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Antibiotics 2014, 3(4), 694-713; doi:10.3390/antibiotics3040694

Structure-Dependent Immune Modulatory Activity of Protegrin-1 Analogs

1,2,†,* , 3,4,†
and
3,4
1
Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA 30322, USA
2
Laboratories of Microbial Pathogenesis, Atlanta Department of Veterans Affairs Medical Center, Atlanta, GA 30033, USA
3
Microchemical and Proteomics Facility, Emory University School of Medicine, Atlanta, GA 30322, USA
4
Biotechnology Core Facility Branch, Division of Scientific Resources, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
These authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Received: 12 September 2014 / Revised: 31 October 2014 / Accepted: 13 November 2014 / Published: 27 November 2014
(This article belongs to the Special Issue Antimicrobial Peptides)
View Full-Text   |   Download PDF [2293 KB, uploaded 27 November 2014]   |  

Abstract

Protegrins are porcine antimicrobial peptides (AMPs) that belong to the cathelicidin family of host defense peptides. Protegrin-1 (PG-1), the most investigated member of the protegrin family, is an arginine-rich peptide consisting of 18 amino acid residues, its main chain adopting a β-hairpin structure that is linked by two disulfide bridges. We report on the immune modulatory activity of PG-1 and its analogs in neutralizing bacterial endotoxin and capsular polysaccharides, consequently inhibiting inflammatory mediators’ release from macrophages. We demonstrate that the β-hairpin structure motif stabilized with at least one disulfide bridge is a prerequisite for the immune modulatory activity of this type of AMP. View Full-Text
Keywords: protegrin-1 (PG-1); Toll-like receptor (TLR) ligands; cytokines; macrophage; innate immunity protegrin-1 (PG-1); Toll-like receptor (TLR) ligands; cytokines; macrophage; innate immunity
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Zughaier, S.M.; Svoboda, P.; Pohl, J. Structure-Dependent Immune Modulatory Activity of Protegrin-1 Analogs. Antibiotics 2014, 3, 694-713.

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