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Antibiotics 2016, 5(2), 14; doi:10.3390/antibiotics5020014

Structural Insights into Protein-Protein Interactions Involved in Bacterial Cell Wall Biogenesis

1
Institut de Biologie Structurale (IBS), University Grenoble Alpes, Grenoble F-38044, France
2
Centre National de la Recherche Scientifique (CNRS), IBS, Grenoble F-38044, France
3
Commissariat à l’Energie Atomique et aux Energies Alternatives (CEA), IBS, Grenoble F-38044, France
4
Brazilian National Laboratory for Biosciences (LNBio), CNPEM, Campinas, São Paulo 13083-100, Brazil
*
Author to whom correspondence should be addressed.
Academic Editor: Waldemar Vollmer
Received: 26 December 2015 / Revised: 15 March 2016 / Accepted: 9 April 2016 / Published: 28 April 2016
(This article belongs to the Special Issue Bacterial Cell Wall as Antimicrobial Target)
View Full-Text   |   Download PDF [2488 KB, uploaded 28 April 2016]   |  

Abstract

The bacterial cell wall is essential for survival, and proteins that participate in its biosynthesis have been the targets of antibiotic development efforts for decades. The biosynthesis of its main component, the peptidoglycan, involves the coordinated action of proteins that are involved in multi-member complexes which are essential for cell division (the “divisome”) and/or cell wall elongation (the “elongasome”), in the case of rod-shaped cells. Our knowledge regarding these interactions has greatly benefitted from the visualization of different aspects of the bacterial cell wall and its cytoskeleton by cryoelectron microscopy and tomography, as well as genetic and biochemical screens that have complemented information from high resolution crystal structures of protein complexes involved in divisome or elongasome formation. This review summarizes structural and functional aspects of protein complexes involved in the cytoplasmic and membrane-related steps of peptidoglycan biosynthesis, with a particular focus on protein-protein interactions whereby disruption could lead to the development of novel antibacterial strategies. View Full-Text
Keywords: peptidoglycan; elongation; cell division; protein complexes; Mur enzymes; MraY; bacterial cytoskeleton peptidoglycan; elongation; cell division; protein complexes; Mur enzymes; MraY; bacterial cytoskeleton
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Laddomada, F.; Miyachiro, M.M.; Dessen, A. Structural Insights into Protein-Protein Interactions Involved in Bacterial Cell Wall Biogenesis. Antibiotics 2016, 5, 14.

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