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Antibiotics 2016, 5(1), 12; doi:10.3390/antibiotics5010012

Glycosyltransferases and Transpeptidases/Penicillin-Binding Proteins: Valuable Targets for New Antibacterials

Centre d’Ingénierie des Protéines, University of Liège, B6a, Quartier Agora, allée du six Août 11, 4000 Liège 1, Belgium
These authors contributed equally to this work.
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Author to whom correspondence should be addressed.
Academic Editor: Waldemar Vollmer
Received: 22 December 2015 / Revised: 27 January 2016 / Accepted: 3 February 2016 / Published: 17 February 2016
(This article belongs to the Special Issue Bacterial Cell Wall as Antimicrobial Target)
View Full-Text   |   Download PDF [2327 KB, uploaded 17 February 2016]   |  

Abstract

Peptidoglycan (PG) is an essential macromolecular sacculus surrounding most bacteria. It is assembled by the glycosyltransferase (GT) and transpeptidase (TP) activities of multimodular penicillin-binding proteins (PBPs) within multiprotein complex machineries. Both activities are essential for the synthesis of a functional stress-bearing PG shell. Although good progress has been made in terms of the functional and structural understanding of GT, finding a clinically useful antibiotic against them has been challenging until now. In contrast, the TP/PBP module has been successfully targeted by β-lactam derivatives, but the extensive use of these antibiotics has selected resistant bacterial strains that employ a wide variety of mechanisms to escape the lethal action of these antibiotics. In addition to traditional β-lactams, other classes of molecules (non-β-lactams) that inhibit PBPs are now emerging, opening new perspectives for tackling the resistance problem while taking advantage of these valuable targets, for which a wealth of structural and functional knowledge has been accumulated. The overall evidence shows that PBPs are part of multiprotein machineries whose activities are modulated by cofactors. Perturbation of these systems could lead to lethal effects. Developing screening strategies to take advantage of these mechanisms could lead to new inhibitors of PG assembly. In this paper, we present a general background on the GTs and TPs/PBPs, a survey of recent issues of bacterial resistance and a review of recent works describing new inhibitors of these enzymes. View Full-Text
Keywords: peptidoglycan; glycosyltransferase; transpeptidase; penicillin-binding proteins; β-lactam; lipid II; antibiotics resistance peptidoglycan; glycosyltransferase; transpeptidase; penicillin-binding proteins; β-lactam; lipid II; antibiotics resistance
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Sauvage, E.; Terrak, M. Glycosyltransferases and Transpeptidases/Penicillin-Binding Proteins: Valuable Targets for New Antibacterials. Antibiotics 2016, 5, 12.

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