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A Review of Management of Clostridium difficile Infection: Primary and Recurrence
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Antibiotics 2016, 5(1), 13; doi:10.3390/antibiotics5010013

A Multi-Faceted Approach of One Teaching Hospital NHS Trust during the Clostridium difficile Epidemic—Antibiotic Management and Beyond

Department of Infection and Tropical Medicine, Leicester Royal Infirmary, Infirmary Square, Leicester LE1 5WW, UK
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Academic Editors: Yung-Fu Chang and Christopher C. Butler
Received: 26 August 2015 / Revised: 7 January 2016 / Accepted: 2 February 2016 / Published: 26 February 2016
(This article belongs to the Special Issue Clostridium difficile Infection)
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Abstract

The incidence of Clostridium difficile infection (CDI) in the UK rose dramatically during the early years of this century, in part associated with the emergence of the hyper-virulent ribotype 027 strain. The University Hospitals of Leicester (UHL), a 2000-bed acute UK NHS Trust, implemented a number of interventions, which led to an 80% reduction in new cases over a twelve month period. Changes were introduced as a result of collaboration between the Infection Prevention team, the departments of Microbiology and Infectious Diseases, and with the support of the Trust Executive. These strategies are described in detail and included; implementation of antimicrobial stewardship, specific hygiene and cleaning measures, the introduction of a care pathway form for all infected patients, the opening of an isolation ward for patients with CDI, strengthened organisation and clinical management, and rigorous attention to education within the Trust. The implementations described are of continued relevance in the face of new infection challenges, such as the increasing incidence of multi-drug resistant organisms. View Full-Text
Keywords: Clostridium difficile infection; Clostridium difficile associated disease; antimicrobial stewardship; care bundle approach Clostridium difficile infection; Clostridium difficile associated disease; antimicrobial stewardship; care bundle approach
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White, H.; Wiselka, M.; Bell, D. A Multi-Faceted Approach of One Teaching Hospital NHS Trust during the Clostridium difficile Epidemic—Antibiotic Management and Beyond. Antibiotics 2016, 5, 13.

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