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Biology 2015, 4(4), 640-663; doi:10.3390/biology4040640

T Cells in Fish

Department of Veterinary Medicine, Nihon University, Fujisawa, Kanagawa 252-0880, Japan
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Author to whom correspondence should be addressed.
Academic Editor: Brian Dixon
Received: 2 August 2015 / Revised: 11 September 2015 / Accepted: 14 September 2015 / Published: 25 September 2015
(This article belongs to the Special Issue Current Understanding of Fish Immune Systems)
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Abstract

Cartilaginous and bony fish are the most primitive vertebrates with a thymus, and possess T cells equivalent to those in mammals. There are a number of studies in fish demonstrating that the thymus is the essential organ for development of T lymphocytes from early thymocyte progenitors to functionally competent T cells. A high number of T cells in the intestine and gills has been reported in several fish species. Involvement of CD4+ and CD8α+ T cells in allograft rejection and graft-versus-host reaction (GVHR) has been demonstrated using monoclonal antibodies. Conservation of CD4+ helper T cell functions among teleost fishes has been suggested in a number studies employing mixed leukocyte culture (MLC) and hapten/carrier effect. Alloantigen- and virus-specific cytotoxicity has also been demonstrated in ginbuna and rainbow trout. Furthermore, the important role of cell-mediated immunity rather than humoral immunity has been reported in the protection against intracellular bacterial infection. Recently, the direct antibacterial activity of CD8α+, CD4+ T-cells and sIgM+ cells in fish has been reported. In this review, we summarize the recent progress in T cell research focusing on the tissue distribution and function of fish T cells. View Full-Text
Keywords: T cells; CD4; CD8; Thymus; Cytotoxicity T cells; CD4; CD8; Thymus; Cytotoxicity
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Nakanishi, T.; Shibasaki, Y.; Matsuura, Y. T Cells in Fish. Biology 2015, 4, 640-663.

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