Special Issue "Immune Mechanisms in Fish"
A special issue of Biology (ISSN 2079-7737).
Deadline for manuscript submissions: 15 May 2015
Prof. Dr. Brian Dixon
Department of Biology, University of Waterloo, ESC 350, 200 University Ave. W, Waterloo, Ontario, N2L 3G1, Canada
Fish immunity studies are at a pivotal point. Genomes of zebrafish and fugu have been examined in detail, those of rainbow trout, cod and coelacanths have recently been released, allowing for comparative studies revealing key evolutionary differences, such as lobe-finned fishes more closely resembling tetrapods or the lack of major histocompatibility class II and associated accessory genes in cod. In addition, novel technologies such as RNAseq have permitted large scale views of gene regulation. Functional studies in fish have provided novel regulatory and effector mechanisms that, upon subsequent study, are also present in mammals, such as transferrin activation of macrophages and phagocytic B cells. With this basis, future functional studies will provide even deeper insights into both mechanisms of fish immunity and the evolution of immune systems. For this special issue, we will review the state of the art in key areas of fish immunity as a basis for future studies.
Prof. Dr. Brian Dixon
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. Papers will be published continuously (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are refereed through a peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biology is an international peer-reviewed Open Access quarterly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 600 CHF (Swiss Francs). English correction and/or formatting fees of 250 CHF (Swiss Francs) will be charged in certain cases for those articles accepted for publication that require extensive additional formatting and/or English corrections.
- comparative immunology
- innate immunity
- adaptive immunity
The below list represents only planned manuscripts. Some of these manuscripts have not been received by the Editorial Office yet. Papers submitted to MDPI journals are subject to peer-review.
Type of paper: Review
Title: Phagocytosis in teleost. Implications of the new cells involved
Author: María Ángeles Esteban
Affiliation: Department of Cell Biology and Histology, Faculty of Biology, University of Murcia. 30100 Murcia, Spain; E-Mail: firstname.lastname@example.org
Abstract: Phagocytosis is the process by which certain cells engulf some solid particles to form internal vesicles known as phagosomes. Phagocytosis is in fact a specific form of endocytosis involving the vesicular interiorization of particles. In higher animals phagocytosis is essentially a defensive reaction against infection and invasion of the body by foreign substances and, in the immune system, phagocytosis is a major mechanism used to remove pathogens and/or cell debris. For these reasons, phagocytosis in vertebrates has been recognized as a critical component of the innate and adaptive immune responses to pathogens. Furthermore, more recent studies have revealed that phagocytosis is also crucial for tissue homeostasis and remodeling. Professional phagocytes in teleosts are monocyte/macrophages and granulocytes. Nevertheless, in recent years phagocytic properties have also been attribute to teleost lymphocytes and thrombocytes. The possible implications of such cells on this important biological process will be considered and discussed.
Type of Paper: Article
Title: Does MHC influence the survival of captive bred fish released in to the wild?
Authors: Sofia Consuegra *, Carlos Garcia de Leaniz
Affiliation: Swansea University, Deparment of Biosciences, E-Mails: email@example.com; firstname.lastname@example.org; Tel.: +1-111-111-111; Fax: +1-111-111-112.
Abstract: Declines in world fisheries have resulted in a rapid growth of the aquaculture industry and in the proliferation of conservation programmes based on stocking. Fish are released either intentionally, in an attempt of increasing the abundance of the populations, or inadvertently as escapees from fish farms. All of them will face selection in the natural environment that will affect their survival. Pathogens are powerful agents of selection implicated in maintaining genetic variation in host resistance, a good example being the major histocompatibility complex (MHC) of vertebrates. MHC genes are key for the immune response, and therefore should be critical for the survival of captive fish released into the wild. We analysed the relative role of MHC versus the genetic background in the survival of hatchery fish released in the wild, by following the offspring of individual families with different MHC genotypes, identified by sequencing or microsatellite genotyping.
Type of Paper: Review
Title: Nanodelivery Systems as a New Tools to Stimulate the Fish Immune System
Authors: Jie Ji, Debora Torrealba, Angels Ruyra and Nerea Roher *
Affiliation: Institute of Biotechnology and Biomedicine and Department of Cell Biology, Animal Physiology and Immunology, Universitat Autonoma de Barcelona, Barcelona, Spain;
Abstract: Fish disease treatments have progressed significantly the last years and have moved from the massive use of antibiotics to the development of vaccines mainly based on inactivated bacteria. Today, the incorporation of immunostimulants and antigens into nanomaterials give us new tools to enhance the performance of the immunostimulation. The nanoparticles are dispersions or solid particles designed with specific physical properties (size, surface charge or loading capacity) thus, allowing for controlled delivery and therefore improving the targeting and stimulation of immune system. The use of these nanodelivery platforms in fish is in the initial steps of development and here we review the advances in the application of nanoparticles to fish disease treatment including: the type of biomaterial, the type of immunostimulant loaded into the nanoparticles and how they target the fish immune system.
Last update: 2 March 2015