to define the range of phenotypic profiles available to cells in this group and the physiological conditions that contribute to their differentiation. Herein, we discuss key features of the life of a teleost neutrophil including their development, migration to an inflammatory site, and contributions to pathogen killing and the control of acute inflammation. The potent anti-microbial mechanisms elicited by these cells in bony fish are a testament to their long-standing evolutionary contributions in host defense. In addition, recent insights into their active roles in the control of inflammation prior to induction of apoptosis highlight their importance to the maintenance of host integrity in these early vertebrates. Overall, our goal is to summarize recent progress in our understanding of this cell type in teleost fish, and to provide evolutionary context for the contributions of this hematopoietic lineage in host defense and an efficient return to homeostasis following injury or infection. View Full-Text
Keywords: neutrophils; teleost fish; inflammation; innate immunity; comparative immunology; inflammatory resolution neutrophils; teleost fish; inflammation; innate immunity; comparative immunology; inflammatory resolution
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Havixbeck, J.J.; Barreda, D.R. Neutrophil Development, Migration, and Function in Teleost Fish. Biology 2015, 4, 715-734.

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